日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2' proline of the viral polyprotein

对SARS-CoV-2木瓜蛋白酶样蛋白酶选择性的研究揭示了病毒多聚蛋白P2'脯氨酸的重要性。

Chan, H T Henry; Brewitz, Lennart; Lukacik, Petra; Strain-Damerell, Claire; Walsh, Martin A; Schofield, Christopher J; Duarte, Fernanda

Cyclic β2,3-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease

环状 β2,3-氨基酸可提高针对 SARS-CoV-2 主蛋白酶的大环肽抑制剂的血清稳定性

Takashi Miura, Tika R Malla, Lennart Brewitz, Anthony Tumber, Eidarus Salah, Kang Ju Lee, Naohiro Terasaka, C David Owen, Claire Strain-Damerell, Petra Lukacik, Martin A Walsh, Akane Kawamura, Christopher J Schofield, Takayuki Katoh, Hiroaki Suga

In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease

体外筛选针对 SARS-CoV-2 主蛋白酶的含环状 γ2,4-氨基酸的大环肽抑制剂

Takashi Miura, Tika R Malla, C David Owen, Anthony Tumber, Lennart Brewitz, Michael A McDonough, Eidarus Salah, Naohiro Terasaka, Takayuki Katoh, Petra Lukacik, Claire Strain-Damerell, Halina Mikolajek, Martin A Walsh, Akane Kawamura, Christopher J Schofield, Hiroaki Suga

Accelerating drug target inhibitor discovery with a deep generative foundation model.

利用深度生成式基础模型加速药物靶点抑制剂的发现

Chenthamarakshan Vijil, Hoffman Samuel C, Owen C David, Lukacik Petra, Strain-Damerell Claire, Fearon Daren, Malla Tika R, Tumber Anthony, Schofield Christopher J, Duyvesteyn Helen M E, Dejnirattisai Wanwisa, Carrique Loic, Walter Thomas S, Screaton Gavin R, Matviiuk Tetiana, Mojsilovic Aleksandra, Crain Jason, Walsh Martin A, Stuart David I, Das Payel

Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine

SARS-CoV-2 主要蛋白酶抑制剂(包括 Nirmatrelvir)的炔烃衍生物通过与亲核半胱氨酸共价反应进行抑制

Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin A Walsh, Christopher J Schofield

xia2.multiplex: a multi-crystal data-analysis pipeline

xia2.multiplex:多晶体数据分析流程

Gildea, Richard J; Beilsten-Edmands, James; Axford, Danny; Horrell, Sam; Aller, Pierre; Sandy, James; Sanchez-Weatherby, Juan; Owen, C David; Lukacik, Petra; Strain-Damerell, Claire; Owen, Robin L; Walsh, Martin A; Winter, Graeme

Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS-CoV-2 Papain-Like Protease

质谱分析揭示了SARS-CoV-2木瓜蛋白酶样蛋白酶抑制谱的差异

Brewitz, Lennart; Kamps, Jos J A G; Lukacik, Petra; Strain-Damerell, Claire; Zhao, Yilin; Tumber, Anthony; Malla, Tika R; Orville, Allen M; Walsh, Martin A; Schofield, Christopher J

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor

不可逆衍生物设计的自动流程可识别有效的 SARS-CoV-2 Mpro 抑制剂

Daniel Zaidman, Paul Gehrtz, Mihajlo Filep, Daren Fearon, Ronen Gabizon, Alice Douangamath, Jaime Prilusky, Shirly Duberstein, Galit Cohen, C David Owen, Efrat Resnick, Claire Strain-Damerell, Petra Lukacik; Covid-Moonshot Consortium; Haim Barr, Martin A Walsh, Frank von Delft, Nir London

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19

针对新冠病毒病毒和免疫系统的双特异性再利用药物

Martin A Redhead,C David Owen,Lennart Brewitz,Amelia H Collette,Petra Lukacik,Claire Strain-Damerell,Sean W Robinson,Patrick M Collins,Philipp Schäfer,Mark Swindells,Chris J Radoux,Iva Navratilova Hopkins,Daren Fearon,Alice Douangamath,Frank von Delft,Tika R Malla,Laura Vangeel,Thomas Vercruysse,Jan Thibaut,Pieter Leyssen,Tu-Trinh Nguyen,Mitchell Hull,Anthony Tumber,David J Hallett,Christopher J Schofield,David I Stuart,Andrew L Hopkins,Martin A Walsh

The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif

非典型流感嗜血杆菌SapA在闭合构象下的结构揭示了一个狭窄的配体结合腔和一种新型的RNA结合基序。

Lukacik, Petra; Owen, C David; Harris, Gemma; Bolla, Jani Reddy; Picaud, Sarah; Alibay, Irfan; Nettleship, Joanne E; Bird, Louise E; Owens, Raymond J; Biggin, Philip C; Filippakopoulos, Panagis; Robinson, Carol V; Walsh, Martin A