日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Novel Class of Orally Bioavailable Phenylglycine-Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action

一种新型口服生物利用度高的苯甘氨酸-苯并硼氧杂环化合物,具有抗疟活性和潜在的新型作用机制

Morake, Mokhitli; Taylor, Dale; Coertzen, Dina; Njoroge, Mathew; Krugmann, Liezl; Leshabane, Meta; da Rocha, Shanté; Qahash, Tarrick; Girling, Gareth; Coyle, Rachael; Lee, Marcus C S; Wittlin, Sergio; Llinás, Manuel; Birkholtz, Lyn-Marie; Basarab, Gregory S; Chibale, Kelly

Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasites

阐明阿奇霉素类似物对疟原虫的快速杀灭机制

Mao, Emma Y; Nguyen, William; Jana, Gouranga P; Maity, Bikash C; Pazicky, Samuel; Giannangelo, Carlo; Reader, Janette; Famodimu, Mufuliat T; Birkholtz, Lyn-Marie; Delves, Michael J; Creek, Darren J; Bozdech, Zbynek; Laleu, Benoît; Burrows, Jeremy N; Sleebs, Brad E; Gancheva, Maria R; Wilson, Danny W

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining

利用预测结构和数据挖掘技术重新审视恶性疟原虫可药物靶向基因组

Godinez-Macias, Karla P; Chen, Daisy; Wallis, J Lincoln; Siegel, Miles G; Adam, Anna; Bopp, Selina; Carolino, Krypton; Coulson, Lauren B; Durst, Greg; Thathy, Vandana; Esherick, Lisl; Farringer, Madeline A; Flannery, Erika L; Forte, Barbara; Liu, Tiqing; Godoy Magalhaes, Luma; Gupta, Anil K; Istvan, Eva S; Jiang, Tiantian; Kumpornsin, Krittikorn; Lobb, Karen; McLean, Kyle J; Moura, Igor M R; Okombo, John; Payne, N Connor; Plater, Andrew; Rao, Srinivasa P S; Siqueira-Neto, Jair L; Somsen, Bente A; Summers, Robert L; Zhang, Rumin; Gilson, Michael K; Gamo, Francisco-Javier; Campo, Brice; Baragaña, Beatriz; Duffy, James; Gilbert, Ian H; Lukens, Amanda K; Dechering, Koen J; Niles, Jacquin C; McNamara, Case W; Cheng, Xiu; Birkholtz, Lyn-Marie; Bronkhorst, Alfred W; Fidock, David A; Wirth, Dyann F; Goldberg, Daniel E; Lee, Marcus C S; Winzeler, Elizabeth A

hERG, Plasmodium Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole

阿司咪唑新型氮杂苯并咪唑类似物的hERG、疟原虫生命周期和交叉耐药性分析

Mambwe, Dickson; Coertzen, Dina; Leshabane, Meta; Mulubwa, Mwila; Njoroge, Mathew; Gibhard, Liezl; Girling, Gareth; Wicht, Kathryn J; Lee, Marcus C S; Wittlin, Sergio; Moreira, Diogo Rodrigo Magalhães; Birkholtz, Lyn-Marie; Chibale, Kelly

Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer

半合成 Cryptolepine 类似物可作为治疗疟疾、非洲人类锥虫病和癌症的可持续药物的潜在来源

Yabalu Z Abacha, Arnold Donkor Forkuo, Stephen Y Gbedema, Nimisha Mittal, Sabine Ottilie, Frances Rocamora, Elizabeth A Winzeler, Donelly A van Schalkwyk, John M Kelly, Martin C Taylor, Janette Reader, Lyn-Marie Birkholtz, David R Lisgarten, Jeremy K Cockcroft, John N Lisgarten, Rex A Palmer, Rosema

The ecdysone receptor regulates several key physiological factors in Anopheles funestus

蜕皮激素受体调节不规则按蚊的几个关键生理因素

Surina Maharaj, Elodie Ekoka, Erica Erlank, Luisa Nardini, Janette Reader, Lyn-Marie Birkholtz, Lizette L Koekemoer

The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside

青蒿素-蒿甲醚-蒿甲醚-M1四联疗法:对恶性疟原虫血期寄生虫的疗效、药物代谢动力学特性及青蒿素的应用前景

Gibhard, Liezl; Coertzen, Dina; Reader, Janette; van der Watt, Mariëtte E; Birkholtz, Lyn-Marie; Wong, Ho Ning; Batty, Kevin T; Haynes, Richard K; Wiesner, Lubbe

Machine Learning Uses Chemo-Transcriptomic Profiles to Stratify Antimalarial Compounds With Similar Mode of Action

机器学习利用化学转录组学特征对作用机制相似的抗疟化合物进行分层

van Heerden, Ashleigh; van Wyk, Roelof; Birkholtz, Lyn-Marie

Structure-Activity Relationship Studies Reveal New Astemizole Analogues Active against Plasmodium falciparum In Vitro

结构-活性关系研究揭示了体外对恶性疟原虫具有活性的新型阿司咪唑类似物

Mambwe, Dickson; Kumar, Malkeet; Ferger, Richard; Taylor, Dale; Njoroge, Mathew; Coertzen, Dina; Reader, Janette; van der Watt, Mariëtte; Birkholtz, Lyn-Marie; Chibale, Kelly

MALBoost: a web-based application for gene regulatory network analysis in Plasmodium falciparum

MALBoost:一种用于恶性疟原虫基因调控网络分析的基于网络的应用程序

van Wyk, Roelof; van Biljon, Riëtte; Birkholtz, Lyn-Marie