日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting STE20-type kinase MST3 improves metabolic dysfunction-associated steatohepatitis without affecting hepatocellular carcinoma development in mice

靶向STE20型激酶MST3可改善小鼠代谢功能障碍相关的脂肪性肝炎,且不影响肝细胞癌的发生发展。

Zhang, Jingjing; Gongye, Xiangdong; Kovooru, Lohitesh; Andersson, Emma; Asiedu, Bernice; Amrutkar, Manoj; Gul, Nadia; Myers, Caitlyn; Booten, Sheri; Lind, Dan Emil; Xia, Ying; Molinaro, Antonio; Härtlova, Anetta; Lindahl, Per; Murray, Sue; Mahlapuu, Margit

Inhibition of GCKIII kinases STK25 and MST3 mitigates organ lipotoxicity and enhances metabolic resilience under nutritional stress

抑制GCKIII激酶STK25和MST3可减轻器官脂毒性,并增强营养应激下的代谢韧性。

Andersson, Emma; Gongye, Xiangdong; Cansby, Emmelie; Zhang, Jingjing; Caputo, Mara; Asiedu, Bernice; Garellick, Viktor; Booten, Sheri; Murray, Sue; Font-Gironès, Ferran; Ruud, Johan; Lind, Dan Emil; Amrutkar, Manoj; Howell, Brian W; Wernstedt Asterholm, Ingrid; Mahlapuu, Margit

Therapeutic Potential of STE20-Type Kinase STK25 Inhibition for the Prevention and Treatment of Metabolically Induced Hepatocellular Carcinoma

STE20型激酶STK25抑制剂在预防和治疗代谢性肝细胞癌中的治疗潜力

Ying Xia,Mara Caputo,Emma Andersson,Bernice Asiedu,Jingjing Zhang,Wei Hou,Manoj Amrutkar,Emmelie Cansby,Nadia Gul,Anne Gemmink,Caitlyn Myers,Mariam Aghajan,Sheri Booten,Andrew J Hoy,Anetta Härtlova,Per Lindahl,Anders Ståhlberg,Gert Schaart,Matthijs K C Hesselink,Andreas Peter,Sue Murray,Margit Mahlapuu

Therapeutic Potential of STE20-Type Kinase STK25 Inhibition for the Prevention and Treatment of Metabolically Induced Hepatocellular Carcinoma

STE20型激酶STK25抑制剂在预防和治疗代谢性肝细胞癌中的治疗潜力

Ying Xia ,Mara Caputo ,Emma Andersson ,Bernice Asiedu ,Jingjing Zhang ,Wei Hou ,Manoj Amrutkar ,Emmelie Cansby ,Nadia Gul ,Anne Gemmink ,Caitlyn Myers ,Mariam Aghajan ,Sheri Booten ,Andrew J Hoy ,Anetta Härtlova ,Per Lindahl ,Anders Ståhlberg ,Gert Schaart ,Matthijs K C Hesselink ,Andreas Peter ,Sue Murray ,Margit Mahlapuu

Genetic Ablation of STE20-Type Kinase MST4 Does Not Alleviate Diet-Induced MASLD Susceptibility in Mice

STE20 型激酶 MST4 的基因消融并不能减轻小鼠饮食引起的 MASLD 易感性

Mara Caputo, Emma Andersson, Ying Xia, Wei Hou, Emmelie Cansby, Max Erikson, Dan Emil Lind, Bengt Hallberg, Manoj Amrutkar, Margit Mahlapuu

Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in mice

STE20 型激酶 TAOK3 的敲除不会减弱小鼠饮食引起的 NAFLD 发展

Ying Xia, Emma Andersson, Mara Caputo, Emmelie Cansby, Francesca Sedda, Ferran Font-Gironès, Johan Ruud, Yeshwant Kurhe, Bengt Hallberg, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Stefano Romeo, Matthias Blüher, Margit Mahlapuu

Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways

拮抗 STK25 信号可通过靶向代谢、炎症和促癌途径抑制肝细胞癌的发展

Yeshwant Kurhe, Mara Caputo, Emmelie Cansby, Ying Xia, Sima Kumari, Sumit Kumar Anand, Brian W Howell, Hanns-Ulrich Marschall, Margit Mahlapuu

Silencing of STE20-type kinase STK25 in human aortic endothelial and smooth muscle cells is atheroprotective

抑制人主动脉内皮细胞和平滑肌细胞中的 STE20 型激酶 STK25 可预防动脉粥样硬化

Emmelie Cansby, Sima Kumari, Mara Caputo, Ying Xia, Rando Porosk, Jonathan Robinson, Hao Wang, Britt-Marie Olsson, Josefine Vallin, Julie Grantham, Ursel Soomets, L Thomas Svensson, Carina Sihlbom, Hanns-Ulrich Marschall, Andreas Edsfeldt, Isabel Goncalves, Margit Mahlapuu

Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic damage

抑制 MAP4K4 信号可启动代谢重编程,保护肝细胞免受脂毒性损伤

Sumit Kumar Anand, Mara Caputo, Ying Xia, Emma Andersson, Emmelie Cansby, Sima Kumari, Marcus Henricsson, Rando Porosk, Katharina Susanne Keuenhof, Johanna Louise Höög, Syam Nair, Hanns-Ulrich Marschall, Matthias Blüher, Margit Mahlapuu

STE20-type kinase TAOK3 regulates hepatic lipid partitioning

STE20 型激酶 TAOK3 调节肝脏脂质分配

Ying Xia, Mara Caputo, Emmelie Cansby, Sumit Kumar Anand, Silva Sütt, Marcus Henricsson, Rando Porosk, Hanns-Ulrich Marschall, Matthias Blüher, Margit Mahlapuu