日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Precision CRISPR annotation of the functional enhancer landscape in primary human T cells

利用CRISPR技术对原代人T细胞中的功能增强子图谱进行精确注释

Wang, Ping; Giles, Josephine R; Huang, Hua; Manne, Sasikanth; Jordan, Martha S; Huang, Alexander C; Shi, Junwei; Wherry, E John

Deciphering the role of histone modifications in memory and exhausted CD8 T cells.

揭示组蛋白修饰在记忆性和耗竭性 CD8 T 细胞中的作用

Huang Hua, Baxter Amy E, Zhang Zhen, Good Charly R, Alexander Katherine A, Chen Zeyu, Garcia Paula A Agudelo, Samareh Parisa, Collins Sierra M, Glastad Karl M, Wang Lu, Donahue Gregory, Manne Sasikanth, Giles Josephine R, Shi Junwei, Berger Shelley L, Wherry E John

Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8(+) T cells underlies distinct functional potential.

组织驻留记忆 CD8(+) T 细胞和组织驻留耗竭 CD8(+) T 细胞不同的个体发育过程决定了它们不同的功能潜力

Park Simone L, Painter Mark M, Manne Sasikanth, Alcalde Victor, McLaughlin Maura, Sullivan Matthew A, Mathew Divij, Torres Leonel, Huang Yinghui J, Reeg David B, Douek Naomi R, Campos Trenton, Klapholz Max, Cardenas Maria A, Fang Victoria, Ngiow Shin Foong, Kc Wumesh, Goel Rishi R, Baxter Amy E, Wu Jennifer E, Tan Melody, Berry Corbett T, Ellebrecht Christoph T, Huang Alexander C, Papazian Emily, Liu Ying, Rajasekaran Karthik, Brody Robert M, Thaler Erica R, Basu Devraj, Diab Ahmed, Giles Josephine R, Wherry E John

In vitro modeling of CD8(+) T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40

体外模拟 CD8(+) T 细胞耗竭,使得 CRISPR 筛选能够揭示 BHLHE40 的作用。

Wu, Jennifer E; Manne, Sasikanth; Ngiow, Shin Foong; Baxter, Amy E; Huang, Hua; Freilich, Elizabeth; Clark, Megan L; Lee, Joanna H; Chen, Zeyu; Khan, Omar; Staupe, Ryan P; Huang, Yinghui J; Shi, Junwei; Giles, Josephine R; Wherry, E John

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

肠道菌群通过一系列微RNA调节白色脂肪组织炎症和肥胖。

Virtue, Anthony T; McCright, Sam J; Wright, Jasmine M; Jimenez, Monica T; Mowel, Walter K; Kotzin, Jonathan J; Joannas, Leonel; Basavappa, Megha G; Spencer, Sean P; Clark, Megan L; Eisennagel, Stephen H; Williams, Adam; Levy, Maayan; Manne, Sasikanth; Henrickson, Sarah E; Wherry, E John; Thaiss, Christoph A; Elinav, Eran; Henao-Mejia, Jorge

Identification and characterization of HIV-specific resident memory CD8(+) T cells in human lymphoid tissue

人淋巴组织中HIV特异性驻留记忆CD8(+) T细胞的鉴定和表征

Buggert, Marcus; Nguyen, Son; Salgado-Montes de Oca, Gonzalo; Bengsch, Bertram; Darko, Samuel; Ransier, Amy; Roberts, Emily R; Del Alcazar, Daniel; Brody, Irene Bukh; Vella, Laura A; Beura, Lalit; Wijeyesinghe, Sathi; Herati, Ramin S; Del Rio Estrada, Perla M; Ablanedo-Terrazas, Yuria; Kuri-Cervantes, Leticia; Sada Japp, Alberto; Manne, Sasikanth; Vartanian, Shant; Huffman, Austin; Sandberg, Johan K; Gostick, Emma; Nadolski, Gregory; Silvestri, Guido; Canaday, David H; Price, David A; Petrovas, Constantinos; Su, Laura F; Vahedi, Golnaz; Dori, Yoav; Frank, Ian; Itkin, Maxim G; Wherry, E John; Deeks, Steven G; Naji, Ali; Reyes-Terán, Gustavo; Masopust, David; Douek, Daniel C; Betts, Michael R

Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection

儿童急性呼吸道感染免疫反应的基因组回路

Henrickson, Sarah E; Manne, Sasikanth; Dolfi, Douglas V; Mansfield, Kathleen D; Parkhouse, Kaela; Mistry, Rakesh D; Alpern, Elizabeth R; Hensley, Scott E; Sullivan, Kathleen E; Coffin, Susan E; Wherry, E John