日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion

一种口服、可渗透大脑的小分子通过增强伪外显子的插入来降低亨廷顿蛋白的水平

Caroline Gubser Keller #, Youngah Shin #, Alex Mas Monteys #, Nicole Renaud, Martin Beibel, Natalia Teider, Thomas Peters, Thomas Faller, Sophie St-Cyr, Judith Knehr, Guglielmo Roma, Alejandro Reyes, Marc Hild, Dmitriy Lukashev, Diethilde Theil, Natalie Dales, Jang-Ho Cha, Beth Borowsky, Ricardo Dol

DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery

DRUG-seq 为神经科学药物发现提供无偏倚的生物活性读数

Jingyao Li, Daniel J Ho, Martin Henault, Chian Yang, Marilisa Neri ,Robin Ge, Steffen Renner ,Leandra Mansur, Alicia Lindeman, Brian Kelly, Tayfun Tumkaya, Xiaoling Ke, Gilberto Soler-Llavina, Gopi Shanker, Carsten Russ, Marc Hild, Caroline Gubser Keller ,Jeremy L Jenkins, Kathleen A Worringer, Frederic D Sigoillot, Robert J Ihry

Engineering digitizer circuits for chemical and genetic screens in human cells

用于人体细胞化学和基因筛查的工程数字化仪电路

Nicole M Wong, Elizabeth Frias, Frederic D Sigoillot, Justin H Letendre, Marc Hild, Wilson W Wong

An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity

IMiD 诱导的降解决定子可对嵌合抗原受体的表达和活性进行可逆调节

Seth Carbonneau, Sujata Sharma, Liaomin Peng, Vaisakh Rajan, Dominik Hainzl, Martin Henault, Chian Yang, Jacob Hale, Janine Shulok, John Tallarico, Jeff Porter, Jennifer L Brogdon, Glenn Dranoff, James E Bradner, Marc Hild, Carla P Guimaraes

High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration

高通量功能分析区分神经退行性疾病中的致病性、非致病性和补偿性转录变化

Ismael Al-Ramahi, Boxun Lu, Simone Di Paola, Kaifang Pang, Maria de Haro, Ivana Peluso, Tatiana Gallego-Flores, Nazish T Malik, Kelly Erikson, Benjamin A Bleiberg, Matthew Avalos, George Fan, Laura Elizabeth Rivers, Andrew M Laitman, Javier R Diaz-García, Marc Hild, James Palacino, Zhandong Liu, Die

Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length

动物细胞的大小均匀性是通过 p38 MAPK 依赖的 G1 长度调节来积极维持的

Shixuan Liu #, Miriam Bracha Ginzberg #, Nish Patel, Marc Hild, Bosco Leung, Zhengda Li, Yen-Chi Chen, Nancy Chang, Yuan Wang, Ceryl Tan, Shulamit Diena, William Trimble, Larry Wasserman, Jeremy L Jenkins, Marc W Kirschner, Ran Kafri

SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice

SMN2 剪接调节剂增强 U1-pre-mRNA 结合并拯救 SMA 小鼠

James Palacino, Susanne E Swalley, Cheng Song, Atwood K Cheung, Lei Shu, Xiaolu Zhang, Mailin Van Hoosear, Youngah Shin, Donovan N Chin, Caroline Gubser Keller, Martin Beibel, Nicole A Renaud, Thomas M Smith, Michael Salcius, Xiaoying Shi, Marc Hild, Rebecca Servais, Monish Jain, Lin Deng, Caroline

Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide

DDB1-CRBN E3 泛素连接酶与沙利度胺复合物的结构

Eric S Fischer, Kerstin Böhm, John R Lydeard, Haidi Yang, Michael B Stadler, Simone Cavadini, Jane Nagel, Fabrizio Serluca, Vincent Acker, Gondichatnahalli M Lingaraju, Ritesh B Tichkule, Michael Schebesta, William C Forrester, Markus Schirle, Ulrich Hassiepen, Johannes Ottl, Marc Hild, Rohan E J Be

Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance

鉴定出 NUB1 可通过增强蛋白质清除来抑制突变型亨廷顿毒性

Boxun Lu, Ismael Al-Ramahi, Antonio Valencia, Qiong Wang, Frada Berenshteyn, Haidi Yang, Tatiana Gallego-Flores, Salah Ichcho, Arnaud Lacoste, Marc Hild, Marian Difiglia, Juan Botas, James Palacino

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Tankyrase 抑制可稳定轴蛋白并拮抗 Wnt 信号传导

Shih-Min A Huang, Yuji M Mishina, Shanming Liu, Atwood Cheung, Frank Stegmeier, Gregory A Michaud, Olga Charlat, Elizabeth Wiellette, Yue Zhang, Stephanie Wiessner, Marc Hild, Xiaoying Shi, Christopher J Wilson, Craig Mickanin, Vic Myer, Aleem Fazal, Ronald Tomlinson, Fabrizio Serluca, Wenlin Shao,