日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread

在种子诱导的tau蛋白病模型中靶向内源性tau蛋白可抑制tau蛋白扩散。

Elliot Jang ,Kevt'her Hoxha ,Damian Mozier ,Abigail Insana ,Ethan Farber ,Lakshmi Changolkar ,Bin Zhang ,Tak-Ian Chio ,Alex Crowe ,Richard Chen ,Marc Mercken ,Edward B Lee ,Kelvin C Luk ,Kurt R Brunden ,Virginia M-Y Lee ,Hong Xu

Anti-tau intrabodies: From anti-tau immunoglobulins to the development of functional scFv intrabodies

抗 tau 抗体:从抗 tau 免疫球蛋白到功能性 scFv 抗体的开发

Dina Rodrigues Martins, Fern Sha, Wim Van der Elst, Pei-Yu Shih, Jens Devoght, Kristof Van Kolen, Marc Mercken, Bianca Van Broeck, Paul Declerck, Clara Theunis

Development and validation of a high-sensitivity assay for measuring p217+tau in plasma

开发并验证一种用于测量血浆中 p217+tau 的高灵敏度检测方法

Gallen Triana-Baltzer, Setareh Moughadam, Randy Slemmon, Kristof Van Kolen, Clara Theunis, Marc Mercken, Hartmuth C Kolb

Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease

脑脊液 p-tau217 作为阿尔茨海默病的生物标志物效果优于 p-tau181

Shorena Janelidze, Erik Stomrud, Ruben Smith, Sebastian Palmqvist, Niklas Mattsson, David C Airey, Nicholas K Proctor, Xiyun Chai, Sergey Shcherbinin, John R Sims, Gallen Triana-Baltzer, Clara Theunis, Randy Slemmon, Marc Mercken, Hartmuth Kolb, Jeffrey L Dage, Oskar Hansson1

Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer's Disease Patients

早老素-1 E280A 家族性阿尔茨海默病患者脑组织中 β-淀粉样蛋白 1-38 沉积减少,β-淀粉样蛋白 1-42 沉积增加

Felix Dinkel, Diana Trujillo-Rodriguez, Andres Villegas, Johannes Streffer, Marc Mercken, Francisco Lopera, Markus Glatzel, Diego Sepulveda-Falla

Development and Validation of a High Sensitivity Assay for Measuring p217 + tau in Cerebrospinal Fluid

开发和验证一种用于测量脑脊液中 p217 + tau 的高灵敏度检测方法

Gallen Triana-Baltzer, Kristof Van Kolen, Clara Theunis, Setareh Moughadam, Randy Slemmon, Marc Mercken, Wendy Galpern, Hong Sun, Hartmuth Kolb

Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators

APP 和 Nicastrin 之间的细胞外界面调节 Aβ 长度和对 γ-分泌酶调节剂的反应

Dieter Petit, Manuel Hitzenberger, Sam Lismont, Katarzyna Marta Zoltowska, Natalie S Ryan, Marc Mercken, François Bischoff, Martin Zacharias, Lucía Chávez-Gutiérrez

Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau

增强靶向病理性tau蛋白上含磷酸化Ser422表位的天然人源抗体的治疗潜力

Jeroen van Ameijde ,Rosa Crespo ,Roosmarijn Janson ,Jarek Juraszek ,Berdien Siregar ,Hanneke Verveen ,Imke Sprengers ,Tariq Nahar ,Jeroen J Hoozemans ,Stefan Steinbacher ,Roland Willems ,Lore Delbroek ,Marianne Borgers ,Koen Dockx ,Kristof Van Kolen ,Marc Mercken ,Gabriel Pascual ,Wouter Koudstaal ,Adrian Apetri

A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities

天然存在的人类VH5-51/VL4-1抗tau抗体识别的共同抗原基序,具有不同的功能

Adrian Apetri ,Rosa Crespo ,Jarek Juraszek ,Gabriel Pascual ,Roosmarijn Janson ,Xueyong Zhu ,Heng Zhang ,Elissa Keogh ,Trevin Holland ,Jay Wadia ,Hanneke Verveen ,Berdien Siregar ,Michael Mrosek ,Renske Taggenbrock ,Jeroenvan Ameijde ,Hanna Inganäs ,Margot van Winsen ,Martin H Koldijk ,David Zuijdgeest ,Marianne Borgers ,Koen Dockx ,Esther J M Stoop ,Wenli Yu ,Els C Brinkman-van der Linden ,Kimberley Ummenthum ,Kristof van Kolen ,Marc Mercken ,Stefan Steinbacher ,Donata de Marco ,Jeroen J Hoozemans ,Ian A Wilson ,Wouter Koudstaal ,Jaap Goudsmit

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8

抗tau抗体AT8识别磷酸化tau蛋白的表位定位和结构基础

Malia, Thomas J; Teplyakov, Alexey; Ernst, Robin; Wu, Sheng-Jiun; Lacy, Eilyn R; Liu, Xuesong; Vandermeeren, Marc; Mercken, Marc; Luo, Jinquan; Sweet, Raymond W; Gilliland, Gary L