日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Detection of developmental toxicity of the anti-COVID-19 drug molnupiravir using gastruloid-based in vitro assays

利用基于类胃胚的体外试验检测抗COVID-19药物莫努匹拉韦的发育毒性

Huntsman, Margaret Carrell; Marikawa, Yusuke

Embryotoxicity analysis of anti-arrhythmia drugs amiodarone, dronedarone, and their metabolites using 3D gastruloid models

利用三维类原肠胚模型分析抗心律失常药物胺碘酮、决奈达隆及其代谢物的胚胎毒性

Kurashima, Courtney Kehaulani; Marikawa, Yusuke

Regulation of trophectoderm morphogenesis by small GTPase RHOA through HIPPO signaling-dependent and -independent mechanisms in mouse preimplantation development.

在小鼠胚胎植入前发育过程中,小 GTP 酶 RHOA 通过 HIPPO 信号依赖性和非依赖性机制调控滋养外胚层形态发生

Marikawa Yusuke, Alarcon Vernadeth B

Validation of a mouse 3D gastruloid-based embryotoxicity assay in reference to the ICH S5(R3) guideline chemical exposure list.

参照 ICH S5(R3) 指南化学品暴露清单,验证基于小鼠 3D 原肠胚的胚胎毒性试验

Huntsman Margaret Carrell, Kurashima Courtney Kehaulani, Marikawa Yusuke

An active metabolite of the anti-COVID-19 drug molnupiravir impairs mouse preimplantation embryos at clinically relevant concentrations

抗 COVID-19 药物莫努匹韦的活性代谢物在临床相关浓度下会损害小鼠植入前胚胎

Yusuke Marikawa, Vernadeth B Alarcon

Developmental toxicity of remdesivir, an anti-COVID-19 drug, is implicated by in vitro assays using morphogenetic embryoid bodies of mouse and human pluripotent stem cells

使用小鼠和人类多能干细胞的形态发生胚状体进行的体外试验表明,抗 COVID-19 药物瑞德西韦具有发育毒性

Lauren Kirkwood-Johnson, Yusuke Marikawa

Trophectoderm formation: regulation of morphogenesis and gene expressions by RHO, ROCK, cell polarity, and HIPPO signaling

滋养外胚层形成:RHO、ROCK、细胞极性和HIPPO信号通路对形态发生和基因表达的调控

Alarcon, Vernadeth B; Marikawa, Yusuke

Remdesivir impairs mouse preimplantation embryo development at therapeutic concentrations

瑞德西韦在治疗浓度下会损害小鼠植入前胚胎的发育

Yusuke Marikawa, Vernadeth B Alarcon

Ancestral Stem Cell Reprogramming Genes Active in Hemichordate Regeneration

祖先干细胞重编程基因在半索动物再生中活跃

Humphreys, Tom; Weiser, Keith; Arimoto, Asuka; Sasaki, Akane; Uenishi, Gene; Fujimoto, Brent; Kawashima, Takeshi; Taparra, Kekoa; Molnar, Janos; Satoh, Noriyuki; Marikawa, Yusuke; Tagawa, Kuni

Gastruloids: Pluripotent stem cell models of mammalian gastrulation and embryo engineering

类原肠胚:哺乳动物原肠形成和胚胎工程的多能干细胞模型

Arias, Alfonso Martinez; Marikawa, Yusuke; Moris, Naomi