日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-Based Optimization of Pyridone α-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease

基于结构的吡啶酮α-酮酰胺类化合物作为SARS-CoV-2主蛋白酶抑制剂的优化

Akula, Ravi Kumar; El Kilani, Haifa; Metzen, Alina; Röske, Judith; Zhang, Kaixuan; Göhl, Matthias; Arisetti, Nanaji; Marsh, Graham P; Maple, Hannah J; Cooper, Mark S; Karadogan, Burhan; Jochmans, Dirk; Neyts, Johan; Rox, Katharina; Hilgenfeld, Rolf; Brönstrup, Mark

Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse.

基于 ISOX-DUAL 的结构导向降解剂设计:针对 BRD4 和 CBP/EP300 的降解剂崩溃案例

Edmonds Anthony K, Balourdas Dimitrios-Ilias, Marsh Graham P, Felix Robert, Brasher Bradley, Cooper Jeff, Graber-Feesl Cari, Kollareddy Madhu, Malik Karim, Stewart Helen, Chevassut Timothy J T, Lineham Ella, Morley Simon, Fedorov Oleg, Bennett James, Rajasekaran Mohan B, Ojeda Samuel, Harrison Drew A, Ott Christopher J, Joerger Andreas C, Maple Hannah J, Spencer John

Development of p300-targeting degraders with enhanced selectivity and onset of degradation.

开发具有增强选择性和更快降解速度的p300靶向降解剂

Marsh Graham P, Cooper Mark S, Goggins Sean, Reynolds Stephen J, Wheeler Dean F, Cresser-Brown Joel O, Arnold Robert E, Babcock Emily G, Hughes Gareth, Bosnakovski Darko, Kyba Michael, Ojeda Samuel, Harrison Drew A, Ott Christopher J, Maple Hannah J

Chirality: a key parameter in chemical probes

手性:化学探针的关键参数

McGown, Andrew; Nafie, Jordan; Otayfah, Mohammed; Hassell-Hart, Storm; Tizzard, Graham J; Coles, Simon J; Banks, Rebecca; Marsh, Graham P; Maple, Hannah J; Kostakis, George E; Proietti Silvestri, Ilaria; Colbon, Paul; Spencer, John

Endothelial Glycocalyx Layer Properties and Its Ability to Limit Leukocyte Adhesion

内皮糖萼层特性及其限制白细胞黏附的能力

Delgadillo, Luis F; Marsh, Graham A; Waugh, Richard E

Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis

尿调蛋白p.Cys147Trp突变通过激活内质网应激和细胞凋亡驱动肾脏疾病

Johnson, Bryce G; Dang, Lan T; Marsh, Graham; Roach, Allie M; Levine, Zebulon G; Monti, Anthony; Reyon, Deepak; Feigenbaum, Lionel; Duffield, Jeremy S

Halloysite Nanotube Coatings Suppress Leukocyte Spreading.

埃洛石纳米管涂层抑制白细胞扩散

Hughes Andrew D, Marsh Graham, Waugh Richard E, Foster David G, King Michael R

Cell surface topography is a regulator of molecular interactions during chemokine-induced neutrophil spreading.

细胞表面形貌是趋化因子诱导的中性粒细胞扩散过程中分子相互作用的调节因子

Lomakina Elena B, Marsh Graham, Waugh Richard E