日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Prominent astrocytic GLAST pathology occurs in newborn human and piglet hypoxic-ischemic encephalopathy: modeling relationships among laminar neuropathology, seizures, and therapeutic hypothermia

新生儿和仔猪缺氧缺血性脑病中存在显著的星形胶质细胞GLAST病理:层状神经病理、癫痫发作和治疗性低温之间的关系建模

Park, Dongseok; O'Brien, Caitlin E; Lee, Jennifer K; Martin, Lee J

Hypothermia Shifts Neurodegeneration Phenotype in Neonatal Human Hypoxic-Ischemic Encephalopathy but Not in Related Piglet Models: Possible Relationship to Toxic Conformer and Intrinsically Disordered Prion-like Protein Accumulation.

低温可改变新生儿人类缺氧缺血性脑病的神经退行性表型,但对相关仔猪模型无影响:可能与毒性构象体和内在无序朊病毒样蛋白的积累有关

Martin Lee J, Lee Jennifer K, Niedzwiecki Mark V, Amrein Almira Adriana, Javdan Cameron, Chen May W, Olberding Valerie, Brown Stephen M, Park Dongseok, Yohannan Sophie, Putcha Hasitha, Zheng Becky, Garrido Annalise, Benderoth Jordan, Kisner Chloe, Ghaemmaghami Javid, Northington Frances J, Kratimenos Panagiotis

Human Mutant Dynactin Subunit 1 Causes Profound Motor Neuron Disease Consistent with Possible Mechanisms Involving Axonopathy, Mitochondriopathy, Protein Nitration, and T-Cell-Mediated Cytolysis

人类突变型动力蛋白亚基1导致严重的运动神经元疾病,其可能机制包括轴突病变、线粒体病变、蛋白质硝化和T细胞介导的细胞溶解。

Xie, Victor; Franco, Maria Clara; Martin, Lee J

Human Apolipoprotein E ε4 Allele Modulates Energy Substrate Availability, Seizure Burden, Mortality and Hippocampal Injury, Cell Death, and Inflammation after Neonatal Hypoxic-Ischemic Brain Injury

人类载脂蛋白E ε4等位基因调节新生儿缺氧缺血性脑损伤后的能量底物可用性、癫痫发作负担、死亡率、海马损伤、细胞死亡和炎症

Nazareth, Michelle; Duck, Sarah Ann; Fassinger, Abigail; Elmore, Genesis; Pinto, Charles; Nugent, Michael; St Pierre, Mark; Lechner, Charles; Jantzie, Lauren L; Northington, Frances J; Vannucci, Susan J; Martin, Lee J; Chavez-Valdez, Raul

In vivo mapping of cellular resolution neuropathology in brain ischemia with diffusion MRI

利用扩散磁共振成像技术对脑缺血中的细胞分辨率神经病理进行体内成像

Wu, Dan; Lee, Hong-Hsi; Ba, Ruicheng; Turnbill, Victoria; Wang, Xiaoli; Luo, Yu; Walczak, Piotr; Fieremans, Els; Novikov, Dmitry S; Martin, Lee J; Northington, Frances J; Zhang, Jiangyang

Neocortical cholinergic pathology after neonatal brain injury is increased by Alzheimer's disease-related genes in mice

小鼠新生儿脑损伤后新皮质胆碱能病理改变会因阿尔茨海默病相关基因的表达而加剧。

Doucette, Leslie; Turnbill, Victoria; Carlin, Katherine; Cavanagh, Andrew; Sollinger, Benjamin; Kuter, Nazli; Flock, Debra L; Robinson, Shenandoah; Chavez-Valdez, Raul; Jantzie, Lauren; Martin, Lee J; Northington, Frances J

Hypothermic Protection in Neocortex Is Topographic and Laminar, Seizure Unmitigating, and Partially Rescues Neurons Depleted of RNA Splicing Protein Rbfox3/NeuN in Neonatal Hypoxic-Ischemic Male Piglets

新皮层低温保护具有地形性和层状性,不会减轻癫痫发作,但能部分挽救新生缺氧缺血雄性仔猪中RNA剪接蛋白Rbfox3/NeuN耗竭的神经元。

Primiani, Christopher T; Lee, Jennifer K; O'Brien, Caitlin E; Chen, May W; Perin, Jamie; Kulikowicz, Ewa; Santos, Polan; Adams, Shawn; Lester, Bailey; Rivera-Diaz, Natalia; Olberding, Valerie; Niedzwiecki, Mark V; Ritzl, Eva K; Habela, Christa W; Liu, Xiuyun; Yang, Zeng-Jin; Koehler, Raymond C; Martin, Lee J

In vivo Mapping of Cellular Resolution Neuropathology in Brain Ischemia by Diffusion MRI

利用扩散磁共振成像技术对脑缺血中的细胞分辨率神经病理进行体内成像

Wu, Dan; Turnbill, Victoria; Lee, Hong-Hsi; Wang, Xiaoli; Ba, Ruicheng; Walczak, Piotr; Martin, Lee J; Fieremans, Els; Novikov, Dmitry S; Northington, Frances J; Zhang, Jiangyang

Basal forebrain magnocellular cholinergic systems are damaged in mice following neonatal hypoxia-ischemia.

新生儿缺氧缺血后,小鼠基底前脑大细胞胆碱能系统受损

Northington Frances J, Kratimenos Panagiotis, Turnbill Victoria, Flock Debra L, Asafu-Adjaye Daniella, Chavez-Valdez Raul, Martin Lee J

Mending the broken in amyotrophic lateral sclerosis: DNA damage and repair in motor neuron degeneration

修复肌萎缩侧索硬化症中的损伤:运动神经元退行性变中的DNA损伤与修复

Kim, Byung Woo; Martin, Lee J