日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Liver-directed AAV gene therapy normalizes disease symptoms and provides cross-correction in a model of lysosomal acid lipase deficiency.

肝脏靶向 AAV 基因疗法可使疾病症状正常化，并在溶酶体酸性脂肪酶缺乏症模型中提供交叉纠正

期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2024.10.022
Lam Patricia, Zygmunt Deborah A, Ashbrook Anna, Yan Cong, Du Hong, Martin Paul T
免疫/内分泌
发表日期：2024
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Dual FKRP/FST gene therapy normalizes ambulation, increases strength, decreases pathology, and amplifies gene expression in LGMDR9 mice.

双重 FKRP/FST 基因疗法可使 LGMDR9 小鼠恢复正常行走能力，增强力量，减少病理变化，并增强基因表达

期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2024.06.028
Lam Patricia, Zygmunt Deborah A, Ashbrook Anna, Bennett Macey, Vetter Tatyana A, Martin Paul T
其它
发表日期：2024
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A genome-wide association analysis of loss of ambulation in dystrophinopathy patients suggests multiple candidate modifiers of disease severity

一项针对肌营养不良症患者行走能力丧失的全基因组关联分析表明，存在多个可能影响疾病严重程度的候选修饰因子。

期刊:European Journal of Human Genetics
影响因子:4.6
doi:10.1038/s41431-023-01329-5
Flanigan, Kevin M; Waldrop, Megan A; Martin, Paul T; Alles, Roxane; Dunn, Diane M; Alfano, Lindsay N; Simmons, Tabatha R; Moore-Clingenpeel, Melissa; Burian, John; Seok, Sang-Cheol; Weiss, Robert B; Vieland, Veronica J
发表日期：2023
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rAAVrh74.MCK.GALGT2 Protects against Loss of Hemodynamic Function in the Aging mdx Mouse Heart.

rAAVrh74.MCK.GALGT2 可保护衰老的 mdx 小鼠心脏免受血流动力学功能丧失的影响

期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2019.01.005
Xu Rui, Jia Ying, Zygmunt Deborah A, Martin Paul T
心血管
Mouse
发表日期：2019
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rAAVrh74.MCK.GALGT2 Demonstrates Safety and Widespread Muscle Glycosylation after Intravenous Delivery in C57BL/6J Mice

rAAVrh74.MCK.GALGT2 在 C57BL/6J 小鼠静脉注射后显示出安全性和广泛的肌肉糖基化作用

期刊:Molecular Therapy-Methods & Clinical Development
影响因子:4.7
doi:10.1016/j.omtm.2019.10.005
Zygmunt, Deborah A; Xu, Rui; Jia, Ying; Ashbrook, Anna; Menke, Chelsea; Shao, Guohong; Yoon, Jung Hae; Hamilton, Sonia; Pisharath, Harshan; Bolon, Brad; Martin, Paul T
发表日期：2019
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Expansion of B4GALT7 linkeropathy phenotype to include perinatal lethal skeletal dysplasia

B4GALT7 连接子病表型扩展至包括围产期致死性骨骼发育不良

期刊:European Journal of Human Genetics
影响因子:4.6
doi:10.1038/s41431-019-0464-8
Mihalic Mosher, Theresa; Zygmunt, Deborah A; Koboldt, Daniel C; Kelly, Benjamin J; Johnson, Lisa R; McKenna, David S; Hood, Benjamin C; Hickey, Scott E; White, Peter; Wilson, Richard K; Martin, Paul T; McBride, Kim L
发育与干细胞
GALT
发表日期：2019
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An Isolated Limb Infusion Method Allows for Broad Distribution of rAAVrh74.MCK.GALGT2 to Leg Skeletal Muscles in the Rhesus Macaque

一种离体肢体输注方法可使 rAAVrh74.MCK.GALGT2 广泛分布于恒河猴腿部骨骼肌中。

期刊:Molecular Therapy-Methods & Clinical Development
影响因子:4.7
doi:10.1016/j.omtm.2018.06.002
Xu, Rui; Jia, Ying; Zygmunt, Deborah A; Cramer, Megan L; Crowe, Kelly E; Shao, Guohong; Maki, Agatha E; Guggenheim, Haley N; Hood, Benjamin C; Griffin, Danielle A; Peterson, Ellyn; Bolon, Brad; Cheatham, John P; Cheatham, Sharon L; Flanigan, Kevin M; Rodino-Klapac, Louise R; Chicoine, Louis G; Martin, Paul T
Rhesus
发表日期：2018
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Deletion of Pofut1 in Mouse Skeletal Myofibers Induces Muscle Aging-Related Phenotypes in cis and in trans.

小鼠骨骼肌纤维中 Pofut1 的缺失会顺式和反式诱导肌肉衰老相关表型

期刊:Molecular and Cellular Biology
影响因子:2.7
doi:10.1128/MCB.00426-16
Zygmunt Deborah A, Singhal Neha, Kim Mi-Lyang, Cramer Megan L, Crowe Kelly E, Xu Rui, Jia Ying, Adair Jessica, Martinez-Pena Y Valenzuela Isabel, Akaaboune Mohammed, White Peter, Janssen Paulus M, Martin Paul T
发育与干细胞
Mouse
发表日期：2017
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Complex formation between S100B protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signal-regulated kinase (ERK)-mediated phosphorylation of RSK

恶性黑色素瘤中 S100B 蛋白与 p90 核糖体 S6 激酶 (RSK) 之间的复合物形成是钙依赖性的，并抑制细胞外信号调节激酶 (ERK) 介导的 RSK 磷酸化

期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1074/jbc.M114.561613
Kira G Hartman, Michele I Vitolo, Adam D Pierce, Jennifer M Fox, Paul Shapiro, Stuart S Martin, Paul T Wilder, David J Weber
免疫
细胞生物学
黑色素瘤
其它细胞
MAPK/ERK
发表日期：2014
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N-Glycolylneuraminic acid deficiency worsens cardiac and skeletal muscle pathophysiology in α-sarcoglycan-deficient mice.

N-糖基神经氨酸缺乏会加重α-肌聚糖缺乏小鼠的心脏和骨骼肌病理生理

期刊:Glycobiology
影响因子:3.3
doi:10.1093/glycob/cwt020
Martin Paul T, Camboni Marybeth, Xu Rui, Golden Bethannie, Chandrasekharan Kumaran, Wang Chiou-Miin, Varki Ajit, Janssen Paul M L
神经科学
发表日期：2013
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