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Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications

激活心脏非神经胆碱能系统可预防糖尿病相关心血管并发症的发展

Eng Leng Saw, James T Pearson, Daryl O Schwenke, Pujika Emani Munasinghe, Hirotsugu Tsuchimochi, Shruti Rawal, Sean Coffey, Philip Davis, Richard Bunton, Isabelle Van Hout, Yuko Kai, Michael J A Williams, Yoshihiko Kakinuma #, Martin Fronius #, Rajesh Katare #

代谢

Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic ACh receptors

尼古丁通过含有代谢型 β4 亚基的烟碱乙酰胆碱受体刺激离子转运

期刊:British Journal of Pharmacology

影响因子:6.8

doi:10.1111/bph.15270

Praveen Kumar, Petra Scholze, Martin Fronius, Gabriela Krasteva-Christ, Monika I Hollenhorst

代谢

发表日期：2020

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Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands

剪切力在低 pH 值或存在非质子配体的情况下调节酸敏感离子通道的活性

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-019-43097-7

Daniel Barth, Martin Fronius

信号转导

发表日期：2019

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Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release

磷酸胆碱修饰的大分子和典型烟碱激动剂抑制 ATP 诱导的 IL-1β 释放

期刊:Journal of Immunology

影响因子:3.6

doi:10.4049/jimmunol.1400974

Andreas Hecker, Mira Küllmar, Sigrid Wilker, Katrin Richter, Anna Zakrzewicz, Srebrena Atanasova, Verena Mathes, Thomas Timm, Sabrina Lerner, Jochen Klein, Andreas Kaufmann, Stefan Bauer, Winfried Padberg, Wolfgang Kummer, Sabina Janciauskiene, Martin Fronius, Elke K H Schweda, Günter Lochnit, Veron

信号转导

发表日期：2015

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Nitric oxide inhibits highly selective sodium channels and the Na+/K+-ATPase in H441 cells

一氧化氮抑制 H441 细胞中的高选择性钠通道和 Na+/K+-ATPase

期刊:American Journal of Respiratory Cell and Molecular Biology

影响因子:5.9

doi:10.1165/2009-0335OC

Mike Althaus, Alexandra Pichl, Wolfgang G Clauss, Werner Seeger, Martin Fronius, Rory E Morty

Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration

大鼠肺泡巨噬细胞上的烟碱受体抑制 ATP 诱导的细胞质钙浓度升高

期刊:Respiratory Research

影响因子:6.6

doi:10.1186/1465-9921-11-133

Zbigniew Mikulski, Petra Hartmann, Gitte Jositsch, Zbigniew Zasłona, Katrin S Lips, Uwe Pfeil, Hjalmar Kurzen, Jürgen Lohmeyer, Wolfgang G Clauss, Veronika Grau, Martin Fronius, Wolfgang Kummer

Non-neuronal cholinergic system delays cardiac remodelling in type 1 diabetes

非神经元胆碱能系统延缓 1 型糖尿病患者的心脏重塑

Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications

激活心脏非神经胆碱能系统可预防糖尿病相关心血管并发症的发展

Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic ACh receptors

尼古丁通过含有代谢型 β4 亚基的烟碱乙酰胆碱受体刺激离子转运

Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands

剪切力在低 pH 值或存在非质子配体的情况下调节酸敏感离子通道的活性

Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release

磷酸胆碱修饰的大分子和典型烟碱激动剂抑制 ATP 诱导的 IL-1β 释放

Nitric oxide inhibits highly selective sodium channels and the Na+/K+-ATPase in H441 cells

一氧化氮抑制 H441 细胞中的高选择性钠通道和 Na+/K+-ATPase

Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration

大鼠肺泡巨噬细胞上的烟碱受体抑制 ATP 诱导的细胞质钙浓度升高