日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines

选择性 CK1α 降解剂对多种人类癌细胞系发挥抗增殖活性

Gisele Nishiguchi #, Lauren G Mascibroda #, Sarah M Young #, Elizabeth A Caine, Sherif Abdelhamed, Jeffrey J Kooijman, Darcie J Miller, Sourav Das, Kevin McGowan, Anand Mayasundari, Zhe Shi, Juan M Barajas, Ryan Hiltenbrand, Anup Aggarwal, Yunchao Chang, Vibhor Mishra, Shilpa Narina, Melvin Thomas, 

Structure-Activity Relationship of Potent, Selective, and Orally Bioavailable Molecular Glue Degraders of CK1α

CK1α高效、选择性强且口服生物利用度高的分子胶降解剂的构效关系

Nishiguchi, Gisele; Caine, Elizabeth A; McGowan, Kevin; Shi, Zhe; Aggarwal, Anup; Mayasundari, Anand; Price, Jeanine; Yang, Lei; Li, Yong; Fu, Xiang; Mascibroda, Lauren G; Das, Sourav; Daniels, Danette L; Urh, Marjeta; Klco, Jeffery M; Riching, Kristin M; Rankovic, Zoran

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

利用基因组规模的扰动测序技术绘制信息丰富的基因型-表型图谱

Joseph M Replogle ,Reuben A Saunders ,Angela N Pogson ,Jeffrey A Hussmann ,Alexander Lenail ,Alina Guna ,Lauren Mascibroda ,Eric J Wagner ,Karen Adelman ,Gila Lithwick-Yanai ,Nika Iremadze ,Florian Oberstrass ,Doron Lipson ,Jessica L Bonnar ,Marco Jost ,Thomas M Norman ,Jonathan S Weissman

INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex

INTS13 变异导致隐性发育性纤毛病,破坏整合子复合体的组装

Lauren G Mascibroda #, Mohammad Shboul #, Nathan D Elrod, Laurence Colleaux, Hanan Hamamy, Kai-Lieh Huang, Natoya Peart, Moirangthem Kiran Singh, Hane Lee, Barry Merriman, Jeanne N Jodoin, Poojitha Sitaram, Laura A Lee, Raja Fathalla, Baeth Al-Rawashdeh, Osama Ababneh, Mohammad El-Khateeb, Nathalie

Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination

整合子募集蛋白磷酸酶 2A 来阻止暂停释放并促进转录终止

Kai-Lieh Huang, David Jee, Chad B Stein, Nathan D Elrod, Telmo Henriques, Lauren G Mascibroda, David Baillat, William K Russell, Karen Adelman, Eric J Wagner

Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module

整合子亚基 4 是一种“Symplekin 样”支架,它与 INTS9/11 结合形成整合子切割模块。

Albrecht, Todd R; Shevtsov, Sergey P; Wu, Yixuan; Mascibroda, Lauren G; Peart, Natoya J; Huang, Kai-Lieh; Sawyer, Iain A; Tong, Liang; Dundr, Miroslav; Wagner, Eric J

Explorative Study on Isolation and Characterization of a Microviridae G4 Bacteriophage, EMCL318, against Multi-Drug-resistant Escherichia coli 15-318

对耐多药大肠杆菌15-318的Microviridae G4噬菌体EMCL318的分离和鉴定进行探索性研究

Ghosh, Soumya; Persad, Emma; Shiue, Ting-Yun; Lam, Cindy; Islam, Afsana; Mascibroda, Lauren G; Sherman, Michael B; Smith, Thomas; Cheeptham, Naowarat