日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Scaffolding Protein Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Regulates MAPK Inhibition Responsiveness in Pancreas Cancer via Crosstalk with AKT Signaling

支架蛋白连接增强子 Ras 1 激酶抑制因子 (CNKSR1) 通过与 AKT 信号相互作用调节胰腺癌中的 MAPK 抑制反应

Dandan Li #, Anne M Miermont #, Rushikesh Sable, Humair S Quadri, Lesley A Mathews Griner, Scott E Martin, Taivan Odzorig, Soumita De, Marc Ferrer, Astin S Powers, Stephen M Hewitt, Udo Rudloff

Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis

鉴定一种可破坏 SIX1/EYA2 复合物、EMT 和转移的小分子抑制剂

Hengbo Zhou ,Melanie A Blevins ,Jessica Y Hsu ,Deguang Kong ,Matthew D Galbraith ,Andrew Goodspeed ,Rachel Culp-Hill ,Michael U J Oliphant ,Dominique Ramirez ,Lingdi Zhang ,Jennyvette Trinidad-Pineiro ,Lesley Mathews Griner ,Rebecca King ,Elena Barnaeva ,Xin Hu ,Noel T Southall ,Marc Ferrer ,Daniel L Gustafson ,Daniel P Regan ,Angelo D'Alessandro ,James C Costello ,Samarjit Patnaik ,Juan Marugan ,Rui Zhao ,Heide L Ford

Identification of Small Molecule Enhancers of Immunotherapy for Melanoma

黑色素瘤免疫治疗小分子增强剂的鉴定

Christopher Dextras, Myagmarjav Dashnyam, Lesley A Mathews Griner, Janani Sundaresan, Bryan Chim, Zhiya Yu, Suman Vodnala, Chyi-Chia Richard Lee, Xin Hu, Noel Southall, Juan J Marugan, Ajit Jadhav, Nicholas P Restifo, Nicolas Acquavella, Marc Ferrer, Anju Singh

Target Deconvolution of a Multikinase Inhibitor with Antimetastatic Properties Identifies TAOK3 as a Key Contributor to a Cancer Stem Cell-Like Phenotype

具有抗转移特性的多激酶抑制剂的靶标反卷积确定 TAOK3 是癌症干细胞样表型的关键因素

Yansong Bian #, Yaroslav Teper #, Lesley A Mathews Griner #, Taylor J Aiken, Vivek Shukla, Rajarshi Guha, Paul Shinn, Hong-Wu Xin, Holger Pflicke, Astin S Powers, Dandan Li, Jian-Kang Jiang, Paresma Patel, Steven A Rogers, Jeffrey Aubé, Marc Ferrer, Craig J Thomas, Udo Rudloff

Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors

鉴定 Schlafen-11 为调节对电离辐射和拓扑异构酶抑制剂敏感性的 CD47 信号靶点

Sukhbir Kaur, Anthony L Schwartz, David G Jordan, David R Soto-Pantoja, Bethany Kuo, Abdel G Elkahloun, Lesley Mathews Griner, Craig J Thomas, Marc Ferrer, Anish Thomas, Sai-Wen Tang, Vinodh N Rajapakse, Yves Pommier, David D Roberts

Mutation Profiles in Glioblastoma 3D Oncospheres Modulate Drug Efficacy

胶质母细胞瘤 3D 囊蚴的突变谱可调节药物疗效

Kelli M Wilson, Lesley A Mathews-Griner, Tara Williamson, Rajarshi Guha, Lu Chen, Paul Shinn, Crystal McKnight, Sam Michael, Carleen Klumpp-Thomas, Zev A Binder, Marc Ferrer, Gary L Gallia, Craig J Thomas, Gregory J Riggins

Combination of anthracyclines and anti-CD47 therapy inhibit invasive breast cancer growth while preventing cardiac toxicity by regulation of autophagy

蒽环类药物与抗CD47疗法的联合应用可通过调节自噬抑制侵袭性乳腺癌的生长,同时预防心脏毒性。

Feliz-Mosquea, Yismeilin R; Christensen, Ashley A; Wilson, Adam S; Westwood, Brian; Varagic, Jasmina; Meléndez, Giselle C; Schwartz, Anthony L; Chen, Qing-Rong; Mathews Griner, Lesley; Guha, Rajarshi; Thomas, Craig J; Ferrer, Marc; Merino, Maria J; Cook, Katherine L; Roberts, David D; Soto-Pantoja, David R

Targeting Estrogen Receptor Signaling with Fulvestrant Enhances Immune and Chemotherapy-Mediated Cytotoxicity of Human Lung Cancer

氟维司群靶向雌激素受体信号增强人类肺癌的免疫和化疗介导的细胞毒性

Duane H Hamilton, Lesley Mathews Griner, Jonathan M Keller, Xin Hu, Noel Southall, Juan Marugan, Justin M David, Marc Ferrer, Claudia Palena

Large-scale pharmacological profiling of 3D tumor models of cancer cells

癌细胞 3D 肿瘤模型的大规模药理学分析

Lesley A Mathews Griner, Xiaohu Zhang, Rajarshi Guha, Crystal McKnight, Ian S Goldlust, Madhu Lal-Nag, Kelli Wilson, Sam Michael, Steve Titus, Paul Shinn, Craig J Thomas, Marc Ferrer

Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus

低剂量依米丁抗人巨细胞病毒的疗效和作用机制

Mukhopadhyay, Rupkatha; Roy, Sujayita; Venkatadri, Rajkumar; Su, Yu-Pin; Ye, Wenjuan; Barnaeva, Elena; Mathews Griner, Lesley; Southall, Noel; Hu, Xin; Wang, Amy Q; Xu, Xin; Dulcey, Andrés E; Marugan, Juan J; Ferrer, Marc; Arav-Boger, Ravit