日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Distinct Epithelial-Innate Immune Cell Transcriptional Circuits Underlie Airway Hyperresponsiveness in Asthma

独特的上皮-先天免疫细胞转录回路是哮喘气道高反应性的基础

Ryan C Murphy, Ying Lai, Matthew Liu, Taha Al-Shaikhly, Matthew C Altman, William A Altemeier, Charles W Frevert, Jason S Debley, Adrian M Piliponsky, Steven F Ziegler, Sina A Gharib, Teal S Hallstrand

Type 2 inflammation reduces SARS-CoV-2 replication in the airway epithelium in allergic asthma through functional alteration of ciliated epithelial cells

型炎症通过改变纤毛上皮细胞的功能减少过敏性哮喘患者气道上皮中 SARS-CoV-2 的复制

Naresh Doni Jayavelu, Matthew C Altman, Basilin Benson, Matthew J Dufort, Elizabeth R Vanderwall, Lucille M Rich, Maria P White, Patrice M Becker, Alkis Togias, Daniel J Jackson, Jason S Debley

Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data

用于分析和解释血液转录组数据的固定模块库的开发

Matthew C Altman #, Darawan Rinchai #, Nicole Baldwin, Mohammed Toufiq, Elizabeth Whalen, Mathieu Garand, Basirudeen Syed Ahamed Kabeer, Mohamed Alfaki, Scott R Presnell, Prasong Khaenam, Aaron Ayllón-Benítez, Fleur Mougin, Patricia Thébault, Laurent Chiche, Noemie Jourde-Chiche, J Theodore Phillips

Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region

哮喘相关基因变异通过增强子阻断调控区诱导IL33差异表达

Ivy Aneas #,Donna C Decker #,Chanie L Howard,Débora R Sobreira,Noboru J Sakabe,Kelly M Blaine,Michelle M Stein,Cara L Hrusch,Lindsey E Montefiori,Juan Tena,Kevin M Magnaye,Selene M Clay,James E Gern,Daniel J Jackson,Matthew C Altman,Edward T Naureckas,Douglas K Hogarth,Steven R White,Jose Luis Gomez-Skarmeta,Nathan Schoetler,Carole Ober,Anne I Sperling #,Marcelo A Nóbrega #

Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus

多组学共定位与全基因组关联研究揭示了儿童哮喘风险位点的特定遗传机制

Marcus M Soliai, Atsushi Kato, Britney A Helling, Catherine T Stanhope, James E Norton, Katherine A Naughton, Aiko I Klinger, Emma E Thompson, Selene M Clay, Soyeon Kim, Juan C Celedón, James E Gern, Daniel J Jackson, Matthew C Altman, Robert C Kern, Bruce K Tan, Robert P Schleimer, Dan L Nicolae, J

A modular framework for the development of targeted Covid-19 blood transcript profiling panels

用于开发针对性 Covid-19 血液转录分析面板的模块化框架

Darawan Rinchai, Basirudeen Syed Ahamed Kabeer, Mohammed Toufiq, Zohreh Tatari-Calderone, Sara Deola, Tobias Brummaier, Mathieu Garand, Ricardo Branco, Nicole Baldwin, Mohamed Alfaki, Matthew C Altman, Alberto Ballestrero, Matteo Bassetti, Gabriele Zoppoli, Andrea De Maria, Benjamin Tang, Davide Bed

Airway epithelium-shifted mast cell infiltration regulates asthmatic inflammation via IL-33 signaling

气道上皮转移肥大细胞浸润通过 IL-33 信号传导调节哮喘炎症

Matthew C Altman, Ying Lai, James D Nolin, Sydney Long, Chien-Chang Chen, Adrian M Piliponsky, William A Altemeier, Megan Larmore, Charles W Frevert, Michael S Mulligan, Steven F Ziegler, Jason S Debley, Michael C Peters, Teal S Hallstrand

Interferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function

哮喘患儿支气管上皮细胞对呼吸道合胞病毒的干扰素反应与肺功能呈负相关。

Matthew C Altman ,Stephen R Reeves ,Andrew R Parker ,Elizabeth Whalen ,Kira M Misura ,Kaitlyn A Barrow ,Richard G James ,Teal S Hallstrand ,Steven F Ziegler ,Jason S Debley

Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations

鲁索替尼可部分逆转信号转导和转录激活因子 1 (STAT1) 获得功能突变患者的功能性自然杀伤细胞缺陷

Alexander Vargas-Hernández, Emily M Mace, Ofer Zimmerman, Christa S Zerbe, Alexandra F Freeman, Sergio Rosenzweig, Jennifer W Leiding, Troy Torgerson, Matthew C Altman, Edith Schussler, Charlotte Cunningham-Rundles, Ivan K Chinn, Alexandre F Carisey, Imelda C Hanson, Nicholas L Rider, Steven M Holla

Absence of functional fetal regulatory T cells in humans causes in utero organ-specific autoimmunity

人类缺乏功能性胎儿调节性 T 细胞会导致宫内器官特异性自身免疫

Eric J Allenspach, Laura S Finn, Mara H Rendi, Ahmet Eken, Akhilesh K Singh, Mohamed Oukka, Sean D Taylor, Matthew C Altman, Corinne L Fligner, Hans D Ochs, David J Rawlings, Troy R Torgerson