日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Characterizing and engineering post-translational modifications with high-throughput cell-free expression

利用高通量无细胞表达技术对翻译后修饰进行表征和工程改造

Derek A Wong # ,Zachary M Shaver # ,Maria D Cabezas ,Martin Daniel-Ivad ,Katherine F Warfel ,Deepali V Prasanna ,Sarah E Sobol ,Regina Fernandez ,Fernando Tobias ,Szymon K Filip ,Sophia W Hulbert ,Peter Faull ,Robert Nicol ,Matthew P DeLisa ,Emily P Balskus ,Ashty S Karim ,Michael C Jewett

De novo design of peptide binders to conformationally diverse targets with contrastive language modeling

利用对比语言模型对构象不同的靶标进行肽结合剂的从头设计

Suhaas Bhat, Kalyan Palepu, Lauren Hong, Joey Mao, Tianzheng Ye, Rema Iyer, Lin Zhao, Tianlai Chen, Sophia Vincoff, Rio Watson, Tian Z Wang, Divya Srijay, Venkata Srikar Kavirayuni, Kseniia Kholina, Shrey Goel, Pranay Vure, Aniruddha J Deshpande, Scott H Soderling, Matthew P DeLisa, Pranam Chatterje

Immunoengineering can overcome the glycocalyx armour of cancer cells

免疫工程可以克服癌细胞的糖萼保护层。

Sangwoo Park,Marshall J Colville,Justin H Paek,Carolyn R Shurer,Arun Singh,Erica J Secor,Cooper J Sailer,Ling-Ting Huang,Joe Chin-Hun Kuo,Marc C Goudge,Jin Su,Minsoo Kim,Matthew P DeLisa,Sriram Neelamegham,Jan Lammerding,Warren R Zipfel,Claudia Fischbach,Heidi L Reesink,Matthew J Paszek

Novel human recombinant N-acetylgalactosamine-6-sulfate sulfatase produced in a glyco-engineered Escherichia coli strain

在糖工程大肠杆菌菌株中产生的新型人类重组 N-乙酰半乳糖胺-6-硫酸硫酸酯酶

Luisa N Pimentel-Vera, Alexander Rodríguez-López, Angela J Espejo-Mojica, Aura María Ramírez, Carolina Cardona, Luis H Reyes, Shunji Tomatsu, Thapakorn Jaroentomeechai, Matthew P DeLisa, Oscar F Sánchez, Carlos J Alméciga-Díaz

Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in Escherichia coli

发现一种能够使大肠杆菌中的全长 IgG 抗体进行糖基化的单亚基寡糖基转移酶

Belen Sotomayor, Thomas C Donahue, Sai Pooja Mahajan, May N Taw, Sophia W Hulbert, Erik J Bidstrup, D Natasha Owitipana, Alexandra Pang, Xu Yang, Souvik Ghosal, Christopher A Alabi, Parastoo Azadi, Jeffrey J Gray, Michael C Jewett, Lai-Xi Wang, Matthew P DeLisa

Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo

可编程蛋白质降解剂能够在体内和体外选择性敲低致病 β-catenin 亚群

Tianzheng Ye, Azmain Alamgir, Cara M Robertus, Darianna Colina, Connor Monticello, Thomas Connor Donahue, Lauren Hong, Sophia Vincoff, Shrey Goel, Peter Fekkes, Luis Miguel Camargo, Kieu Lam, James Heyes, David Putnam, Christopher A Alabi, Pranam Chatterjee, Matthew P DeLisa

Programmable Protein Stabilization with Language Model-Derived Peptide Guides

利用语言模型衍生的肽指南进行可编程蛋白质稳定

Lauren Hong, Tianzheng Ye, Tian Zi Wang, Divya Srijay, Lin Zhao, Rio Watson, Sophia Vincoff, Tianlai Chen, Kseniia Kholina, Shrey Goel, Matthew P DeLisa, Pranam Chatterjee

De Novo Design of Peptide Binders to Conformationally Diverse Targets with Contrastive Language Modeling

使用对比语言模型对构象多样的靶标进行肽结合剂的从头设计

Suhaas Bhat, Kalyan Palepu, Lauren Hong, Joey Mao, Tianzheng Ye, Rema Iyer, Lin Zhao, Tianlai Chen, Sophia Vincoff, Rio Watson, Tian Wang, Divya Srijay, Venkata Srikar Kavirayuni, Kseniia Kholina, Shrey Goel, Pranay Vure, Aniruddha J Desphande, Scott H Soderling, Matthew P DeLisa, Pranam Chatterjee

Isolation of full-length IgG antibodies from combinatorial libraries expressed in the cytoplasm of Escherichia coli

从大肠杆菌细胞质中表达的组合文库中分离全长 IgG 抗体

Michael-Paul Robinson #, Jinjoo Jung #, Natalia Lopez-Barbosa, Matthew Chang, Mingji Li, Thapakorn Jaroentomeechai, Emily C Cox, Xiaolu Zheng, Mehmet Berkmen, Matthew P DeLisa

A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens

通过使用生物素化抗原修饰细菌外膜囊泡实现的模块化疫苗平台

Kevin B Weyant, Ayomide Oloyede, Sukumar Pal, Julie Liao, Mariela Rivera-De Jesus, Thapakorn Jaroentomeechai, Tyler D Moeller, Steven Hoang-Phou, Sean F Gilmore, Riya Singh, Daniel C Pan, David Putnam, Christopher Locher, Luis M de la Maza, Matthew A Coleman, Matthew P DeLisa