日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers

全面剖析六种人类癌症中 2.8 Mb 拓扑相关域中的顺式调控元件

Christina M Caragine #, Victoria T Le #, Meer Mustafa, Bianca Jay Diaz, John A Morris, Simon Müller, Alejandro Mendez-Mancilla, Evan Geller, Noa Liscovitch-Brauer, Neville E Sanjana

Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase

球状体培养中的全基因组 CRISPR 筛选表明,肿瘤抑制因子 LKB1 通过 PIKFYVE 脂质激酶抑制生长

John R Ferrarone, Jerin Thomas, Arun M Unni, Yuxiang Zheng, Michal J Nagiec, Eric E Gardner, Oksana Mashadova, Kate Li, Nikos Koundouros, Antonino Montalbano, Meer Mustafa, Lewis C Cantley, John Blenis, Neville E Sanjana, Harold Varmus

LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase

LKB1 通过 PIKFYVE 脂质激酶抑制生长并促进 EGFR 的内化

John R Ferrarone, Jerin Thomas, Arun M Unni, Yuxiang Zheng, Michal J Nagiec, Eric E Gardner, Oksana Mashadova, Kate Li, Nikos Koundouros, Antonino Montalbano, Meer Mustafa, Lewis C Cantley, John Blenis, Neville E Sanjana, Harold Varmus