日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Vaccination with mRNA-encoded membrane-bound HIV Envelope trimer induces neutralizing antibodies in animal models.

用 mRNA 编码的膜结合 HIV 包膜三聚体进行疫苗接种,可在动物模型中诱导中和抗体

Ramezani-Rad Parham, Cottrell Christopher A, Marina-Zárate Ester, Liguori Alessia, Landais Elise, Torres Jonathan L, Myers Amber, Lee Jeong Hyun, Baboo Sabyasachi, Flynn Claudia, McKenney Katherine, Salcedo Eugenia, Zhou Xiaoya, Kalyuzhniy Oleksandr, Georgeson Erik, Phelps Nicole, Lu Danny, Eskandarzadeh Saman, Menis Sergey, Kubitz Michael, Groschel Bettina, Alavi Nushin, Jackson Abigail M, Lee Wen-Hsin, Tran Andy S, Ben-Akiva Elana, Michaels Katarzyna Kaczmarek, Diedrich Jolene K, Enemuo Chiamaka A, Lewis Vanessa, Pradhan Arpan, Kasturi Sudhir Pai, Schiffner Torben, Steichen Jon M, Carnathan Diane G, Himansu Sunny, Yates John R 3rd, Paulson James C, Ozorowski Gabriel, Irvine Darrell J, Silvestri Guido, Sok Devin, Ward Andrew B, Crotty Shane, Schief William R

mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models

mRNA-LNP 启动增强作用在临床前人源化小鼠模型中诱导产生类似 VRC01 的广谱中和抗体的前体。

Wang, Xuesong; Cottrell, Christopher A; Hu, Xiaozhen; Ray, Rashmi; Bottermann, Maria; Villavicencio, Paula Maldonado; Yan, Yu; Xie, Zhenfei; Warner, John E; Ellis-Pugh, Jordan Renae; Kalyuzhniy, Oleksandr; Liguori, Alessia; Willis, Jordan R; Menis, Sergey; Rämisch, Sebastian; Eskandarzadeh, Saman; Kubitz, Michael; Tingle, Ryan; Phelps, Nicole; Groschel, Bettina; Himansu, Sunny; Carfi, Andrea; Kirsch, Kathrin H; Weldon, Stephanie R; Nair, Usha; Schief, William R; Batista, Facundo D

Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming

人类免疫球蛋白基因等位基因变异影响针对种系的疫苗初次免疫。

deCamp, Allan C; Corcoran, Martin M; Fulp, William J; Willis, Jordan R; Cottrell, Christopher A; Bader, Daniel L V; Kalyuzhniy, Oleksandr; Leggat, David J; Cohen, Kristen W; Hyrien, Ollivier; Menis, Sergey; Finak, Greg; Ballweber-Fleming, Lamar; Srikanth, Abhinaya; Plyler, Jason R; Rahaman, Farhad; Lombardo, Angela; Philiponis, Vincent; Whaley, Rachael E; Seese, Aaron; Brand, Joshua; Ruppel, Alexis M; Hoyland, Wesley; Mahoney, Celia R; Cagigi, Alberto; Taylor, Alison; Brown, David M; Ambrozak, David R; Sincomb, Troy; Mullen, Tina-Marie; Maenza, Janine; Kolokythas, Orpheus; Khati, Nadia; Bethony, Jeffrey; Roederer, Mario; Diemert, David; Koup, Richard A; Laufer, Dagna S; McElrath, Juliana M; McDermott, Adrian B; Karlsson Hedestam, Gunilla B; Schief, William R

Use of Transient Transfection for cGMP Manufacturing of eOD-GT8 60mer, a Self-Assembling Nanoparticle Germline-Targeting HIV-1 Vaccine Candidate

利用瞬时转染技术进行符合cGMP规范的eOD-GT8 60mer(一种自组装纳米颗粒靶向种系HIV-1候选疫苗)生产

Sharma, Vaneet K; Menis, Sergey; Brower, Evan T; Sayeed, Eddy; Ackland, Jim; Lombardo, Angela; Cottrell, Christopher A; Torres, Jonathan L; Hassell, Thomas; Ward, Andrew B; Tsvetnitsky, Vadim; Schief, William R

A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses

首个针对人类生殖系的HIV纳米颗粒疫苗诱导了广泛且具有公共靶向性的辅助性T细胞反应。

Cohen, Kristen W; De Rosa, Stephen C; Fulp, William J; deCamp, Allan C; Fiore-Gartland, Andrew; Mahoney, Celia R; Furth, Sarah; Donahue, Josh; Whaley, Rachael E; Ballweber-Fleming, Lamar; Seese, Aaron; Schwedhelm, Katharine; Geraghty, Daniel; Finak, Greg; Menis, Sergey; Leggat, David J; Rahaman, Farhad; Lombardo, Angela; Borate, Bhavesh R; Philiponis, Vincent; Maenza, Janine; Diemert, David; Kolokythas, Orpheus; Khati, Nadia; Bethony, Jeffrey; Hyrien, Ollivier; Laufer, Dagna S; Koup, Richard A; McDermott, Adrian B; Schief, William R; McElrath, M Juliana

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

表达天然幼稚人VRC01类BCR的B细胞可在多个独立的鼠模型中被募集到生发中心并发生亲和力成熟。

Huang, Deli; Abbott, Robert K; Havenar-Daughton, Colin; Skog, Patrick D; Al-Kolla, Rita; Groschel, Bettina; Blane, Tanya R; Menis, Sergey; Tran, Jenny Tuyet; Thinnes, Theresa C; Volpi, Sabrina A; Liguori, Alessia; Schiffner, Torben; Villegas, Sophia M; Kalyuzhniy, Oleksandr; Pintea, Mark; Voss, James E; Phelps, Nicole; Tingle, Ryan; Rodriguez, Alberto R; Martin, Greg; Kupryianov, Sergey; deCamp, Allan; Schief, William R; Nemazee, David; Crotty, Shane

Nanoparticle Vaccines: In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity (Adv. Sci. 8/2020)

纳米颗粒疫苗:通过基于结构的蛋白质工程和合成DNA的协同作用实现纳米颗粒的体内组装,从而增强适应性免疫(Adv. Sci. 8/2020)

Townsend, E Andrew; Bremer, Paul T; Faunce, Kaycee E; Negus, S Stevens; Jaster, Alaina M; Robinson, Hannah L; Janda, Kim D; Banks, Matthew L; Xu, Ziyang; Wise, Megan C; Chokkalingam, Neethu; Walker, Susanne; Tello‐Ruiz, Edgar; Elliott, Sarah T C; Perales‐Puchalt, Alfredo; Xiao, Peng; Zhu, Xizhou; Pumroy, Ruth A; Fisher, Paul D; Schultheis, Katherine; Schade, Eric; Menis, Sergey; Guzman, Stacy; Andersen, Hanne; Broderick, Kate E; Humeau, Laurent M; Muthumani, Kar; Moiseenkova‐Bell, Vera; Schief, William R; Weiner, David B; Kulp, Daniel W

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

先天免疫系统对聚糖的识别可将HIV纳米颗粒免疫原靶向至生发中心。

Tokatlian, Talar; Read, Benjamin J; Jones, Christopher A; Kulp, Daniel W; Menis, Sergey; Chang, Jason Y H; Steichen, Jon M; Kumari, Sudha; Allen, Joel D; Dane, Eric L; Liguori, Alessia; Sangesland, Maya; Lingwood, Daniel; Crispin, Max; Schief, William R; Irvine, Darrell J

Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation.

对 HIV-1 Env 进行糖基工程改造,可产生“超强”和“混合”聚糖,以增强中和抗体的效力、广度和饱和度

Crooks Ema T, Grimley Samantha L, Cully Michelle, Osawa Keiko, Dekkers Gillian, Saunders Kevin, Rämisch Sebastian, Menis Sergey, Schief William R, Doria-Rose Nicole, Haynes Barton, Murrell Ben, Cale Evan Mitchel, Pegu Amarendra, Mascola John R, Vidarsson Gestur, Binley James M

Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction.

部分拆除 HIV-1 包膜糖蛋白三聚体的 CD4 结合位点聚糖栅对中和抗体诱导的影响

Crooks Ema T, Osawa Keiko, Tong Tommy, Grimley Samantha L, Dai Yang D, Whalen Robert G, Kulp Daniel W, Menis Sergey, Schief William R, Binley James M