日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Epiregulon: Single-cell transcription factor activity inference to predict drug response and drivers of cell states.

Epiregulon:通过单细胞转录因子活性推断来预测药物反应和细胞状态的驱动因素

Włodarczyk Tomasz, Lun Aaron, Wu Diana, Shi Minyi, Ye Xiaofen, Menon Shreya, Toneyan Shushan, Seidel Kerstin, Wang Liang, Tan Jenille, Chen Shang-Yang, Keyes Timothy, Chlebowski Aleksander, Waddell Adrian, Zhou Wei, Wang Yangmeng, Yuan Qiuyue, Guo Yu, Chen Liang-Fu, Daniel Bence, Hafner Antonina, He Meng, Chibly Alejandro, Liang Yuxin, Duren Zhana, Metcalfe Ciara, Hafner Marc, Siebel Christian W, Corces M Ryan, Yauch Robert, Xie Shiqi, Yao Xiaosai

Clinical Context Shapes the Relationship between Genomic Alterations and Response to AR Inhibitors and Chemotherapy in Metastatic Prostate Cancer.

临床背景决定了转移性前列腺癌中基因组改变与 AR 抑制剂和化疗反应之间的关系

Shah Kalpit, Secrest Matthew H, Zhou Wei, Wang Shu, Canter Dan, Zhang Yuxiang, Jin Dexter, Sokol Ethan, Nowicka Malgorzata, Ang Houle Armande, Metcalfe Ciara, Gendreau Steven, Schröder Carsten, Wongchenko Matthew, Attard Gerhardt

Transformer-based modeling of Clonal Selection and Expression Dynamics reveals resistance mechanisms in breast cancer.

基于Transformer的克隆选择和表达动力学建模揭示了乳腺癌的耐药机制

Maulding Nathan D, Zou Jun, Zhou Wei, Metcalfe Ciara, Stuart Joshua M, Ye Xin, Hafner Marc

CDK4/6i-treated HR+/HER2- breast cancer tumors show higher ESR1 mutation prevalence and more altered genomic landscape

接受 CDK4/6 抑制剂治疗的 HR+/HER2- 乳腺癌肿瘤表现出更高的 ESR1 突变率和更显著的基因组改变。

Chaudhary, Nayan; Chibly, Alejandro M; Collier, Ann; Martinalbo, Jorge; Perez-Moreno, Pablo; Moore, Heather M; Luhn, Patricia; Metcalfe, Ciara; Hafner, Marc

heredERA Breast Cancer: a phase III, randomized, open-label study evaluating the efficacy and safety of giredestrant plus the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection in patients with previously untreated HER2-positive, estrogen receptor-positive locally advanced or metastatic breast cancer

heredERA乳腺癌:一项III期、随机、开放标签研究,旨在评估giredestrant联合固定剂量帕妥珠单抗和曲妥珠单抗皮下注射治疗既往未接受治疗的HER2阳性、雌激素受体阳性局部晚期或转移性乳腺癌患者的疗效和安全性。

Kuemmel, Sherko; Harper-Wynne, Catherine; Park, Yeon Hee; Franke, Fábio; de Laurentiis, Michelino; Schumacher-Wulf, Eva; Eiger, Daniel; Heeson, Sarah; Cardona, Andrés; Özyilkan, Özgür; Morales-Vàsquez, Flavia; Metcalfe, Ciara; Hafner, Marc; Restuccia, Eleonora; O'Shaughnessy, Joyce

Therapeutic resistance to anti-oestrogen therapy in breast cancer

乳腺癌抗雌激素治疗的耐药性

Will, Marie; Liang, Jackson; Metcalfe, Ciara; Chandarlapaty, Sarat

An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer

一项针对绝经后局部晚期或转移性雌激素受体阳性乳腺癌女性患者的GDC-0927开放标签I期研究

Chandarlapaty, Sarat; Dickler, Maura N; Perez Fidalgo, Jose Alejandro; Villanueva-Vázquez, Rafael; Giltnane, Jennifer; Gates, Mary; Chang, Ching-Wei; Cheeti, Sravanthi; Fredrickson, Jill; Wang, Xiaojing; Collier, Ann; Moore, Heather M; Metcalfe, Ciara; Lauchle, Jennifer; Humke, Eric W; Bardia, Aditya

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

干细胞微环境特异性R-spondin 3表达的破坏会导致造血功能受损

Kurtova, Antonina V; Heinlein, Melanie; Haas, Simon; Velten, Lars; Dijkgraaf, Gerrit J P; Storm, Elaine E; Kljavin, Noelyn M; Boumahdi, Soufiane; Himmels, Patricia; Herault, Aurelie; Mancini, Andrew; Koeppen, Hartmut; Dail, Monique; Yan, Qingxiang; Zhang, Jianhuan; Koch, Ute; Radtke, Freddy; Modrusan, Zora; Metcalfe, Ciara; Piskol, Robert; de Sauvage, Frederic J

Correction: The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

更正:选择性雌激素受体下调剂 GDC-0810 在多种 ER+ 乳腺癌模型中均有效。

Joseph, James D; Darimont, Beatrice; Zhou, Wei; Arrazate, Alfonso; Young, Amy; Ingalla, Ellen; Walter, Kimberly; Blake, Robert A; Nonomiya, Jim; Guan, Zhengyu; Kategaya, Lorna; Govek, Steven P; Lai, Andiliy G; Kahraman, Mehmet; Brigham, Dan; Sensintaffar, John; Lu, Nhin; Shao, Gang; Qian, Jing; Grillot, Kate; Moon, Michael; Prudente, Rene; Bischoff, Eric; Lee, Kyoung-Jin; Bonnefous, Celine; Douglas, Karensa L; Julien, Jackaline D; Nagasawa, Johnny Y; Aparicio, Anna; Kaufman, Josh; Haley, Benjamin; Giltnane, Jennifer M; Wertz, Ingrid E; Lackner, Mark R; Nannini, Michelle A; Sampath, Deepak; Schwarz, Luis; Manning, Henry Charles; Tantawy, Mohammed Noor; Arteaga, Carlos L; Heyman, Richard A; Rix, Peter J; Friedman, Lori; Smith, Nicholas D; Metcalfe, Ciara; Hager, Jeffrey H

Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization.

LRP6 胞质尾部的稳定性元件赋予 DIX 依赖性聚合时有效的信号传导

Metcalfe Ciara, Mendoza-Topaz Carolina, Mieszczanek Juliusz, Bienz Mariann