Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β 2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies
对新型 5-羟基苯并噻唑酮衍生的 β 2-肾上腺素能受体激动剂进行药理学表征,该激动剂对骨骼肌具有功能选择性的合成代谢作用,从而在临床前研究中具有更宽的心血管安全窗口
期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.1
doi:10.1124/jpet.118.255307
Magdalena Koziczak-Holbro, Dean F Rigel, Bérengère Dumotier, David A Sykes, Jeffrey Tsao, Ngoc-Hong Nguyen, Julian Bösch, Marie Jourdain, Ludivine Flotte, Yuichiro Adachi, Michael Kiffe, Moïse Azria, Robin A Fairhurst, Steven J Charlton, Brian P Richardson, Estelle Lach-Trifilieff, David J Glass, Th