日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology

利用同理心和同情心的神经生物学原理缓解神经科医生的职业倦怠

Zeidan, Fadel; Stern, Joseph D; Mobley, William C

The history of Down syndrome-associated Alzheimer's disease; past, present, and future

唐氏综合征相关阿尔茨海默病的历史:过去、现在和未来

Maure-Blesa, Lucia; Carmona-Iragui, María; Lott, Ira; Head, Elizabeth; Wisniewski, Thomas; Rafii, Michael S; Espinosa, Joaquín; Flórez, Jesús; Mobley, William C; Holland, Anthony; Strydom, André; Zaman, Shahid; Fortea, Juan

Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose.

RAB5 过度激活会破坏内体 Rab 级联反应,导致唐氏综合征中内溶酶体功能紊乱:APP 基因剂量增加是必要的

Chen Xu-Qiao, Zuo Xinxin, Becker Ann, Mobley William C

Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome.

针对 App 和 Rab5Â 的反义寡核苷酸可使内体 Rab 活性正常化,并逆转唐氏综合征 Dp16 小鼠模型中与 DS-AD 相关的退行性表型

Chen Xu-Qiao, Zuo Xinxin, Becker Ann, Mante Michael, Florio Jazmin B, Jadhav Satish G, Albay Ricardo, Johnstone Aaron, Karachentsev Dmitry, Rissman Robert, Zhao Hien, Dowdy Steven F, Mobley William C

Stereology with OPEN-Stereo: low-cost, accessible, and accurate cellular quantification

利用 OPEN-Stereo 进行立体学分析:低成本、易用且准确的细胞定量分析

Overk, Cassia; Mobley, William C

Correction: An Anti-β-Amyloid vaccine for treating cognitive deficits in a mouse model of down syndrome

更正:一种用于治疗唐氏综合征小鼠模型认知缺陷的抗β-淀粉样蛋白疫苗

Belichenko, Pavel V; Madani, Rime; Rey-Bellet, Lorianne; Pihlgren, Maria; Becker, Ann; Plassard, Adeline; Vuillermot, Stephanie; Giriens, Valérie; Nosheny, Rachel L; Kleschevnikov, Alexander M; Valletta, Janice S; Bengtsson, Sara K S; Linke, Gordon R; Maloney, Michael T; Hickman, David T; Reis, Pedro; Granet, Anne; Mlaki, Dorin; Lopez-Deber, Maria Pilar; Do, Long; Singhal, Nishant; Masliah, Eliezer; Pearn, Matthew L; Pfeifer, Andrea; Muhs, Andreas; Mobley, William C

Tau pathology differs by sex in Alzheimer's disease in Down syndrome

阿尔茨海默病和唐氏综合征患者的tau蛋白病理存在性别差异

Chen, Xu-Qiao; Zuo, Xinxin; Mobley, William C

Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration

从诱导多能干细胞模型中汲取的关于衰老和神经退行性疾病中神经元衰老的启示

de Luzy, Isabelle R; Lee, Michael K; Mobley, William C; Studer, Lorenz

γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome.

γ-分泌酶调节剂 BPN15606 降低了 Aβ42 和 Aβ40,并对抗了唐氏综合征小鼠模型中的阿尔茨海默病相关病理

Chen Xu-Qiao, Becker Ann, Albay Ricardo, Nguyen Phuong D, Karachentsev Dmitry, Roberts Amanda J, Rynearson Kevin D, Tanzi Rudolph E, Mobley William C

BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease.

BDNF 和 TRiC 启发的试剂可挽救亨廷顿病小鼠模型中的皮层突触缺陷

Gu Yingli, Pope Alexander, Smith Charlene, Carmona Christopher, Johnstone Aaron, Shi Linda, Chen Xuqiao, Santos Sarai, Bacon-Brenes Claire Cecile, Shoff Thomas, Kleczko Korbin M, Frydman Judith, Thompson Leslie M, Mobley William C, Wu Chengbiao