日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice

单次注射小分子药物可使小鼠体内大型乳腺肿瘤完全消退

Mulligan, Michael P; Boudreau, Matthew W; Bouwens, Brooke A; Lee, Yoongyeong; Carrell, Hunter W; Zhu, Junyao; Mousses, Spyro; Shapiro, David J; Nelson, Erik R; Fan, Timothy M; Hergenrother, Paul J

A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice

一种小分子未折叠蛋白反应激活剂可根除小鼠体内的人类乳腺肿瘤。

Boudreau, Matthew W; Duraki, Darjan; Wang, Lawrence; Mao, Chengjian; Kim, Ji Eun; Henn, Madeline A; Tang, Bingtao; Fanning, Sean W; Kiefer, Jeffrey; Tarasow, Theodore M; Bruckheimer, Elizabeth M; Moreno, Ramon; Mousses, Spyro; Greene, Geoffrey L; Roy, Edward J; Park, Ben Ho; Fan, Timothy M; Nelson, Erik R; Hergenrother, Paul J; Shapiro, David J

The BioIntelligence Framework: a new computational platform for biomedical knowledge computing

生物智能框架:一种用于生物医学知识计算的新型计算平台

Farley, Toni; Kiefer, Jeff; Lee, Preston; Von Hoff, Daniel; Trent, Jeffrey M; Colbourn, Charles; Mousses, Spyro

Kinome-wide siRNA screening identifies molecular targets mediating the sensitivity of pancreatic cancer cells to Aurora kinase inhibitors

全激酶组 siRNA 筛选可识别介导胰腺癌细胞对 Aurora 激酶抑制剂敏感性的分子靶点

Lifang Xie, Michelle Kassner, Ruben M Munoz, Qiang Q Que, Jeff Kiefer, Yu Zhao, Spyro Mousses, Hongwei H Yin, Daniel D Von Hoff, Haiyong Han

High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells

高通量RNAi筛选揭示TNK1在胰腺癌细胞生长和存活中的作用

Henderson, Meredith C; Gonzales, Irma M; Arora, Shilpi; Choudhary, Ashish; Trent, Jeffrey M; Von Hoff, Daniel D; Mousses, Spyro; Azorsa, David O

RNAi phenotype profiling of kinases identifies potential therapeutic targets in Ewing's sarcoma

RNAi激酶表型分析可识别尤文氏肉瘤的潜在治疗靶点

Arora, Shilpi; Gonzales, Irma M; Hagelstrom, R Tanner; Beaudry, Christian; Choudhary, Ashish; Sima, Chao; Tibes, Raoul; Mousses, Spyro; Azorsa, David O

Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6

人类多发性骨髓瘤的激酶组范围 RNAi 研究确定了易受攻击的激酶靶点,包括淋巴限制性激酶 GRK6

Rodger E Tiedemann, Yuan Xiao Zhu, Jessica Schmidt, Hongwei Yin, Chang-Xin Shi, Qiang Que, Gargi Basu, David Azorsa, Louise M Perkins, Esteban Braggio, Rafael Fonseca, P Leif Bergsagel, Spyro Mousses, A Keith Stewart

Array-based gene expression, CGH and tissue data defines a 12q24 gain in neuroblastic tumors with prognostic implication

基于阵列的基因表达、CGH 和组织数据确定了神经母细胞肿瘤中 12q24 的增益,具有预后意义

Maija Wolf, Miikka Korja, Ritva Karhu, Henrik Edgren, Sami Kilpinen, Kalle Ojala, Spyro Mousses, Anne Kallioniemi, Hannu Haapasalo

Elevated expression of the cytochrome b561, a neuroendocrine vesicle protein, in castration resistant prostate tumors

去势抵抗性前列腺肿瘤中神经内分泌囊泡蛋白细胞色素b561表达升高

Srivastava, Anjali; Mousses, Spyro; Dobi, Albert; Leighton, Ximena

Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer

合成致死 RNAi 筛选确定胰腺癌吉西他滨治疗的敏感靶点

David O Azorsa, Irma M Gonzales, Gargi D Basu, Ashish Choudhary, Shilpi Arora, Kristen M Bisanz, Jeffrey A Kiefer, Meredith C Henderson, Jeffrey M Trent, Daniel D Von Hoff, Spyro Mousses