日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Central control of dynamic gene circuits governs T cell rest and activation

动态基因回路的中央调控控制着T细胞的静息和激活。

Maya M Arce ,Jennifer M Umhoefer ,Nadia Arang ,Sivakanthan Kasinathan ,Jacob W Freimer ,Zachary Steinhart ,Haolin Shen ,Minh T N Pham ,Mineto Ota ,Anika Wadhera ,Rama Dajani ,Dmytro Dorovskyi ,Yan Yi Chen ,Qi Liu ,Yuan Zhou ,Danielle L Swaney ,Kirsten Obernier ,Brian R Shy ,Julia Carnevale ,Ansuman T Satpathy ,Nevan J Krogan ,Jonathan K Pritchard ,Alexander Marson

FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

FAK抑制剂联合RAF-MEK钳制抑制剂avutometinib可克服BRAF V600E黑色素瘤对靶向治疗和免疫疗法的耐药性。

Simone Lubrano,Rodolfo Daniel Cervantes-Villagrana,Farhoud Faraji,Sydney Ramirez,Kuniaki Sato,Sendi R Adame-Garcia,Adam Officer,Nadia Arang,Damiano C Rigiracciolo,Paola Y Anguiano Quiroz,Claudia Martini,YiYu Wang,Fleur M Ferguson,Antonietta Bacchiocchi,Ruth Halaban,Silvia Coma,Sheri L Holmen,Jonathan A Pachter,Andrew E Aplin,J Silvio Gutkind

Targeting a lineage-specific PI3Kɣ-Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule

使用异双功能降解分子靶向急性髓系白血病中的谱系特异性 PI3Kɣ-Akt 信号传导模块

Lois M Kelly #, Justine C Rutter #, Kevin H Lin #, Frank Ling, Matthieu Duchmann, Emmanuelle Latour, Nadia Arang, Hélène Pasquer, Duong Ho Nhat, Juliette Charles, Shane T Killarney, Hazel X Ang, Federica Namor, Cécile Culeux, Bérangère Lombard, Damarys Loew, Danielle L Swaney, Nevan J Krogan, Luc Br

Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation

致癌 G 蛋白和 GPCR 信号的系统建模揭示了下游通路激活的意外差异

Michael Trogdon, Kodye Abbott, Nadia Arang, Kathryn Lande, Navneet Kaur, Melinda Tong, Mathieu Bakhoum, J Silvio Gutkind, Edward C Stites1

A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

激酶组范围的合成致死 CRISPR/Cas9 筛选表明,mTOR 抑制可防止 HNSCC 对 CDK4/CDK6 阻断产生适应性抗性

Yusuke Goto #, Keiichi Koshizuka #, Toshinori Ando, Hiroki Izumi, Xingyu Wu, Kuniaki Sato, Tomohiko Ishikawa, Kyle Ford, Xiaodong Feng, Zhiyong Wang, Nadia Arang, Michael M Allevato, Ayush Kishore, Prashant Mali, J Silvio Gutkind

High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

高通量化学遗传药物筛选揭示 PKC-RhoA/PKN 是 GNAQ 驱动的葡萄膜黑色素瘤中可靶向的信号通路脆弱性

Nadia Arang ,Simone Lubrano ,Michele Ceribelli ,Damiano C Rigiracciolo ,Robert Saddawi-Konefka ,Farhoud Faraji ,Sydney I Ramirez ,Daehwan Kim ,Frances A Tosto ,Erica Stevenson ,Yuan Zhou ,Zhiyong Wang ,Julius Bogomolovas ,Alfredo A Molinolo ,Danielle L Swaney ,Nevan J Krogan ,Jing Yang ,Silvia Coma ,Jonathan A Pachter ,Andrew E Aplin ,Dario R Alessi ,Craig J Thomas ,J Silvio Gutkind

Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ-focal adhesion kinase signaling circuitry

全基因组 CRISPR 筛选确定 PI3K/AKT 是致癌 GNAQ-粘着斑激酶信号通路的下游成分

Nadia Arang, Simone Lubrano, Damiano Cosimo Rigiracciolo, Daniela Nachmanson, Scott M Lippman, Prashant Mali, Olivier Harismendy, J Silvio Gutkind

Catalytic site mutations confer multiple states of G protein activation

催化位点突变导致 G 蛋白活化的多种状态

Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, J Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman

Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC)

粘着斑激酶 (FAK)-Hippo/YAP 转导信号介导 S100A8/A9-RAGE 系统在三阴性乳腺癌 (TNBC) 中发挥的刺激作用

Damiano Cosimo Rigiracciolo, Nijiro Nohata, Rosamaria Lappano, Francesca Cirillo, Marianna Talia, Sendi Rafael Adame-Garcia, Nadia Arang, Simone Lubrano, Ernestina Marianna De Francesco, Antonino Belfiore, J Silvio Gutkind, Marcello Maggiolini

A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection

全基因组 CRISPR-Cas9 筛选确定 CENPJ 是疟原虫肝脏感染期间改变微管组织的宿主调节剂

Kamalakannan Vijayan, Nadia Arang, Ling Wei, Robert Morrison, Rechel Geiger, K Rachael Parks, Adam J Lewis, Fred D Mast, Alyse N Douglass, Heather S Kain, John D Aitchison, Jarrod S Johnson, Alan Aderem, Alexis Kaushansky