日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson's disease

葡萄糖脑苷脂酶活性和脂质水平与帕金森病的蛋白质病理有关

Cheryl E G Leyns, Alice Prigent, Brenna Beezhold, Lihang Yao, Nathan G Hatcher, Peining Tao, John Kang, EunRan Suh, Vivianna M Van Deerlin, John Q Trojanowski, Virginia M Y Lee, Matthew E Kennedy, Matthew J Fell, Michael X Henderson

Toward Omics-Scale Quantitative Mass Spectrometry Imaging of Lipids in Brain Tissue Using a Multiclass Internal Standard Mixture

使用多类内部标准混合物对脑组织中的脂质进行组学规模定量质谱成像

Michiel Vandenbosch, Shadrack M Mutuku, Maria José Q Mantas, Nathan H Patterson, Tucker Hallmark, Marc Claesen, Ron M A Heeren, Nathan G Hatcher, Nico Verbeeck, Kim Ekroos, Shane R Ellis

Neuronopathic GBA1L444P Mutation Accelerates Glucosylsphingosine Levels and Formation of Hippocampal Alpha-Synuclein Inclusions

神经病变 GBA1L444P 突变加速葡萄糖鞘氨醇水平和海马 α-突触核蛋白内含物的形成

Casey L Mahoney-Crane, Megha Viswanathan, Dreson Russell, Rachel A C Curtiss, Jennifer Freire, Sai Sumedha Bobba, Sean D Coyle, Monika Kandebo, Lihang Yao, Bang-Lin Wan, Nathan G Hatcher, Sean M Smith, Jacob N Marcus, Laura A Volpicelli-Daley

Proteomic Discovery and Validation of Novel Fluid Biomarkers for Improved Patient Selection and Prediction of Clinical Outcomes in Alzheimer's Disease Patient Cohorts

蛋白质组学发现和验证新型液体生物标志物,以改善阿尔茨海默病患者群体的患者选择和预测临床结果

Shivangi Awasthi, Daniel S Spellman, Nathan G Hatcher

A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy

一种新型葡萄糖神经酰胺合酶抑制剂可减轻突触核蛋白病临床前模型中的 α 突触核蛋白病理和溶酶体功能障碍

Mali Cosden, Sarah Jinn, Lihang Yao, Cheryl A Gretzula, Monika Kandebo, Dawn Toolan, Nathan G Hatcher, Lei Ma, Wei Lemaire, Gregory C Adam, Christine Burlein, Christina Minnick, Rose Flick, Marla L Watt, James Mulhearn, Mark Fraley, Robert E Drolet, Jacob N Marcus, Sean M Smith

Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells

内化的 Tau 寡聚体通过诱导多能干细胞来源的人类神经元中致病性 Tau 的积累引起神经退行性病变

Marija Usenovic, Shahriar Niroomand, Robert E Drolet, Lihang Yao, Renee C Gaspar, Nathan G Hatcher, Joel Schachter, John J Renger, Sophie Parmentier-Batteur

A sensitive aβ oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid

灵敏的 aβ 寡聚体检测可区分阿尔茨海默氏症患者和老年对照脑脊液

Mary J Savage, Juliya Kalinina, Abigail Wolfe, Katherine Tugusheva, Rachel Korn, Tanesha Cash-Mason, Jill W Maxwell, Nathan G Hatcher, Sharie J Haugabook, Guoxin Wu, Bonnie J Howell, John J Renger, Paul J Shughrue, Alexander McCampbell

Fibrinogen α-chain-derived peptide is upregulated in hippocampus of rats exposed to acute morphine injection and spontaneous alternation testing

急性吗啡注射和自发交替测试大鼠海马中纤维蛋白原 α 链衍生肽上调

Agatha E Maki, Kenneth A Morris, Kasia Catherman, Xian Chen, Nathan G Hatcher, Paul E Gold, Jonathan V Sweedler

Collecting peptide release from the brain using porous polymer monolith-based solid phase extraction capillaries

使用多孔聚合物整体式固相萃取毛细管收集大脑中的肽释放

Jamie M Iannacone, Shifang Ren, Nathan G Hatcher, Jonathan V Sweedler

SIMS and MALDI MS imaging of the spinal cord

脊髓的 SIMS 和 MALDI MS 成像

Eric B Monroe, Suresh P Annangudi, Nathan G Hatcher, Howard B Gutstein, Stanislav S Rubakhin, Jonathan V Sweedler