日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

HSP90 inhibition disrupts telomere maintenance and promotes chromosomal instability (CIN) in cancer cells

HSP90抑制会破坏端粒维持并促进癌细胞的染色体不稳定(CIN)。

Lee, Hee-Sheung; Kim, Jung-Hyun; Liskovykh, Mikhail; Len, Neckers; Kouprina, Natalay; Larionov, Vladimir

Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT

线粒体 HSP90 同源基因 TRAP1 缺失通过破坏 Cys/Glu 反向转运蛋白 SLC7A11/xCT 的稳定性,驱动肿瘤细胞对谷氨酰胺的依赖性

Abhinav Joshi # ,Li Dai # ,Marisa Maisiak ,Sunmin Lee ,Elizabeth Lopez ,Takeshi Ito ,Len Neckers

Mitochondrial chaperon TNF-receptor- associated protein 1 as a novel apoptotic regulator conferring susceptibility to Pneumocystis jirovecii pneumonia

线粒体伴侣 TNF 受体相关蛋白 1 是一种新型凋亡调节剂,可导致耶氏肺孢子虫肺炎的易感性

Aseervatham Anusha Amali #, Kathirvel Paramasivam #, Chiung Hui Huang, Abhinav Joshi, Jayshree L Hirpara, Sharada Ravikumar, Qi Hui Sam, Rachel Ying Min Tan, Zhaohong Tan, Dilip Kumar, Leonard M Neckers, Shazib Pervaiz, Roger Foo, Candice Y Y Chan, Jin Zhu, Cheryl Lee #, Louis Yi Ann Chai #

Second international symposium on the chaperone code, 2023

第二届国际陪护人员守则研讨会,2023年

Buchner, Johannes; Alasady, Milad J; Backe, Sarah J; Blagg, Brian S J; Carpenter, Richard L; Colombo, Giorgio; Gelis, Ioannis; Gewirth, Daniel T; Gierasch, Lila M; Houry, Walid A; Johnson, Jill L; Kang, Byoung Heon; Kao, Aimee W; LaPointe, Paul; Mattoo, Seema; McClellan, Amie J; Neckers, Leonard M; Prodromou, Chrisostomos; Rasola, Andrea; Sager, Rebecca A; Theodoraki, Maria A; Truman, Andrew W; Truttman, Matthias C; Zachara, Natasha E; Bourboulia, Dimitra; Mollapour, Mehdi; Woodford, Mark R

An update on the status of HSP90 inhibitors in cancer clinical trials

癌症临床试验中 HSP90 抑制剂的最新进展

Rastogi, Shraddha; Joshi, Abhinav; Sato, Nahoko; Lee, Sunmin; Lee, Min-Jung; Trepel, Jane B; Neckers, Len

Dual inhibition of oxidative phosphorylation and glycolysis exerts a synergistic antitumor effect on colorectal and gastric cancer by creating energy depletion and preventing metabolic switch

氧化磷酸化和糖酵解的双重抑制通过造成能量耗竭和阻止代谢转换,对结直肠癌和胃癌发挥协同抗肿瘤作用。

Aisu, Yuki; Oshima, Nobu; Hyodo, Fuminori; Elhelaly, Abdelazim Elsayed; Masuo, Akihiko; Okada, Tomoaki; Hisamori, Shigeo; Tsunoda, Shigeru; Hida, Koya; Morimoto, Tomonori; Miyoshi, Hiroyuki; Taketo, Makoto M; Matsuo, Masayuki; Neckers, Leonard M; Sakai, Yoshiharu; Obama, Kazutaka

Structural and functional complexity of HSP90 in cellular homeostasis and disease

HSP90在细胞稳态和疾病中的结构和功能复杂性

Chiosis, Gabriela; Digwal, Chander S; Trepel, Jane B; Neckers, Len

Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid

线粒体编码复合物 I 损伤可诱导甲状腺赫尔特尔细胞癌对有氧发酵产生靶向依赖性

Anderson R Frank, Vicky Li, Spencer D Shelton, Jiwoong Kim, Gordon M Stott, Leonard M Neckers, Yang Xie, Noelle S Williams, Prashant Mishra, David G McFadden

Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models

抑制NAD+依赖性代谢过程可诱导横纹肌肉瘤模型中的细胞坏死和肿瘤消退

McKay-Corkum, Grace B; Collins, Victor J; Yeung, Choh; Ito, Takeshi; Issaq, Sameer H; Holland, David; Vulikh, Ksenia; Zhang, Yiping; Lee, Unsun; Lei, Haiyan; Mendoza, Arnulfo; Shern, Jack F; Yohe, Marielle E; Yamamoto, Kazutoshi; Wilson, Kelli; Ji, Jiuping; Karim, Baktiar O; Thomas, Craig J; Krishna, Murali C; Neckers, Leonard M; Heske, Christine M

Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8-9, 2022

第二届细胞和机体应激反应虚拟国际研讨会,2022年9月8-9日

van Oosten-Hawle, Patricija; Backe, Sarah J; Ben-Zvi, Anat; Bourboulia, Dimitra; Brancaccio, Mara; Brodsky, Jeff; Clark, Melody; Colombo, Giorgio; Cox, Marc B; De Los Rios, Paolo; Echtenkamp, Frank; Edkins, Adrienne; Freeman, Brian; Goloubinoff, Pierre; Houry, Walid; Johnson, Jill; LaPointe, Paul; Li, Wei; Mezger, Valerie; Neckers, Len; Nillegoda, Nadinath B; Prahlad, Veena; Reitzel, Adam; Scherz-Shouval, Ruth; Sistonen, Lea; Tsai, Francis T F; Woodford, Mark R; Mollapour, Mehdi; Truman, Andrew W