日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Models of High-Grade Serous Ovarian Carcinoma

高级别浆液性卵巢癌模型

Pundel, Oscar J; Neel, Benjamin G

Characterization of tumour heterogeneity through segmentation-free representation learning on multiplexed imaging data.

通过对多重成像数据进行无分割表示学习来表征肿瘤异质性

Tan Jimin, Le Hortense, Deng Jiehui, Liu Yingzhuo, Hao Yuan, Hollenberg Michelle, Liu Wenke, Wang Joshua M, Xia Bo, Ramaswami Sitharam, Mezzano Valeria, Loomis Cynthia, Murrell Nina, Moreira Andre L, Cho Kyunghyun, Pass Harvey I, Wong Kwok-Kin, Ban Yi, Neel Benjamin G, Tsirigos Aristotelis, Fenyö David

Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models

星形胶质细胞中异常的ERK信号传导会损害RAS病相关BRAF突变小鼠模型的学习和记忆能力。

Kang, Minkyung; Choi, Jihye; Han, Jeongho; Araki, Toshiyuki; Kim, Soo-Whee; Ryu, Hyun-Hee; Kim, Min-Gyun; Kim, Seoyeon; Jang, Hanbyul; Kim, Sun Yong; Hwang, Kyoung-Doo; Kim, Soobin; Yoo, Myeongjong; Lee, Jaegeon; Kim, Kitae; Park, Pojeong; Choi, Ja Eun; Han, Dae Hee; Kim, Yujin; Kim, Jeongyeon; Chang, Sunghoe; Kaang, Bong-Kiun; Ko, Jung Min; Cheon, Keun-Ah; An, Joon-Yong; Kim, Sang Jeong; Park, Hyungju; Neel, Benjamin G; Kim, Chul Hoon; Lee, Yong-Seok

Generation of actionable, cancer-specific neoantigens from KRAS(G12C) with adagrasib.

利用阿达格拉西布从 KRAS(G12C) 生成可操作的、癌症特异性的新抗原。

Maso Lorenzo, Rajak Epsa, Hattori Takamitsu, Hu Zhengshan, Koide Akiko, Neel Benjamin G, Koide Shohei

T lymphocyte-specific deletion of SHP1 and SHP2 promotes activation-induced cell death of CD4(+) T cells and impairs antitumor response.

T 淋巴细胞特异性缺失 SHP1 和 SHP2 可促进 CD4(+) T 细胞的活化诱导细胞死亡,并损害抗肿瘤反应。

Foster Connor J R, Du Jasper, Pundel Oscar, Geer Mitchell J, Ripert Ryan C, Liu Jia, Heim Taylor A, Araki Kiyomi Y, Lund Amanda W, Wang Jun, Neel Benjamin G

Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors.

羟氯喹可防止耐药性,并增强 SHP2 抑制剂对 NF1 相关恶性周围神经鞘瘤的抗肿瘤作用

Sait Sameer Farouk, Tang Kwan Ho, Angus Steven P, Brown Rebecca, Sun Daochun, Xie Xuanhua, Iltis Charlene, Lien Michelle, D Socci Nicholas, Bale Tejus A, Davis Christopher, Dixon Shelley A H, Zhang Chi, Wade Clapp D, Neel Benjamin G, Parada Luis F

T Lymphocyte-Specific Deletion of SHP1 and SHP2 Promotes Activation-Induced Cell Death of CD4+ T Cells and Impairs Antitumor Response

T淋巴细胞特异性敲除SHP1和SHP2可促进CD4+ T细胞活化诱导的细胞死亡并削弱抗肿瘤反应。

Foster, Connor J R; Du, Jasper; Pundel, Oscar; Geer, Mitchell J; Ripert, Ryan C; Liu, Jia; Heim, Taylor A; Araki, Kiyomi Y; Lund, Amanda W; Wang, Jun; Neel, Benjamin G

Molecular basis for antibody recognition of multiple drug-peptide/MHC complexes

抗体识别多种药物-肽/MHC复合物的分子基础

Maso, Lorenzo; Rajak, Epsa; Bang, Injin; Koide, Akiko; Hattori, Takamitsu; Neel, Benjamin G; Koide, Shohei

The current state of the art and future trends in RAS-targeted cancer therapies

RAS靶向癌症治疗的现状及未来发展趋势

Punekar, Salman R; Velcheti, Vamsidhar; Neel, Benjamin G; Wong, Kwok-Kin

Computational modeling of ovarian cancer dynamics suggests optimal strategies for therapy and screening

卵巢癌动态的计算模型为治疗和筛查提供了最佳策略

Gu, Shengqing; Lheureux, Stephanie; Sayad, Azin; Cybulska, Paulina; Hogen, Liat; Vyarvelska, Iryna; Tu, Dongsheng; Parulekar, Wendy R; Nankivell, Matthew; Kehoe, Sean; Chi, Dennis S; Levine, Douglas A; Bernardini, Marcus Q; Rosen, Barry; Oza, Amit; Brown, Myles; Neel, Benjamin G