日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Leveraging Genomic Data to Examine the Causal Impact of Alcohol, Tobacco, Cannabis, and Opioid Use on Biological and Cognitive Ageing

利用基因组数据研究酒精、烟草、大麻和阿片类药物使用对生物和认知老化的因果影响

Balbona, Jared V; Jeffries, Paul; Gorelik, Aaron J; Nelson, Elliot C; Bogdan, Ryan; Agrawal, Arpana; Johnson, Emma C

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

全基因组关联分析鉴定出95个风险位点,并为创伤后应激障碍的神经生物学提供了新的见解。

Nievergelt, Caroline M; Maihofer, Adam X; Atkinson, Elizabeth G; Chen, Chia-Yen; Choi, Karmel W; Coleman, Jonathan R I; Daskalakis, Nikolaos P; Duncan, Laramie E; Polimanti, Renato; Aaronson, Cindy; Amstadter, Ananda B; Andersen, Soren B; Andreassen, Ole A; Arbisi, Paul A; Ashley-Koch, Allison E; Austin, S Bryn; Avdibegoviç, Esmina; Babić, Dragan; Bacanu, Silviu-Alin; Baker, Dewleen G; Batzler, Anthony; Beckham, Jean C; Belangero, Sintia; Benjet, Corina; Bergner, Carisa; Bierer, Linda M; Biernacka, Joanna M; Bierut, Laura J; Bisson, Jonathan I; Boks, Marco P; Bolger, Elizabeth A; Brandolino, Amber; Breen, Gerome; Bressan, Rodrigo Affonseca; Bryant, Richard A; Bustamante, Angela C; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Børglum, Anders D; Børte, Sigrid; Cahn, Leah; Calabrese, Joseph R; Caldas-de-Almeida, Jose Miguel; Chatzinakos, Chris; Cheema, Sheraz; Clouston, Sean A P; Colodro-Conde, Lucía; Coombes, Brandon J; Cruz-Fuentes, Carlos S; Dale, Anders M; Dalvie, Shareefa; Davis, Lea K; Deckert, Jürgen; Delahanty, Douglas L; Dennis, Michelle F; Desarnaud, Frank; DiPietro, Christopher P; Disner, Seth G; Docherty, Anna R; Domschke, Katharina; Dyb, Grete; Kulenović, Alma Džubur; Edenberg, Howard J; Evans, Alexandra; Fabbri, Chiara; Fani, Negar; Farrer, Lindsay A; Feder, Adriana; Feeny, Norah C; Flory, Janine D; Forbes, David; Franz, Carol E; Galea, Sandro; Garrett, Melanie E; Gelaye, Bizu; Gelernter, Joel; Geuze, Elbert; Gillespie, Charles F; Goleva, Slavina B; Gordon, Scott D; Goçi, Aferdita; Grasser, Lana Ruvolo; Guindalini, Camila; Haas, Magali; Hagenaars, Saskia; Hauser, Michael A; Heath, Andrew C; Hemmings, Sian M J; Hesselbrock, Victor; Hickie, Ian B; Hogan, Kelleigh; Hougaard, David Michael; Huang, Hailiang; Huckins, Laura M; Hveem, Kristian; Jakovljević, Miro; Javanbakht, Arash; Jenkins, Gregory D; Johnson, Jessica; Jones, Ian; Jovanovic, Tanja; Karstoft, Karen-Inge; Kaufman, Milissa L; Kennedy, James L; Kessler, Ronald C; Khan, Alaptagin; Kimbrel, Nathan A; King, Anthony P; Koen, Nastassja; Kotov, Roman; Kranzler, Henry R; Krebs, Kristi; Kremen, William S; Kuan, Pei-Fen; Lawford, Bruce R; Lebois, Lauren A M; Lehto, Kelli; Levey, Daniel F; Lewis, Catrin; Liberzon, Israel; Linnstaedt, Sarah D; Logue, Mark W; Lori, Adriana; Lu, Yi; Luft, Benjamin J; Lupton, Michelle K; Luykx, Jurjen J; Makotkine, Iouri; Maples-Keller, Jessica L; Marchese, Shelby; Marmar, Charles; Martin, Nicholas G; Martínez-Levy, Gabriela A; McAloney, Kerrie; McFarlane, Alexander; McLaughlin, Katie A; McLean, Samuel A; Medland, Sarah E; Mehta, Divya; Meyers, Jacquelyn; Michopoulos, Vasiliki; Mikita, Elizabeth A; Milani, Lili; Milberg, William; Miller, Mark W; Morey, Rajendra A; Morris, Charles Phillip; Mors, Ole; Mortensen, Preben Bo; Mufford, Mary S; Nelson, Elliot C; Nordentoft, Merete; Norman, Sonya B; Nugent, Nicole R; O'Donnell, Meaghan; Orcutt, Holly K; Pan, Pedro M; Panizzon, Matthew S; Pathak, Gita A; Peters, Edward S; Peterson, Alan L; Peverill, Matthew; Pietrzak, Robert H; Polusny, Melissa A; Porjesz, Bernice; Powers, Abigail; Qin, Xue-Jun; Ratanatharathorn, Andrew; Risbrough, Victoria B; Roberts, Andrea L; Rothbaum, Alex O; Rothbaum, Barbara O; Roy-Byrne, Peter; Ruggiero, Kenneth J; Rung, Ariane; Runz, Heiko; Rutten, Bart P F; de Viteri, Stacey Saenz; Salum, Giovanni Abrahão; Sampson, Laura; Sanchez, Sixto E; Santoro, Marcos; Seah, Carina; Seedat, Soraya; Seng, Julia S; Shabalin, Andrey; Sheerin, Christina M; Silove, Derrick; Smith, Alicia K; Smoller, Jordan W; Sponheim, Scott R; Stein, Dan J; Stensland, Synne; Stevens, Jennifer S; Sumner, Jennifer A; Teicher, Martin H; Thompson, Wesley K; Tiwari, Arun K; Trapido, Edward; Uddin, Monica; Ursano, Robert J; Valdimarsdóttir, Unnur; Van Hooff, Miranda; Vermetten, Eric; Vinkers, Christiaan H; Voisey, Joanne; Wang, Yunpeng; Wang, Zhewu; Waszczuk, Monika; Weber, Heike; Wendt, Frank R; Werge, Thomas; Williams, Michelle A; Williamson, Douglas E; Winsvold, Bendik S; Winternitz, Sherry; Wolf, Christiane; Wolf, Erika J; Xia, Yan; Xiong, Ying; Yehuda, Rachel; Young, Keith A; Young, Ross McD; Zai, Clement C; Zai, Gwyneth C; Zervas, Mark; Zhao, Hongyu; Zoellner, Lori A; Zwart, John-Anker; deRoon-Cassini, Terri; van Rooij, Sanne J H; van den Heuvel, Leigh L; Stein, Murray B; Ressler, Kerry J; Koenen, Karestan C

Examining the causal genetic effects of substance use on aging

研究物质滥用对衰老的因果遗传效应

Balbona, Jared V; Jeffries, Paul; Gorelik, Aaron J; Nelson, Elliot C; Bogdan, Ryan; Agrawal, Arpana; Johnson, Emma C

Cnih3 Deletion Dysregulates Dorsal Hippocampal Transcription across the Estrous Cycle

Cnih3 缺失导致动情周期中背侧海马转录失调

Mulvey, Bernard; Frye, Hannah E; Lintz, Tania; Fass, Stuart; Tycksen, Eric; Nelson, Elliot C; Morón, Jose A; Dougherty, Joseph D

Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information

通过整合定量表型和创伤暴露信息,增强创伤后应激障碍遗传变异的发现

Maihofer, Adam X; Choi, Karmel W; Coleman, Jonathan R I; Daskalakis, Nikolaos P; Denckla, Christy A; Ketema, Elizabeth; Morey, Rajendra A; Polimanti, Renato; Ratanatharathorn, Andrew; Torres, Katy; Wingo, Aliza P; Zai, Clement C; Aiello, Allison E; Almli, Lynn M; Amstadter, Ananda B; Andersen, Soren B; Andreassen, Ole A; Arbisi, Paul A; Ashley-Koch, Allison E; Austin, S Bryn; Avdibegović, Esmina; Borglum, Anders D; Babić, Dragan; Bækvad-Hansen, Marie; Baker, Dewleen G; Beckham, Jean C; Bierut, Laura J; Bisson, Jonathan I; Boks, Marco P; Bolger, Elizabeth A; Bradley, Bekh; Brashear, Meghan; Breen, Gerome; Bryant, Richard A; Bustamante, Angela C; Bybjerg-Grauholm, Jonas; Calabrese, Joseph R; Caldas-de-Almeida, José M; Chen, Chia-Yen; Dale, Anders M; Dalvie, Shareefa; Deckert, Jürgen; Delahanty, Douglas L; Dennis, Michelle F; Disner, Seth G; Domschke, Katharina; Duncan, Laramie E; Džubur Kulenović, Alma; Erbes, Christopher R; Evans, Alexandra; Farrer, Lindsay A; Feeny, Norah C; Flory, Janine D; Forbes, David; Franz, Carol E; Galea, Sandro; Garrett, Melanie E; Gautam, Aarti; Gelaye, Bizu; Gelernter, Joel; Geuze, Elbert; Gillespie, Charles F; Goçi, Aferdita; Gordon, Scott D; Guffanti, Guia; Hammamieh, Rasha; Hauser, Michael A; Heath, Andrew C; Hemmings, Sian M J; Hougaard, David Michael; Jakovljević, Miro; Jett, Marti; Johnson, Eric Otto; Jones, Ian; Jovanovic, Tanja; Qin, Xue-Jun; Karstoft, Karen-Inge; Kaufman, Milissa L; Kessler, Ronald C; Khan, Alaptagin; Kimbrel, Nathan A; King, Anthony P; Koen, Nastassja; Kranzler, Henry R; Kremen, William S; Lawford, Bruce R; Lebois, Lauren A M; Lewis, Catrin; Liberzon, Israel; Linnstaedt, Sarah D; Logue, Mark W; Lori, Adriana; Lugonja, Božo; Luykx, Jurjen J; Lyons, Michael J; Maples-Keller, Jessica L; Marmar, Charles; Martin, Nicholas G; Maurer, Douglas; Mavissakalian, Matig R; McFarlane, Alexander; McGlinchey, Regina E; McLaughlin, Katie A; McLean, Samuel A; Mehta, Divya; Mellor, Rebecca; Michopoulos, Vasiliki; Milberg, William; Miller, Mark W; Morris, Charles Phillip; Mors, Ole; Mortensen, Preben B; Nelson, Elliot C; Nordentoft, Merete; Norman, Sonya B; O'Donnell, Meaghan; Orcutt, Holly K; Panizzon, Matthew S; Peters, Edward S; Peterson, Alan L; Peverill, Matthew; Pietrzak, Robert H; Polusny, Melissa A; Rice, John P; Risbrough, Victoria B; Roberts, Andrea L; Rothbaum, Alex O; Rothbaum, Barbara O; Roy-Byrne, Peter; Ruggiero, Kenneth J; Rung, Ariane; Rutten, Bart P F; Saccone, Nancy L; Sanchez, Sixto E; Schijven, Dick; Seedat, Soraya; Seligowski, Antonia V; Seng, Julia S; Sheerin, Christina M; Silove, Derrick; Smith, Alicia K; Smoller, Jordan W; Sponheim, Scott R; Stein, Dan J; Stevens, Jennifer S; Teicher, Martin H; Thompson, Wesley K; Trapido, Edward; Uddin, Monica; Ursano, Robert J; van den Heuvel, Leigh Luella; Van Hooff, Miranda; Vermetten, Eric; Vinkers, Christiaan H; Voisey, Joanne; Wang, Yunpeng; Wang, Zhewu; Werge, Thomas; Williams, Michelle A; Williamson, Douglas E; Winternitz, Sherry; Wolf, Christiane; Wolf, Erika J; Yehuda, Rachel; Young, Keith A; Young, Ross McD; Zhao, Hongyu; Zoellner, Lori A; Haas, Magali; Lasseter, Heather; Provost, Allison C; Salem, Rany M; Sebat, Jonathan; Shaffer, Richard A; Wu, Tianying; Ripke, Stephan; Daly, Mark J; Ressler, Kerry J; Koenen, Karestan C; Stein, Murray B; Nievergelt, Caroline M

Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond

阿片类药物成瘾的多性状全基因组关联研究:OPRM1 及其他

Gaddis, Nathan; Mathur, Ravi; Marks, Jesse; Zhou, Linran; Quach, Bryan; Waldrop, Alex; Levran, Orna; Agrawal, Arpana; Randesi, Matthew; Adelson, Miriam; Jeffries, Paul W; Martin, Nicholas G; Degenhardt, Louisa; Montgomery, Grant W; Wetherill, Leah; Lai, Dongbing; Bucholz, Kathleen; Foroud, Tatiana; Porjesz, Bernice; Runarsdottir, Valgerdur; Tyrfingsson, Thorarinn; Einarsson, Gudmundur; Gudbjartsson, Daniel F; Webb, Bradley Todd; Crist, Richard C; Kranzler, Henry R; Sherva, Richard; Zhou, Hang; Hulse, Gary; Wildenauer, Dieter; Kelty, Erin; Attia, John; Holliday, Elizabeth G; McEvoy, Mark; Scott, Rodney J; Schwab, Sibylle G; Maher, Brion S; Gruza, Richard; Kreek, Mary Jeanne; Nelson, Elliot C; Thorgeirsson, Thorgeir; Stefansson, Kari; Berrettini, Wade H; Gelernter, Joel; Edenberg, Howard J; Bierut, Laura; Hancock, Dana B; Johnson, Eric Otto

Sex Differences in the Role of CNIH3 on Spatial Memory and Synaptic Plasticity.

CNIH3 在空间记忆和突触可塑性中的作用存在性别差异

Frye Hannah E, Izumi Yukitoshi, Harris Alexis N, Williams Sidney B, Trousdale Christopher R, Sun Min-Yu, Sauerbeck Andrew D, Kummer Terrance T, Mennerick Steven, Zorumski Charles F, Nelson Elliot C, Dougherty Joseph D, Morón Jose A

Using Monozygotic Twins to Dissect Common Genes in Posttraumatic Stress Disorder and Migraine

利用同卵双胞胎剖析创伤后应激障碍和偏头痛的共同基因

Bainomugisa, Charlotte K; Sutherland, Heidi G; Parker, Richard; Mcrae, Allan F; Haupt, Larisa M; Griffiths, Lyn R; Heath, Andrew; Nelson, Elliot C; Wright, Margaret J; Hickie, Ian B; Martin, Nicholas G; Nyholt, Dale R; Mehta, Divya

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

饮食障碍和物质使用相关表型之间存在共同的遗传风险:来自全基因组关联研究的证据

Munn-Chernoff, Melissa A; Johnson, Emma C; Chou, Yi-Ling; Coleman, Jonathan R I; Thornton, Laura M; Walters, Raymond K; Yilmaz, Zeynep; Baker, Jessica H; Hübel, Christopher; Gordon, Scott; Medland, Sarah E; Watson, Hunna J; Gaspar, Héléna A; Bryois, Julien; Hinney, Anke; Leppä, Virpi M; Mattheisen, Manuel; Ripke, Stephan; Yao, Shuyang; Giusti-Rodríguez, Paola; Hanscombe, Ken B; Adan, Roger A H; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole A; Berrettini, Wade H; Boehm, Ilka; Boni, Claudette; Boraska Perica, Vesna; Buehren, Katharina; Burghardt, Roland; Cassina, Matteo; Cichon, Sven; Clementi, Maurizio; Cone, Roger D; Courtet, Philippe; Crow, Scott; Crowley, James J; Danner, Unna N; Davis, Oliver S P; de Zwaan, Martina; Dedoussis, George; Degortes, Daniela; DeSocio, Janiece E; Dick, Danielle M; Dikeos, Dimitris; Dina, Christian; Dmitrzak-Weglarz, Monika; Docampo, Elisa; Duncan, Laramie E; Egberts, Karin; Ehrlich, Stefan; Escaramís, Geòrgia; Esko, Tõnu; Estivill, Xavier; Farmer, Anne; Favaro, Angela; Fernández-Aranda, Fernando; Fichter, Manfred M; Fischer, Krista; Föcker, Manuel; Foretova, Lenka; Forstner, Andreas J; Forzan, Monica; Franklin, Christopher S; Gallinger, Steven; Giegling, Ina; Giuranna, Johanna; Gonidakis, Fragiskos; Gorwood, Philip; Gratacos Mayora, Monica; Guillaume, Sébastien; Guo, Yiran; Hakonarson, Hakon; Hatzikotoulas, Konstantinos; Hauser, Joanna; Hebebrand, Johannes; Helder, Sietske G; Herms, Stefan; Herpertz-Dahlmann, Beate; Herzog, Wolfgang; Huckins, Laura M; Hudson, James I; Imgart, Hartmut; Inoko, Hidetoshi; Janout, Vladimir; Jiménez-Murcia, Susana; Julià, Antonio; Kalsi, Gursharan; Kaminská, Deborah; Karhunen, Leila; Karwautz, Andreas; Kas, Martien J H; Kennedy, James L; Keski-Rahkonen, Anna; Kiezebrink, Kirsty; Kim, Youl-Ri; Klump, Kelly L; Knudsen, Gun Peggy S; La Via, Maria C; Le Hellard, Stephanie; Levitan, Robert D; Li, Dong; Lilenfeld, Lisa; Lin, Bochao Danae; Lissowska, Jolanta; Luykx, Jurjen; Magistretti, Pierre J; Maj, Mario; Mannik, Katrin; Marsal, Sara; Marshall, Christian R; Mattingsdal, Morten; McDevitt, Sara; McGuffin, Peter; Metspalu, Andres; Meulenbelt, Ingrid; Micali, Nadia; Mitchell, Karen; Monteleone, Alessio Maria; Monteleone, Palmiero; Nacmias, Benedetta; Navratilova, Marie; Ntalla, Ioanna; O'Toole, Julie K; Ophoff, Roel A; Padyukov, Leonid; Palotie, Aarno; Pantel, Jacques; Papezova, Hana; Pinto, Dalila; Rabionet, Raquel; Raevuori, Anu; Ramoz, Nicolas; Reichborn-Kjennerud, Ted; Ricca, Valdo; Ripatti, Samuli; Ritschel, Franziska; Roberts, Marion; Rotondo, Alessandro; Rujescu, Dan; Rybakowski, Filip; Santonastaso, Paolo; Scherag, André; Scherer, Stephen W; Schmidt, Ulrike; Schork, Nicholas J; Schosser, Alexandra; Seitz, Jochen; Slachtova, Lenka; Slagboom, P Eline; Slof-Op't Landt, Margarita C T; Slopien, Agnieszka; Sorbi, Sandro; Świątkowska, Beata; Szatkiewicz, Jin P; Tachmazidou, Ioanna; Tenconi, Elena; Tortorella, Alfonso; Tozzi, Federica; Treasure, Janet; Tsitsika, Artemis; Tyszkiewicz-Nwafor, Marta; Tziouvas, Konstantinos; van Elburg, Annemarie A; van Furth, Eric F; Wagner, Gudrun; Walton, Esther; Widen, Elisabeth; Zeggini, Eleftheria; Zerwas, Stephanie; Zipfel, Stephan; Bergen, Andrew W; Boden, Joseph M; Brandt, Harry; Crawford, Steven; Halmi, Katherine A; Horwood, L John; Johnson, Craig; Kaplan, Allan S; Kaye, Walter H; Mitchell, James; Olsen, Catherine M; Pearson, John F; Pedersen, Nancy L; Strober, Michael; Werge, Thomas; Whiteman, David C; Woodside, D Blake; Grove, Jakob; Henders, Anjali K; Larsen, Janne T; Parker, Richard; Petersen, Liselotte V; Jordan, Jennifer; Kennedy, Martin A; Birgegård, Andreas; Lichtenstein, Paul; Norring, Claes; Landén, Mikael; Mortensen, Preben Bo; Polimanti, Renato; McClintick, Jeanette N; Adkins, Amy E; Aliev, Fazil; Bacanu, Silviu-Alin; Batzler, Anthony; Bertelsen, Sarah; Biernacka, Joanna M; Bigdeli, Tim B; Chen, Li-Shiun; Clarke, Toni-Kim; Degenhardt, Franziska; Docherty, Anna R; Edwards, Alexis C; Foo, Jerome C; Fox, Louis; Frank, Josef; Hack, Laura M; Hartmann, Annette M; Hartz, Sarah M; Heilmann-Heimbach, Stefanie; Hodgkinson, Colin; Hoffmann, Per; Hottenga, Jouke-Jan; Konte, Bettina; Lahti, Jari; Lahti-Pulkkinen, Marius; Lai, Dongbing; Ligthart, Lannie; Loukola, Anu; Maher, Brion S; Mbarek, Hamdi; McIntosh, Andrew M; McQueen, Matthew B; Meyers, Jacquelyn L; Milaneschi, Yuri; Palviainen, Teemu; Peterson, Roseann E; Ryu, Euijung; Saccone, Nancy L; Salvatore, Jessica E; Sanchez-Roige, Sandra; Schwandt, Melanie; Sherva, Richard; Streit, Fabian; Strohmaier, Jana; Thomas, Nathaniel; Wang, Jen-Chyong; Webb, Bradley T; Wedow, Robbee; Wetherill, Leah; Wills, Amanda G; Zhou, Hang; Boardman, Jason D; Chen, Danfeng; Choi, Doo-Sup; Copeland, William E; Culverhouse, Robert C; Dahmen, Norbert; Degenhardt, Louisa; Domingue, Benjamin W; Frye, Mark A; Gäebel, Wolfgang; Hayward, Caroline; Ising, Marcus; Keyes, Margaret; Kiefer, Falk; Koller, Gabriele; Kramer, John; Kuperman, Samuel; Lucae, Susanne; Lynskey, Michael T; Maier, Wolfgang; Mann, Karl; Männistö, Satu; Müller-Myhsok, Bertram; Murray, Alison D; Nurnberger, John I; Preuss, Ulrich; Räikkönen, Katri; Reynolds, Maureen D; Ridinger, Monika; Scherbaum, Norbert; Schuckit, Marc A; Soyka, Michael; Treutlein, Jens; Witt, Stephanie H; Wodarz, Norbert; Zill, Peter; Adkins, Daniel E; Boomsma, Dorret I; Bierut, Laura J; Brown, Sandra A; Bucholz, Kathleen K; Costello, E Jane; de Wit, Harriet; Diazgranados, Nancy; Eriksson, Johan G; Farrer, Lindsay A; Foroud, Tatiana M; Gillespie, Nathan A; Goate, Alison M; Goldman, David; Grucza, Richard A; Hancock, Dana B; Harris, Kathleen Mullan; Hesselbrock, Victor; Hewitt, John K; Hopfer, Christian J; Iacono, William G; Johnson, Eric O; Karpyak, Victor M; Kendler, Kenneth S; Kranzler, Henry R; Krauter, Kenneth; Lind, Penelope A; McGue, Matt; MacKillop, James; Madden, Pamela A F; Maes, Hermine H; Magnusson, Patrik K E; Nelson, Elliot C; Nöthen, Markus M; Palmer, Abraham A; Penninx, Brenda W J H; Porjesz, Bernice; Rice, John P; Rietschel, Marcella; Riley, Brien P; Rose, Richard J; Shen, Pei-Hong; Silberg, Judy; Stallings, Michael C; Tarter, Ralph E; Vanyukov, Michael M; Vrieze, Scott; Wall, Tamara L; Whitfield, John B; Zhao, Hongyu; Neale, Benjamin M; Wade, Tracey D; Heath, Andrew C; Montgomery, Grant W; Martin, Nicholas G; Sullivan, Patrick F; Kaprio, Jaakko; Breen, Gerome; Gelernter, Joel; Edenberg, Howard J; Bulik, Cynthia M; Agrawal, Arpana

Exploring the genetic overlap of suicide-related behaviors and substance use disorders

探索自杀相关行为和物质使用障碍的遗传重叠

Colbert, Sarah M C; Hatoum, Alexander S; Shabalin, Andrey; Li, Qingqin S; Coon, Hilary; Nelson, Elliot C; Agrawal, Arpana; Docherty, Anna R; Johnson, Emma C