日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK

汤姆·康纳斯教授与英国癌症研究中心I/II期临床试验委员会共同开发新型癌症疗法

Newell, D R; Searle, K M; Westwood, N B; Burtles, S S

Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro

聚(ADP-核糖)聚合酶(PARP)抑制剂NU1025对L1210细胞中拓扑异构酶I和II抑制剂细胞毒性的体外差异性影响

Bowman, K J; Newell, D R; Calvert, A H; Curtin, N J

Induction of apoptosis by the ADEPT agent ZD2767: comparison with the classical nitrogen mustard chlorambucil and a monofunctional ZD2767 analogue.

ADEPT 药物 ZD2767 诱导细胞凋亡:与经典氮芥类药物苯丁酸氮芥和单功能 ZD2767 类似物的比较

Monks N R, Blakey D C, Curtin N J, East S J, Heuze A, Newell D R

Dipyridamole potentiates the in vitro activity of MTA (LY231514) by inhibition of thymidine transport.

双嘧达莫通过抑制胸苷转运增强 MTA (LY231514) 的体外活性

Smith P G, Marshman E, Newell D R, Curtin N J

Evaluation of rodent-only toxicology for early clinical trials with novel cancer therapeutics

仅使用啮齿动物进行新型癌症疗法早期临床试验的毒理学评估

Newell, D R; Burtles, S S; Fox, B W; Jodrell, D I; Connors, T A

Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding

双嘧达莫类似物通过降低α1-酸性糖蛋白结合能力增强胸苷酸合成酶(TS)抑制剂的细胞毒性

Curtin, N J; Bowman, K J; Turner, R N; Huang, B; Loughlin, P J; Calvert, A H; Golding, B T; Griffin, R J; Newell, D R

O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma

治疗前肿瘤活检中 O6-甲基鸟嘌呤-DNA 甲基转移酶作为黑色素瘤对替莫唑胺治疗反应的预测因子

Middleton, M R; Lunn, J M; Morris, C; Rustin, G; Wedge, S R; Brampton, M H; Lind, M J; Lee, S M; Newell, D R; Bleehen, N M; Newlands, E S; Calvert, A H; Margison, G P; Thatcher, N

The renal effects of N10-propargyl-5,8-dideazafolic acid (CB3717) and a non-nephrotoxic analogue ICI D1694, in mice

N10-丙炔基-5,8-二脱氮叶酸 (CB3717) 及其非肾毒性类似物 ICI D1694 对小鼠肾脏的影响

Jodrell, D I; Newell, D R; Morgan, S E; Clinton, S; Bensted, J P; Hughes, L R; Calvert, A H

Pharmacokinetic studies with the antifolate C2-desamino-C2-methyl-N10-propargyl-2'-trifluoromethyl-5,8-dideazafolic acid (CB3988) in mice and rats using in vivo 19F-NMR spectroscopy

利用体内19F-NMR光谱法对抗叶酸药物C2-脱氨基-C2-甲基-N10-丙炔基-2'-三氟甲基-5,8-二脱氮叶酸(CB3988)在小鼠和大鼠体内的药代动力学进行了研究

Newell, D R; Maxwell, R J; Bisset, G M; Jodrell, D I; Griffiths, J R

Studies on the pharmacokinetics of chlorambucil and prednimustine in man

氯苯丁酸氮芥和泼尼莫司汀在人体内的药代动力学研究

Newell, D R; Calvert, A H; Harrap, K R; McElwain, T J