日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TMOD-40. Genetic drivers shape tumor phenotype and composition of the tumor microenvironment in syngeneic mouse models of glioblastoma

TMOD-40。遗传驱动因素塑造胶质母细胞瘤同源小鼠模型中的肿瘤表型和肿瘤微环境组成。

Mathew, Divij; Ohri, Nitin; Ngiow, Shin Foong; Halmos, Balazs; Wumesh, K C; Garg, Madhur; Levsky, Jeffrey M; Cheng, Haiying; Gucalp, Rasim A; Bodner, William Raymond; Kabarriti, Rafi; Gutierrez-Chavez, Claudia; Zakharia, Adel; Kalnicki, Shalom; Keler, Tibor; Yellin, Michael; Minn, Andy J; Maity, Amit; Giles, Josephine R; Guha, Chandan; Wherry, E John; Lu, Zhongyan; Parsons, Emily; Richard, Stephanie A; Alba, Camille; Sukumar, Gauthaman; Rosenberger, John; Zhang, Xijun; Burgess, Timothy; Agan, Brian; Dalgard, Clifton; Pollett, Simon; Malloy, Allison M; Pyczek, Joanna; Snelling, Shannon; Lun, Xueqing; Ahn, Bo Young; Seo, Heewon; Yu, Miranda; Quail, Daniela; Morrissy, A Sorana; Chan, Jennifer A

In vivo reprogramming of cytotoxic effector CD8 (+) T cells via fractalkine-conjugated mRNA-LNP

通过趋化因子偶联的mRNA-LNP对细胞毒性效应CD8(+) T细胞进行体内重编程

Corrigan, Angela R; Ngiow, Shin Foong; Statzu, Maura; Pampena, Maria Betina; Nordin, Jayme M L; Albertus, Amie; Carro, Stephen D; Harper, Justin; Stammen, Rachelle L; Wood, Jennifer; Hamilton, Jacob T; Ni, Houping; Su, Justin; Ramalingam, Rajesvaran; Wu, Vincent H; Paiardini, Mirko; Weissman, Drew; Wherry, E John; Kreider, Edward F; Betts, Michael R

Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8(+) T cells underlies distinct functional potential.

组织驻留记忆 CD8(+) T 细胞和组织驻留耗竭 CD8(+) T 细胞不同的个体发育过程决定了它们不同的功能潜力

Park Simone L, Painter Mark M, Manne Sasikanth, Alcalde Victor, McLaughlin Maura, Sullivan Matthew A, Mathew Divij, Torres Leonel, Huang Yinghui J, Reeg David B, Douek Naomi R, Campos Trenton, Klapholz Max, Cardenas Maria A, Fang Victoria, Ngiow Shin Foong, Kc Wumesh, Goel Rishi R, Baxter Amy E, Wu Jennifer E, Tan Melody, Berry Corbett T, Ellebrecht Christoph T, Huang Alexander C, Papazian Emily, Liu Ying, Rajasekaran Karthik, Brody Robert M, Thaler Erica R, Basu Devraj, Diab Ahmed, Giles Josephine R, Wherry E John

LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity

LAG-3 维持 TOX 表达并调节 CD94/NKG2-Qa-1b 轴,从而控制耗竭 CD8 T 细胞 NK 受体的表达和细胞毒性。

Shin Foong Ngiow ,Sasikanth Manne ,Yinghui Jane Huang ,Tarek Azar ,Zeyu Chen ,Divij Mathew ,Qingzhou Chen ,Omar Khan ,Jennifer E Wu ,Victor Alcalde ,Ahron J Flowers ,Sean McClain ,Amy E Baxter ,Makoto Kurachi ,Junwei Shi ,Alexander C Huang ,Josephine R Giles ,Arlene H Sharpe ,Dario A A Vignali ,E John Wherry

LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

LAG-3 和 PD-1 在 CD8+ T 细胞上发挥协同作用,导致 T 细胞耗竭并抑制自分泌 IFN-γ 依赖性抗肿瘤免疫。

Lawrence P Andrews ,Samuel C Butler ,Jian Cui ,Anthony R Cillo ,Carly Cardello ,Chang Liu ,Erin A Brunazzi ,Andrew Baessler ,Bingxian Xie ,Sheryl R Kunning ,Shin Foong Ngiow ,Yinghui Jane Huang ,Sasikanth Manne ,Arlene H Sharpe ,Greg M Delgoffe ,E John Wherry ,John M Kirkwood ,Tulia C Bruno ,Creg J Workman ,Dario A A Vignali

Combined JAK inhibition and PD-1 immunotherapy for non-small cell lung cancer patients

JAK 抑制和 PD-1 免疫治疗联合治疗非小细胞肺癌患者

Divij Mathew #, Melina E Marmarelis #, Caitlin Foley, Joshua M Bauml, Darwin Ye, Reem Ghinnagow, Shin Foong Ngiow, Max Klapholz, Soyeong Jun, Zhaojun Zhang, Robert Zorc, Christiana W Davis, Maximillian Diehn, Josephine R Giles, Alexander C Huang, Wei-Ting Hwang, Nancy R Zhang, Adam J Schoenfeld, Eri

TIGIT predominantly regulates the immune response via regulatory T cells

TIGIT主要通过调节性T细胞来调节免疫反应。

Kurtulus, Sema; Sakuishi, Kaori; Ngiow, Shin-Foong; Joller, Nicole; Tan, Dewar J; Teng, Michele Wl; Smyth, Mark J; Kuchroo, Vijay K; Anderson, Ana C

Serotonin reduction in post-acute sequelae of viral infection

病毒感染急性后遗症中血清素水平降低

Andrea C Wong ,Ashwarya S Devason ,Iboro C Umana ,Timothy O Cox ,Lenka Dohnalová ,Lev Litichevskiy ,Jonathan Perla ,Patrick Lundgren ,Zienab Etwebi ,Luke T Izzo ,Jihee Kim ,Monika Tetlak ,Hélène C Descamps ,Simone L Park ,Stephen Wisser ,Aaron D McKnight ,Ryan D Pardy ,Junwon Kim ,Niklas Blank ,Shaan Patel ,Katharina Thum ,Sydney Mason ,Jean-Christophe Beltra ,Michaël F Michieletto ,Shin Foong Ngiow ,Brittany M Miller ,Megan J Liou ,Bhoomi Madhu ,Oxana Dmitrieva-Posocco ,Alex S Huber ,Peter Hewins ,Christopher Petucci ,Candice P Chu ,Gwen Baraniecki-Zwil ,Leila B Giron ,Amy E Baxter ,Allison R Greenplate ,Charlotte Kearns ,Kathleen Montone ,Leslie A Litzky ,Michael Feldman ,Jorge Henao-Mejia ,Boris Striepen ,Holly Ramage ,Kellie A Jurado ,Kathryn E Wellen ,Una O'Doherty ,Mohamed Abdel-Mohsen ,Alan L Landay ,Ali Keshavarzian ,Timothy J Henrich ,Steven G Deeks ,Michael J Peluso ,Nuala J Meyer ,E John Wherry ,Benjamin A Abramoff ,Sara Cherry ,Christoph A Thaiss ,Maayan Levy

Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure

Stat5 拮抗转录因子 Tox,并在慢性抗原暴露期间将耗竭的 CD8+ T 细胞重塑为持久的效应样状态。

Jean-Christophe Beltra ,Mohamed S Abdel-Hakeem ,Sasikanth Manne ,Zhen Zhang ,Hua Huang ,Makoto Kurachi ,Leon Su ,Lora Picton ,Shin Foong Ngiow ,Yuki Muroyama ,Valentina Casella ,Yinghui J Huang ,Josephine R Giles ,Divij Mathew ,Jonathan Belman ,Max Klapholz ,Hélène Decaluwe ,Alexander C Huang ,Shelley L Berger ,K Christopher Garcia ,E John Wherry

In vitro modeling of CD8(+) T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40

体外模拟 CD8(+) T 细胞耗竭,使得 CRISPR 筛选能够揭示 BHLHE40 的作用。

Wu, Jennifer E; Manne, Sasikanth; Ngiow, Shin Foong; Baxter, Amy E; Huang, Hua; Freilich, Elizabeth; Clark, Megan L; Lee, Joanna H; Chen, Zeyu; Khan, Omar; Staupe, Ryan P; Huang, Yinghui J; Shi, Junwei; Giles, Josephine R; Wherry, E John