日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Two Structurally Distinct Classes of Inhibitors Targeting the Nuclease MUS81 and Enhancing Efficacy of Chemotherapy in Cancer Cells

发现两类结构不同的MUS81核酸酶抑制剂,可增强化疗对癌细胞的疗效

Prochazkova, Jana; Carbain, Benoit; Marini, Victoria; Nikulenkov, Fedor; Havel, Stepan; Akavaram, Naresh; Khirsariya, Prashant; Sisakova, Alexandra; Cibulka, Jakub; Boudova, Michala; Zacpalova, Magdalena; Kalovska, Magdalena; Rodrigues, Joana; Daniel, Lukas; Brezovsky, Jan; Bartunek, Petr; Azzalin, Claus; Paruch, Kamil; Krejci, Lumir

RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair

RAD51功能分离突变会破坏复制叉的维持,但保留DSB修复功能。

Mi Young Son,Ondrej Belan,Mario Spirek,Jakub Cibulka,Fedor Nikulenkov,You Young Kim,Sunyoung Hwang,Kyungjae Myung,Cristina Montagna,Tae Moon Kim,Lumir Krejci,Paul Hasty

MUS81 cleaves TOP1-derived lesions and other DNA-protein cross-links

MUS81 切割 TOP1 衍生的损伤和其他 DNA-蛋白质交联

Victoria Marini, Fedor Nikulenkov, Pounami Samadder, Sissel Juul, Birgitta R Knudsen, Lumir Krejci

DSS1 interacts with and stimulates RAD52 to promote the repair of DSBs

DSS1 与 RAD52 相互作用并刺激 RAD52,从而促进 DSB 的修复。

Stefanovie, Barbora; Hengel, Sarah R; Mlcouskova, Jarmila; Prochazkova, Jana; Spirek, Mario; Nikulenkov, Fedor; Nemecek, Daniel; Koch, Brandon G; Bain, Fletcher E; Yu, Liping; Spies, Maria; Krejci, Lumir

Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome

小鼠组蛋白macroH2A1.1的缺乏和单倍体不足可重现人类骨髓增生异常综合征的造血缺陷

Bereshchenko, Oxana; Lo Re, Oriana; Nikulenkov, Fedor; Flamini, Sara; Kotaskova, Jana; Mazza, Tommaso; Le Pannérer, Marguerite-Marie; Buschbeck, Marcus; Giallongo, Cesarina; Palumbo, Giuseppe; Li Volti, Giovanni; Pazienza, Valerio; Cervinek, Libor; Riccardi, Carlo; Krejci, Lumir; Pospisilova, Sarka; Stewart, A Francis; Vinciguerra, Manlio

Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation

具有不寻常的 N-三氟甲基吡唑药效团且对代谢 N-脱烷基化具有抗性的新型强效 CHK1 激酶选择性抑制剂的合成与分析

Pounami Samadder, Tereza Suchánková, Ondřej Hylse, Prashant Khirsariya, Fedor Nikulenkov, Stanislav Drápela, Nicol Straková, Petr Vaňhara, Kateřina Vašíčková, Hana Kolářová, Lucia Binó, Miroslava Bittová, Petra Ovesná, Peter Kollár, Radek Fedr, Milan Ešner, Josef Jaroš, Aleš Hampl, Lumír Krejčí, Kam

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

ROS 依赖的 JNK 激活将 p53 转化为致癌基因的有效抑制剂,从而导致细胞凋亡

Y Shi, F Nikulenkov, J Zawacka-Pankau, H Li, R Gabdoulline, J Xu, S Eriksson, E Hedström, N Issaeva, A Kel, E S J Arnér, G Selivanova

Lif1 SUMOylation and its role in non-homologous end-joining

Lif1 SUMO化及其在非同源末端连接中的作用

Dana Vigasova, Prabha Sarangi, Peter Kolesar, Danusa Vlasáková, Zuzana Slezakova, Veronika Altmannova, Fedor Nikulenkov, Dorothea Anrather, Rainer Gith, Xiaolan Zhao, Miroslav Chovanec, Lumir Krejci

Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

通过全基因组染色质占有率和基因表达分析深入了解 p53 转录功能

F Nikulenkov, C Spinnler, H Li, C Tonelli, Y Shi, M Turunen, T Kivioja, I Ignatiev, A Kel, J Taipale, G Selivanova

Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX

RITA 激活的 p53 抑制 Wip1 表达可增强 ATM 激活和 HdmX 诱导的细胞凋亡

C Spinnler, E Hedström, H Li, J de Lange, F Nikulenkov, A F A S Teunisse, M Verlaan-de Vries, V Grinkevich, A G Jochemsen, G Selivanova