日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR-Cas9 ribonucleoprotein

利用脂质纳米颗粒递送稳定的 CRISPR-Cas9 核糖核蛋白进行肺和肝脏基因编辑

Kai Chen # ,Hesong Han # ,Sheng Zhao ,Bryant Xu ,Boyan Yin ,Atip Lawanprasert ,Marena Trinidad ,Benjamin W Burgstone ,Niren Murthy ,Jennifer A Doudna

Characterizing and controlling CRISPR repair outcomes in nondividing human cells

对非分裂人类细胞中 CRISPR 修复结果进行表征和控制

Gokul N Ramadoss,Samali J Namaganda,Manasi M Kumar,Jennifer R Hamilton,Rohit Sharma,Karena G Chow,Luke A Workley,Bria L Macklin,Mengyuan Sun,Alvin S Ha,Jia-Cheng Liu,Christof Fellmann,Hannah L Watry,Philip H Dierks,Rudra S Bose,Julianne Jin,Barbara S Perez,Cindy R Sandoval Espinoza,Madeline P Matia,Serena H Lu,Luke M Judge,Brian R Shy,Andre Nussenzweig,Britt Adamson,Niren Murthy,Jennifer A Doudna,Martin Kampmann,Bruce R Conklin

Widespread Gene Editing in the Brain via In Utero Delivery of mRNA Using Acid-Degradable Lipid Nanoparticles

利用酸可降解脂质纳米粒子在子宫内递送 mRNA,实现大脑的广泛基因编辑

Kewa Gao, Hesong Han, Matileen G Cranick, Sheng Zhao, Shanxiu Xu, Boyan Yin, Hengyue Song, Yibo Hu, Maria T Clarke, David Wang, Jessica M Wong, Zehua Zhao, Benjamin W Burgstone, Diana L Farmer, Niren Murthy, Aijun Wang

In utero delivery of mRNA to the heart, diaphragm and muscle with lipid nanoparticles

利用脂质纳米颗粒在子宫内将 mRNA 递送至心脏、横膈膜和肌肉

Kewa Gao, Jie Li, Hengyue Song, Hesong Han, Yongheng Wang, Boyan Yin, Diana L Farmer, Niren Murthy, Aijun Wang

TAxI-peptide targeted Cas12a ribonuclease protein nanoformulations increase genome editing in hippocampal neurons

TAxI肽靶向Cas12a核糖核酸酶蛋白纳米制剂可增强海马神经元中的基因组编辑

Drew L Sellers ,Kunwoo Lee ,Niren Murthy ,Suzie H Pun

Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication

巯基嘧啶是木瓜蛋白酶样蛋白酶 (PLpro) 的可逆共价抑制剂,可抑制 SARS-CoV-2 (SCoV-2) 复制

Teena Bajaj, Eddie Wehri, Rahul K Suryawanshi, Elizabeth King, Kundan Singh Pardeshi, Kamyar Behrouzi, Zahra Khodabakhshi, Ursula Schulze-Gahmen, G Renuka Kumar, Mohammad R K Mofrad, Daniel K Nomura, Melanie Ott, Julia Schaletzky, Niren Murthy

Lipid Nanoparticles Deliver mRNA to the Brain after an Intracerebral Injection

脂质纳米颗粒经脑内注射后可将mRNA递送至大脑

Jan Tuma ,Yu-Ju Chen ,Michael G Collins ,Abhik Paul ,Jie Li ,Hesong Han ,Rohit Sharma ,Niren Murthy ,Hye Young Lee

The Coiled-Coil Forming Peptide (KVSALKE)5 Is a Cell Penetrating Peptide that Enhances the Intracellular Delivery of Proteins

卷曲螺旋形成肽(KVSALKE)5 是一种细胞穿透肽,可增强蛋白质的细胞内递送。

Jie Li ,Jan Tuma ,Hesong Han ,Hansol Kim ,Ross C Wilson ,Hye Young Lee ,Niren Murthy

Detection of unamplified target genes via CRISPR-Cas9 immobilized on a graphene field-effect transistor

通过固定在石墨烯场效应晶体管上的 CRISPR-Cas9 检测未扩增的靶基因

Reza Hajian, Sarah Balderston, Thanhtra Tran, Tara deBoer, Jessy Etienne, Mandeep Sandhu, Noreen A Wauford, Jing-Yi Chung, Jolie Nokes, Mitre Athaiya, Jacobo Paredes, Regis Peytavi, Brett Goldsmith, Niren Murthy, Irina M Conboy, Kiana Aran

Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours

将 CRISPR 纳米颗粒递送至大脑,拯救了患有脆性 X 综合征的小鼠模型,使其摆脱夸张的重复行为

Bumwhee Lee, Kunwoo Lee, Shree Panda, Rodrigo Gonzales-Rojas, Anthony Chong, Vladislav Bugay, Hyo Min Park, Robert Brenner, Niren Murthy, Hye Young Lee