日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases

对有毒和无毒错误折叠蛋白寡聚体对的表征阐明了蛋白质错误折叠疾病中寡聚体毒性的结构决定因素

Limbocker, Ryan; Cremades, Nunilo; Cascella, Roberta; Tessier, Peter M; Vendruscolo, Michele; Chiti, Fabrizio

Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau

α-突触核蛋白与 tau 同步静电凝聚和共聚集的分子机制

Pablo Gracia #, David Polanco #, Jorge Tarancón-Díez, Ilenia Serra, Maruan Bracci, Javier Oroz, Douglas V Laurents, Inés García, Nunilo Cremades

Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies

突触核蛋白病中寡聚体毒性、原纤维毒性和原纤维扩散的影响

Cascella, Roberta; Bigi, Alessandra; Cremades, Nunilo; Cecchi, Cristina

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

α-突触核蛋白原纤维释放的有毒低聚物会导致神经元细胞功能障碍

Roberta Cascella, Serene W Chen, Alessandra Bigi, José D Camino, Catherine K Xu, Christopher M Dobson, Fabrizio Chiti, Nunilo Cremades, Cristina Cecchi

All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species

通过分子伴侣触发的纤维解链进行的全或无淀粉样蛋白分解有利于清除 α-突触核蛋白毒性物质

Aitor Franco, Pablo Gracia, Adai Colom, José D Camino, José Ángel Fernández-Higuero, Natalia Orozco, Alexander Dulebo, Leonor Saiz, Nunilo Cremades, Jose M G Vilar, Adelina Prado, Arturo Muga

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

Trodusquemine通过一种通用机制将错误折叠的蛋白质寡聚体从细胞膜上置换下来,并消除其细胞毒性。

Limbocker, Ryan; Mannini, Benedetta; Ruggeri, Francesco S; Cascella, Roberta; Xu, Catherine K; Perni, Michele; Chia, Sean; Chen, Serene W; Habchi, Johnny; Bigi, Alessandra; Kreiser, Ryan P; Wright, Aidan K; Albright, J Alex; Kartanas, Tadas; Kumita, Janet R; Cremades, Nunilo; Zasloff, Michael; Cecchi, Cristina; Knowles, Tuomas P J; Chiti, Fabrizio; Vendruscolo, Michele; Dobson, Christopher M

Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease

α-突触核蛋白聚集体的多样性及其在疾病中的可能作用

Gracia, Pablo; Camino, José D; Volpicelli-Daley, Laura; Cremades, Nunilo

Correction: Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice

更正:定义导致小鼠帕金森病表型的α-突触核蛋白种类

Froula, Jessica M; Castellana-Cruz, Marta; Anabtawi, Nadia M; Camino, José D; Chen, Serene W; Thrasher, Drake R; Freire, Jennifer; Yazdi, Allen A; Fleming, Sheila; Dobson, Christopher M; Kumita, Janet R; Cremades, Nunilo; Volpicelli-Daley, Laura A

Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice

定义导致小鼠帕金森病表型的 α-突触核蛋白种类

Jessica M Froula, Marta Castellana-Cruz, Nadia M Anabtawi, José D Camino, Serene W Chen, Drake R Thrasher, Jennifer Freire, Allen A Yazdi, Sheila Fleming, Christopher M Dobson, Janet R Kumita, Nunilo Cremades, Laura A Volpicelli-Daley

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

针对 α-突触核蛋白内在无序结构集合的新型小分子可预防多种 α-突触核蛋白介导的功能障碍

Gergely Tóth, Thomas Neumann, Amandine Berthet, Eliezer Masliah, Brian Spencer, Jiahui Tao, Michael F Jobling, Shyra J Gardai, Carlos W Bertoncini, Nunilo Cremades, Michael Bova, Stephen Ballaron, Xiao-Hua Chen, Wenxian Mao, Phuong Nguyen, Mariano C Tabios, Mitali A Tambe, Jean-Christophe Rochet, Ha