Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
Trodusquemine通过一种通用机制将错误折叠的蛋白质寡聚体从细胞膜上置换下来,并消除其细胞毒性。
期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-020-01140-8
Limbocker, Ryan; Mannini, Benedetta; Ruggeri, Francesco S; Cascella, Roberta; Xu, Catherine K; Perni, Michele; Chia, Sean; Chen, Serene W; Habchi, Johnny; Bigi, Alessandra; Kreiser, Ryan P; Wright, Aidan K; Albright, J Alex; Kartanas, Tadas; Kumita, Janet R; Cremades, Nunilo; Zasloff, Michael; Cecchi, Cristina; Knowles, Tuomas P J; Chiti, Fabrizio; Vendruscolo, Michele; Dobson, Christopher M