Obdulia Rabal相关文献与解析，生知库 | 链接生命科学的每一步

Edurne San José-Enériz # ，Naroa Gimenez-Camino # ，Obdulia Rabal ，Leire Garate ，Estibaliz Miranda ，Nahia Gómez-Echarte ，Fernando García ，Stella Charalampopoulou ，Elena Sáez ，Amaia Vilas-Zornoza ，Patxi San Martín-Uriz ，Luis V Valcárcel ，Naroa Barrena ，Diego Alignani ，Luis Esteban Tamariz-Amador ，Ana Pérez-Ruiz ，Sebastian Hilscher ，Mike Schutkowski ，Ana Alfonso-Pierola ，Nicolás Martinez-Calle ，María José Larrayoz ，Bruno Paiva ，María José Calasanz ，Javier Muñoz ，Marta Isasa ，José Ignacio Martin-Subero ，Antonio Pineda-Lucena ，Julen Oyarzabal ，Xabier Agirre ，Felipe Prósper

白血病

表观遗传

发表日期：2024

文献求助收藏

Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer's Disease

利用组蛋白去乙酰化酶和磷酸二酯酶抑制剂的选择性设计更好的治疗阿尔茨海默病的治疗策略

期刊:Frontiers in Aging Neuroscience

影响因子:4.1

doi:10.3389/fnagi.2019.00149

Mar Cuadrado-Tejedor, Marta Pérez-González, Cristina García-Muñoz, Damián Muruzabal, Carolina García-Barroso, Obdulia Rabal, Víctor Segura, Juan A Sánchez-Arias, Julen Oyarzabal, Ana Garcia-Osta

Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies

发现针对血液系统恶性肿瘤中 G9a 和 DNMT 的同类首创可逆双重小分子抑制剂

期刊:Nature Communications

影响因子:14.7

doi:10.1038/ncomms15424

Edurne San José-Enériz, Xabier Agirre, Obdulia Rabal, Amaia Vilas-Zornoza, Juan A Sanchez-Arias, Estibaliz Miranda, Ana Ugarte, Sergio Roa, Bruno Paiva, Ander Estella-Hermoso de Mendoza, Rosa María Alvarez, Noelia Casares, Victor Segura, José I Martín-Subero, François-Xavier Ogi, Pierre Soule, Clara

肿瘤

发表日期：2017

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A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice

一种首创的小分子，可作为 HDAC 和 PDE5 的双重抑制剂，并能挽救阿尔茨海默病小鼠的海马突触损伤

期刊:Neuropsychopharmacology

影响因子:6.6

doi:10.1038/npp.2016.163

Mar Cuadrado-Tejedor, Carolina Garcia-Barroso, Juan A Sánchez-Arias, Obdulia Rabal, Marta Pérez-González, Sara Mederos, Ana Ugarte, Rafael Franco, Victor Segura, Gertrudis Perea, Julen Oyarzabal, Ana Garcia-Osta

Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome

针对 G9a 和 DNMT1 的可逆双重抑制剂可改善人类 iPSC 衍生，增强 MET 并促进转录因子与基因组的结合

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0190275

Juan Roberto Rodriguez-Madoz, Edurne San Jose-Eneriz, Obdulia Rabal, Natalia Zapata-Linares, Estibaliz Miranda, Saray Rodriguez, Angelo Porciuncula, Amaia Vilas-Zornoza, Leire Garate, Victor Segura, Elizabeth Guruceaga, Xabier Agirre, Julen Oyarzabal, Felipe Prosper

信号转导

发表日期：2017

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Identification of LAG3 high affinity aptamers by HT-SELEX and Conserved Motif Accumulation (CMA)

通过 HT-SELEX 和保守基序积累 (CMA) 鉴定 LAG3 高亲和力适体

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0185169

Mario Martínez Soldevilla, Sandra Hervas, Helena Villanueva, Teresa Lozano, Obdulia Rabal, Julen Oyarzabal, Juan José Lasarte, Maurizio Bendandi, Susana Inoges, Ascensión López-Díaz de Cerio, Fernando Pastor

信号转导

发表日期：2017

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Imidazo[1,2-a]pyrazines as novel PI3K inhibitors

咪唑并[1,2-a]吡嗪作为新型 PI3K 抑制剂

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.5

doi:10.1016/j.bmcl.2012.01.074

Sonia Martínez González, Ana Isabel Hernández, Carmen Varela, Sonsoles Rodríguez-Arístegui, Rosa María Alvarez, Ana Belén García, Milagros Lorenzo, Virginia Rivero, Julen Oyarzabal, Obdulia Rabal, James R Bischoff, Maribel Albarrán, Antonio Cebriá, Patricia Alfonso, Wolfgang Link, Jesús Fominaya, Jo

Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach

通过全面的面向片段的虚拟筛选方法发现丝裂原活化蛋白激酶相互作用激酶 1 抑制剂

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/jm1005513

Julen Oyarzabal, Natasha Zarich, María Isabel Albarran, Irene Palacios, Manuel Urbano-Cuadrado, Genoveva Mateos, Isabel Reymundo, Obdulia Rabal, Antonio Salgado, Ana Corrionero, Jesús Fominaya, Joaquin Pastor, James R Bischoff

信号转导

发表日期：2010

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Epigenetic-based differentiation therapy for Acute Myeloid Leukemia

基于表观遗传学的急性髓系白血病分化疗法

Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer's Disease

利用组蛋白去乙酰化酶和磷酸二酯酶抑制剂的选择性设计更好的治疗阿尔茨海默病的治疗策略

Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies

发现针对血液系统恶性肿瘤中 G9a 和 DNMT 的同类首创可逆双重小分子抑制剂

A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice

一种首创的小分子，可作为 HDAC 和 PDE5 的双重抑制剂，并能挽救阿尔茨海默病小鼠的海马突触损伤

Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome

针对 G9a 和 DNMT1 的可逆双重抑制剂可改善人类 iPSC 衍生，增强 MET 并促进转录因子与基因组的结合

Identification of LAG3 high affinity aptamers by HT-SELEX and Conserved Motif Accumulation (CMA)

通过 HT-SELEX 和保守基序积累 (CMA) 鉴定 LAG3 高亲和力适体

Imidazo[1,2-a]pyrazines as novel PI3K inhibitors

咪唑并[1,2-a]吡嗪作为新型 PI3K 抑制剂

Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach

通过全面的面向片段的虚拟筛选方法发现丝裂原活化蛋白激酶相互作用激酶 1 抑制剂