日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis

基于参考序列的化学-遗传相互作用分析阐明结核分枝杆菌中小分子的作用机制

Bond, Austin N; Orzechowski, Marek; Zhang, Shuting; Ben-Zion, Ishay; Lemmer, Allison; Garry, Nathaniel; Lee, Katie; Chen, Michael; Delano, Kayla; Gath, Emily; Golas, A Lorelei; Nietupski, Raymond; Fitzgerald, Michael; Ehrt, Sabine; Rubin, Eric J; Sassetti, Christopher M; Schnappinger, Dirk; Shoresh, Noam; Hunt, Diana K; Gomez, James E; Hung, Deborah T

Optimizing drug design by merging generative AI with a physics-based active learning framework.

将生成式人工智能与基于物理的主动学习框架相结合,优化药物设计

Filella-Merce Isaac, Molina Alexis, Díaz Lucía, Orzechowski Marek, Berchiche Yamina A, Zhu Yang Ming, Vilalta-Mor Júlia, Malo Laura, Yekkirala Ajay S, Ray Soumya, Guallar Victor

Perturbation-specific transcriptional mapping for unbiased target elucidation of antibiotics

扰动特异性转录组图谱分析用于无偏倚地阐明抗生素靶点

Romano, Keith P; Bagnall, Josephine; Warrier, Thulasi; Sullivan, Jaryd; Ferrara, Kristina; Orzechowski, Marek; Nguyen, Phuong H; Raines, Kyra; Livny, Jonathan; Shoresh, Noam; Hung, Deborah T

At-home Testing and Risk Factors for Acquisition of SARS-CoV-2 Infection in a Major US Metropolitan Area

美国某大都市区居家检测及SARS-CoV-2感染风险因素

Woolley, Ann E; Dryden-Peterson, Scott; Kim, Andy; Naz-McLean, Sarah; Kelly, Christina; Laibinis, Hannah H; Bagnall, Josephine; Livny, Jonathan; Ma, Peijun; Orzechowski, Marek; Gomez, James; Shoresh, Noam; Gabriel, Stacey; Hung, Deborah T; Cosimi, Lisa A

SARS-CoV-2 antibody persistence in COVID-19 convalescent plasma donors: Dependency on assay format and applicability to serosurveillance

SARS-CoV-2抗体在COVID-19康复期血浆捐献者中的持久性:对检测方法的依赖性及其在血清监测中的适用性

Di Germanio, Clara; Simmons, Graham; Kelly, Kathleen; Martinelli, Rachel; Darst, Orsolya; Azimpouran, Mahzad; Stone, Mars; Hazegh, Kelsey; Grebe, Eduard; Zhang, Shuting; Ma, Peijun; Orzechowski, Marek; Gomez, James E; Livny, Jonathan; Hung, Deborah T; Vassallo, Ralph; Busch, Michael P; Dumont, Larry J

HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments

HCM 和 DCM 心肌病相关的 α-原肌球蛋白突变会影响其关闭状态的稳定性以及与细肌丝的横桥相互作用。

Farman, Gerrie P; Rynkiewicz, Michael J; Orzechowski, Marek; Lehman, William; Moore, Jeffrey R

Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin

静电相互作用图谱揭示了原肌球蛋白在F-肌动蛋白上的新结合位点

Rynkiewicz, Michael J; Schott, Veronika; Orzechowski, Marek; Lehman, William; Fischer, Stefan

Three-dimensional organization of troponin on cardiac muscle thin filaments in the relaxed state

心肌细丝上肌钙蛋白在舒张状态下的三维结构

Yang, Shixin; Barbu-Tudoran, Lucian; Orzechowski, Marek; Craig, Roger; Trinick, John; White, Howard; Lehman, William

An atomic model of the tropomyosin cable on F-actin

肌动蛋白上原肌球蛋白束的原子模型

Orzechowski, Marek; Li, Xiaochuan Edward; Fischer, Stefan; Lehman, William

The structural dynamics of α-tropomyosin on F-actin shape the overlap complex between adjacent tropomyosin molecules

α-原肌球蛋白在F-肌动蛋白上的结构动力学决定了相邻原肌球蛋白分子之间的重叠复合物的形成。

Lehman, William; Li, Xiaochuan Edward; Orzechowski, Marek; Fischer, Stefan