日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Differential effects of voluntary exercise and Totum-448, a plant-based formulation, in a hamster model of MASLD

在仓鼠MASLD模型中，自愿运动和植物制剂Totum-448的不同作用

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-026-43177-5
Chavanelle, Vivien; Ennequin, Gaël; Ripoche, Doriane; Otero, Yolanda F; Joubioux, Florian Le; Maugard, Thierry; Hervieu, Valérie; Peltier, Sébastien; Sirvent, Pascal
发表日期：2026
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Small intestine is not colon: a new in vitro model of the human ileum microbiome integrating the mucosal microenvironment and feeding status

小肠并非结肠：一种整合黏膜微环境和摄食状态的新型人回肠微生物组体外模型

期刊:Gut Microbes
影响因子:11
doi:10.1080/19490976.2025.2579353
Bron, Auriane; Beltramo, Chloé; Durif, Claude; Arora, Trisha; Deschamps, Charlotte; Couturier, Ingrid; Domingo-Almenara, Xavier; Otero, Yolanda F; Denis, Sylvain; Van de Wiele, Tom; Blanquet-Diot, Stéphanie
微生物学
发表日期：2025
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TOTUM-854 Human Circulating Bioactives Preserve Endothelial Cell Function.

TOTUM-854 人类循环生物活性物质可维持内皮细胞功能

期刊:Nutrients
影响因子:5
doi:10.3390/nu17081331
Wauquier Fabien, Ripoche Doriane, Boutin-Wittrant Line, Otero Yolanda F, Krisa Stéphanie, Valls Josep, Maura Mahéva, Le Joubioux Florian, Maugard Thierry, Bolea Gaëtan, Meyer Grégory, Reboul Cyril, Roux Véronique, Macian Nicolas, Pickering Gisèle, Pereira Bruno, Bargetto Maxime, Sapone Véronique, Cazaubiel Murielle, Peltier Sébastien, Sirvent Pascal, Wittrant Yohann
细胞生物学
Human
发表日期：2025
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Bioavailable human metabolites from TOTUM-448 (plant-based formulation) maintain liver cell functionality in a hyperlipidic context that drives MASLD onset.

TOTUM-448（植物制剂）中的生物可利用的人体代谢物在高脂环境下维持肝细胞功能，从而防止 MASLD 的发生。

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-32556-z
Wauquier Fabien, Chavanelle Vivien, Bouchard-Mercier Annie, Boutin-Wittrant Line, Otero Yolanda F, Krisa Stéphanie, Valls Josep, Le Joubioux Florian, Pereira Bruno, Roux Véronique, Macian Nicolas, Pickering Gisèle, Sapone Véronique, Cazaubiel Murielle, Bron Auriane, Peltier Sébastien, Blanquet Stéphanie, Sirvent Pascal, Wittrant Yohann
Human
细胞生物学
Mas
发表日期：2025
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Totum-448 Improves MASLD and Modulates Microbiota in Hamsters: Dose-Response Study and Effects of Supplementation Cessation.

Totum-448 改善 MASLD 并调节仓鼠的微生物群：剂量反应研究和停止补充的影响

期刊:Food Science & Nutrition
影响因子:3.8
doi:10.1002/fsn3.70904
Chavanelle Vivien, Vallier Marie, Otero Yolanda F, Ripoche Doriane, Le Joubioux Florian, Maugard Thierry, Ennequin Gaël, Hervieu Valérie, Peltier Sébastien, Sirvent Pascal
微生物学
发表日期：2025
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Inhibitory Potential of α-Amylase, α-Glucosidase, and Pancreatic Lipase by a Formulation of Five Plant Extracts: TOTUM-63

五种植物提取物制剂对α-淀粉酶、α-葡萄糖苷酶和胰脂肪酶的抑制潜力：TOTUM-63

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms24043652
Haguet, Quentin; Le Joubioux, Florian; Chavanelle, Vivien; Groult, Hugo; Schoonjans, Nathan; Langhi, Cédric; Michaux, Arnaud; Otero, Yolanda F; Boisseau, Nathalie; Peltier, Sébastien L; Sirvent, Pascal; Maugard, Thierry
发表日期：2023
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TOTUM-63, a plant-based polyphenol-rich extract, improves glycaemic control in subjects with prediabetes or early stage newly-diagnosed type 2 diabetes in a randomized, double-blind, placebo-controlled trial

在一项随机、双盲、安慰剂对照试验中，富含多酚的植物提取物 TOTUM-63 可改善糖尿病前期或早期新诊断的 2 型糖尿病患者的血糖控制。

期刊:Diabetes Obesity & Metabolism
影响因子:5.7
doi:10.1111/dom.14817
Sirvent, Pascal; Chavanelle, Vivien; Otero, Yolanda F; Bargetto, Maxime; Le Joubioux, Florian; Boisseau, Nathalie; Maugard, Thierry; Cazaubiel, Murielle; Pereira, Bruno; Guigas, Bruno; Hadjadj, Samy; Peltier, Sebastien L; Marette, André; Bard, Jean-Marie
糖尿病
代谢
发表日期：2022
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Effects of Totum-63 on glucose homeostasis and postprandial glycemia: a translational study.

Totum-63 对葡萄糖稳态和餐后血糖的影响：一项转化研究

期刊:American Journal of Physiology-Endocrinology and Metabolism
影响因子:3.1
doi:10.1152/ajpendo.00629.2020
Chavanelle Vivien, Otero Yolanda F, Le Joubioux Florian, Ripoche Doriane, Bargetto Maxime, Vluggens Aurore, Montaurier Christophe, Pickering Gisèle, Ducheix Gilles, Dubray Claude, Dualé Christian, Boulliau Sylvia, Macian Nicolas, Marceau Geoffroy, Sapin Vincent, Dutheil Frédéric, Guigas Bruno, Maugard Thierry, Boisseau Nathalie, Cazaubiel Murielle, Peltier Sébastien L, Sirvent Pascal
发表日期：2021
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Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process

油酸对心血管胰岛素抵抗以及早期和晚期细胞动脉粥样硬化过程的保护作用

期刊:Cardiovascular Diabetology
影响因子:10.6
doi:10.1186/s12933-015-0237-9
Perdomo, Liliana; Beneit, Nuria; Otero, Yolanda F; Escribano, Óscar; Díaz-Castroverde, Sabela; Gómez-Hernández, Almudena; Benito, Manuel
心血管
代谢
细胞生物学
动脉粥样硬化
免疫/内分泌
发表日期：2015
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Tissue inflammation and nitric oxide-mediated alterations in cardiovascular function are major determinants of endotoxin-induced insulin resistance

组织炎症和一氧化氮介导的心血管功能改变是内毒素诱导胰岛素抵抗的主要决定因素。

期刊:Cardiovascular Diabetology
影响因子:10.6
doi:10.1186/s12933-015-0223-2
House, Lawrence M 2nd; Morris, Robert T; Barnes, Tammy M; Lantier, Louise; Cyphert, Travis J; McGuinness, Owen P; Otero, Yolanda F
炎症/感染
代谢
炎症
免疫/内分泌
发表日期：2015
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