日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Enhanced HDR-mediated correction of heterozygous COL7A1 mutations for recessive dystrophic epidermolysis bullosa

增强 HDR 介导的隐性营养不良性大疱性表皮松解症杂合 COL7A1 突变的校正

Hunt, John M T; du Rand, Alex; Verdon, Daniel; Clemance, Leah; Loef, Evert; Malhi, Chloe; Buttle, Ben; Knapp, David J H F; Michaels, Yale S; Garlick, Jonathan; Dunbar, P Rod; Purvis, Diana; Feisst, Vaughan; Sheppard, Hilary

A novel approach to digital characterisation of Tertiary Lymphoid Structures in colorectal cancer

一种用于结直肠癌三级淋巴结构数字化表征的新方法

Luis Munoz-Erazo # ,Saem Mul Park # ,Shelly Lin ,Chun-Jen J Chen ,Lisa Y Y Zhou ,Janet L Rhodes ,Taesung Jeon ,Sonya Fenton ,John L McCall ,Roslyn A Kemp ,P Rod Dunbar

Efficient Dual Cas9 Nickase Correction of a Prevalent Pathogenic LAMB 3 Variant for Junctional Epidermolysis Bullosa.

高效双 Cas9 切口酶校正常见致病性 LAMB 3 变体,用于治疗交界性大疱性表皮松解症

du Rand Alex, Hunt John, Verdon Daniel, Buttle Ben, Dunbar P Rod, Purvis Diana, Feisst Vaughan, Sheppard Hilary

Oral PD-L1 inhibitor GS-4224 selectively engages PD-L1 high cells and elicits pharmacodynamic responses in patients with advanced solid tumors

口服PD-L1抑制剂GS-4224选择性地与PD-L1高表达细胞结合,并在晚期实体瘤患者中引发药效学反应。

Odegard, Jared M; Othman, Ahmed A; Lin, Kai-Wen; Wang, Adele Y; Nazareno, Jonathan; Yoon, Oh Kyu; Ling, John; Lad, Latesh; Dunbar, P Rod; Thai, Dung; Ang, Edmond; Waldron, Nicholas; Deva, Sanjeev

Safety, pharmacodynamics, and antiviral activity of selgantolimod in viremic patients with chronic hepatitis B virus infection

selgantolimod 在伴有慢性乙型肝炎病毒感染的病毒血症患者中的安全性、药效学和抗病毒活性

Janssen, Harry L; Lim, Young-Suk; Kim, Hyung Joon; Sowah, Leonard; Tseng, Cheng-Hao; Coffin, Carla S; Elkhashab, Magdy; Ahn, Sang Hoon; Nguyen, Anh-Hoa; Chen, Diana; Wallin, Jeffrey J; Fletcher, Simon P; McDonald, Circe; Yang, Jenny C; Gaggar, Anuj; Brainard, Diana M; Fung, Scott; Kim, Yoon Jun; Kao, Jia-Horng; Chuang, Wan-Long; Brooks, Anna E; Dunbar, P Rod

Proliferating macrophages in human tumours show characteristics of monocytes responding to myelopoietic growth factors

人类肿瘤中增殖的巨噬细胞表现出对骨髓生成生长因子有反应的单核细胞的特征。

Park, Saem Mul; Chen, Chun-Jen J; Verdon, Daniel J; Ooi, Marcus P Y; Brooks, Anna E S; Martin, Richard C W; Mathy, Jon A; Emanuel, Patrick O; Dunbar, P Rod

Plasminogen and plasmin can bind to human T cells and generate truncated CCL21 that increases dendritic cell chemotactic responses

纤溶酶原和纤溶酶可与人T细胞结合,产生截短的CCL21,从而增强树突状细胞的趋化反应。

Evert J Loef ,Hilary M Sheppard ,Nigel P Birch ,P Rod Dunbar

Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effect

NKT 细胞激动剂与 CpG 的肿瘤内给药可促进 NKT 细胞浸润,从而增强抗肿瘤反应和远隔效应

Kef K Prasit, Laura Ferrer-Font, Olivia K Burn, Regan J Anderson, Benjamin J Compton, Alfonso J Schmidt, Johannes U Mayer, Chun-Jen J Chen, Nathaniel Dasyam, David S Ritchie, Dale I Godfrey, Stephen R Mattarollo, P Rod Dundar, Gavin F Painter, Ian F Hermans

Live-Cell Microscopy Reveals That Human T Cells Primarily Respond Chemokinetically Within a CCL19 Gradient That Induces Chemotaxis in Dendritic Cells

活细胞显微镜显示,人类T细胞主要在CCL19梯度内进行趋化动力学反应,而CCL19梯度可诱导树突状细胞趋化性。

Evert J Loef ,Hilary M Sheppard ,Nigel P Birch ,P Rod Dunbar

Results of a randomized, double-blind phase II clinical trial of NY-ESO-1 vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in participants with high-risk resected melanoma

一项随机、双盲 II 期临床试验的结果显示,在接受切除手术的高危黑色素瘤患者中,NY-ESO-1 疫苗联合 ISCOMATRIX 佐剂与单独使用 ISCOMATRIX 佐剂的疗效存在差异。

Cebon, Jonathan S; Gore, Martin; Thompson, John F; Davis, Ian D; McArthur, Grant A; Walpole, Euan; Smithers, Mark; Cerundolo, Vincenzo; Dunbar, P Rod; MacGregor, Duncan; Fisher, Cyril; Millward, Michael; Nathan, Paul; Findlay, Michael P N; Hersey, Peter; Evans, T R Jeffry; Ottensmeier, Christian Hermann; Marsden, Jeremy; Dalgleish, Angus G; Corrie, Pippa G; Maria, Marples; Brimble, Margaret; Williams, Geoff; Winkler, Sintia; Jackson, Heather M; Endo-Munoz, Liliana; Tutuka, Candani S A; Venhaus, Ralph; Old, Lloyd J; Haack, Dennis; Maraskovsky, Eugene; Behren, Andreas; Chen, Weisan