日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular basis for anti-jumbo phage immunity by AVAST type 5

AVAST 5型抗巨型噬菌体免疫的分子基础

Muralidharan, Aswin; Costa, Ana Rita; Fierlier, Desi; van den Berg, Daan Frits; van den Bossche, Halewijn; Zoumaro-Djayoon, Adja Damba; Rodríguez-Molina, Alicia; Pabst, Martin; Pacesa, Martin; Correia, Bruno E; Brouns, Stan J J

Targeting protein-ligand neosurfaces with a generalizable deep learning tool

使用可通用的深度学习工具靶向蛋白质-配体新表面

Anthony Marchand #, Stephen Buckley #, Arne Schneuing #, Martin Pacesa, Maddalena Elia, Pablo Gainza, Evgenia Elizarova, Rebecca M Neeser, Pao-Wan Lee, Luc Reymond, Yangyang Miao, Leo Scheller, Sandrine Georgeon, Joseph Schmidt, Philippe Schwaller, Sebastian J Maerkl, Michael Bronstein, Bruno E Corr

One-shot design of functional protein binders with BindCraft

利用 BindCraft 一次性设计功能性蛋白质结合剂

Martin Pacesa # ,Lennart Nickel # ,Christian Schellhaas # ,Joseph Schmidt ,Ekaterina Pyatova ,Lucas Kissling ,Patrick Barendse ,Jagrity Choudhury ,Srajan Kapoor ,Ana Alcaraz-Serna ,Yehlin Cho ,Kourosh H Ghamary ,Laura Vinué ,Brahm J Yachnin ,Andrew M Wollacott ,Stephen Buckley ,Adrie H Westphal ,Simon Lindhoud ,Sandrine Georgeon ,Casper A Goverde ,Georgios N Hatzopoulos ,Pierre Gönczy ,Yannick D Muller ,Gerald Schwank ,Daan C Swarts ,Alex J Vecchio ,Bernard L Schneider ,Sergey Ovchinnikov ,Bruno E Correia

Custom CRISPR-Cas9 PAM variants via scalable engineering and machine learning

通过可扩展的工程和机器学习技术构建定制的 CRISPR-Cas9 PAM 变体

Silverstein, Rachel A; Kim, Nahye; Kroell, Ann-Sophie; Walton, Russell T; Delano, Justin; Butcher, Rossano M; Pacesa, Martin; Smith, Blaire K; Christie, Kathleen A; Ha, Leillani L; Meis, Ronald J; Clark, Aaron B; Spinner, Aviv D; Lazzarotto, Cicera R; Li, Yichao; Matsubara, Azusa; Urbina, Elizabeth O; Dahl, Gary A; Correia, Bruno E; Marks, Debora S; Tsai, Shengdar Q; Pinello, Luca; De Ravin, Suk See; Liu, Qin; Kleinstiver, Benjamin P

Design of highly functional genome editors by modelling CRISPR-Cas sequences

通过对 CRISPR-Cas 序列进行建模来设计高功能基因组编辑器

Ruffolo, Jeffrey A; Nayfach, Stephen; Gallagher, Joseph; Bhatnagar, Aadyot; Beazer, Joel; Hussain, Riffat; Russ, Jordan; Yip, Jennifer; Hill, Emily; Pacesa, Martin; Meeske, Alexander J; Cameron, Peter; Madani, Ali

Structures of a synthetic antibody selected against and bound to the C-terminal domain of Clostridium perfringens enterotoxin

针对产气荚膜梭菌肠毒素C端结构域筛选并结合的合成抗体的结构

Ogbu, Chinemerem P; Goldbach, Nicolas Manuel; Pacesa, Martin; Kapoor, Srajan; Correia, Bruno E; Vecchio, Alex J

Computational design of soluble and functional membrane protein analogues

可溶性和功能性膜蛋白类似物的计算设计

Casper A Goverde #, Martin Pacesa #, Nicolas Goldbach #, Lars J Dornfeld, Petra E M Balbi, Sandrine Georgeon, Stéphane Rosset, Srajan Kapoor, Jagrity Choudhury, Justas Dauparas, Christian Schellhaas, Simon Kozlov, David Baker, Sergey Ovchinnikov, Alex J Vecchio, Bruno E Correia

De novo design of protein interactions with learned surface fingerprints

利用学习到的表面指纹从头设计蛋白质相互作用

Pablo Gainza #, Sarah Wehrle #, Alexandra Van Hall-Beauvais #, Anthony Marchand #, Andreas Scheck #, Zander Harteveld, Stephen Buckley, Dongchun Ni, Shuguang Tan, Freyr Sverrisson, Casper Goverde, Priscilla Turelli, Charlène Raclot, Alexandra Teslenko, Martin Pacesa, Stéphane Rosset, Sandrine George

PAM-flexible genome editing with an engineered chimeric Cas9

利用工程嵌合 Cas9 进行 PAM 灵活的基因组编辑

Lin Zhao, Sabrina R T Koseki, Rachel A Silverstein, Nadia Amrani, Christina Peng, Christian Kramme, Natasha Savic, Martin Pacesa, Tomás C Rodríguez, Teodora Stan, Emma Tysinger, Lauren Hong, Vivian Yudistyra, Manvitha R Ponnapati, Joseph M Jacobson, George M Church, Noah Jakimo, Ray Truant, Martin J

PAM-Flexible Genome Editing with an Engineered Chimeric Cas9

利用工程嵌合 Cas9 进行 PAM 灵活基因组编辑

Sabrina Koseki, Lauren Hong, Vivian Yudistyra, Teodora Stan, Emma Tysinger, Rachel Silverstein, Christian Kramme, Nadia Amrani, Natasha Savic, Martin Pacesa, Tomás Rodriguez, Manvitha Ponnapati, Joseph Jacobson, George Church, Ray Truant, Martin Jinek, Benjamin Kleinstiver, Erik Sontheimer, Pranam C