Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.
FK506 对钙调磷酸酶的抑制作用通过增加 S421 位点亨廷顿蛋白的磷酸化来防止多聚谷氨酰胺亨廷顿蛋白的毒性
期刊:Journal of Neuroscience
影响因子:4
doi:10.1523/JNEUROSCI.3706-05.2006
Pardo Raúl, Colin Emilie, Régulier Etienne, Aebischer Patrick, Déglon Nicole, Humbert Sandrine, Saudou Frédéric
