日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Heparan sulfate fine-tuned interleukin-1 (IL-1) signaling inhibits insulin secretion of grafted pancreatic islets

硫酸乙酰肝素通过精细调节白细胞介素-1 (IL-1) 信号通路抑制移植胰岛的胰岛素分泌。

Selina Wrublewsky ,Sandra Rother ,Franziska Pohlemann ,Toni Radanovic ,Fabian Junker ,Anne S Boewe ,Stefan Schunk ,Leticia P Roma ,Gloria Ruiz-Gómez ,M Teresa Pisabarro ,Patrick E MacDonald ,Michael D Menger ,Matthias W Laschke ,Emmanuel Ampofo

Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice

热量限制可增加胰岛素敏感性,促进小鼠β细胞稳态和寿命

Cristiane Dos Santos #, Amanda Cambraia #, Shristi Shrestha, Melanie Cutler, Matthew Cottam, Guy Perkins, Varda Lev-Ram, Birbickram Roy, Christopher Acree, Keun-Young Kim, Thomas Deerinck, Danielle Dean, Jean Philippe Cartailler, Patrick E MacDonald, Martin Hetzer, Mark Ellisman, Rafael Arrojo E Dri

A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding

SENP1 氧化还原感应在 β 细胞对高脂饮食反应中的作用和机制

Haopeng Lin #, Kunimasa Suzuki #, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes, Aliya F Spigelman, Xiao-Qing Dai, Austin Bautista, Mourad Ferdaoussi, Saloni Aggarwal, Andrew R Pepper, Leticia P Roma, Emmanuel Ampofo, Wen-Hong Li, Patrick E MacDonald

CK2 activity is crucial for proper glucagon expression

CK2活性对于胰高血糖素的正常表达至关重要

Emmanuel Ampofo # ,Mandy Pack # ,Selina Wrublewsky # ,Anne S Boewe ,Aliya F Spigelman ,Hanna Koch ,Patrick E MacDonald ,Matthias W Laschke ,Mathias Montenarh ,Claudia Götz

An INSULIN and IAPP dual reporter enables tracking of functional maturation of stem cell-derived insulin producing cells

INSULIN 和 IAPP 双重报告基因能够追踪干细胞衍生的胰岛素生成细胞的功能成熟

Carmen L Bayly, Xiao-Qing Dai, Cuilan Nian, Paul C Orban, C Bruce Verchere, Patrick E MacDonald, Francis C Lynn

TMEM55A-mediated PI5P signaling regulates α-cell actin depolymerization and glucagon secretion

TMEM55A 介导的 PI5P 信号调节 α 细胞肌动蛋白解聚和胰高血糖素分泌

Xiong Liu, Theodore Dos Santos, Aliya F Spigelman, Shawn Duckett, Nancy Smith, Kunimasa Suzuki, Patrick E MacDonald

Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk

胰岛单细胞多组学分析揭示与糖尿病风险相关的细胞类型特异性调节的生理变化

Hannah M Mummey, Weston Elison, Katha Korgaonkar, Ruth M Elgamal, Parul Kudtarkar, Emily Griffin, Paola Benaglio, Michael Miller, Alokkumar Jha, Jocelyn E Manning Fox, Mark I McCarthy, Sebastian Preissl, Anna L Gloyn, Patrick E MacDonald, Kyle J Gaulton

Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes

将遗传学与不同疾病状态下的单细胞多组学测量相结合,可确定 2 型糖尿病中 β 细胞功能障碍的机制

Gaowei Wang #, Joshua Chiou #, Chun Zeng #, Michael Miller, Ileana Matta, Jee Yun Han, Nikita Kadakia, Mei-Lin Okino, Elisha Beebe, Medhavi Mallick, Joan Camunas-Soler, Theodore Dos Santos, Xiao-Qing Dai, Cara Ellis, Yan Hang, Seung K Kim, Patrick E MacDonald, Fouad R Kandeel, Sebastian Preissl, Kyl

Modulation of insulin secretion by RBFOX2-mediated alternative splicing

RBFOX2介导的选择性剪接对胰岛素分泌的调节

Nicole D Moss ,Kristen L Wells ,Alexandra Theis ,Yong-Kyung Kim ,Aliya F Spigelman ,Xiong Liu ,Patrick E MacDonald ,Lori Sussel

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

胰岛β细胞中RREB1的缺失会降低细胞内胰岛素含量并影响内分泌细胞基因表达。

Katia K Mattis,Nicole A J Krentz,Christoph Metzendorf,Fernando Abaitua,Aliya F Spigelman,Han Sun,Jennifer M Ikle,Swaraj Thaman,Antje K Rottner,Austin Bautista,Eugenia Mazzaferro,Marta Perez-Alcantara,Jocelyn E Manning Fox,Jason M Torres,Agata Wesolowska-Andersen,Grace Z Yu,Anubha Mahajan,Anders Larsson,Patrick E MacDonald,Benjamin Davies,Marcel den Hoed,Anna L Gloyn