日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Phase I Study of Pelabresib (CPI-0610), a Small-Molecule Inhibitor of BET Proteins, in Patients with Relapsed or Refractory Lymphoma

Pelabresib (CPI-0610)(一种 BET 蛋白的小分子抑制剂)在复发或难治性淋巴瘤患者中的 I 期研究

Kristie A Blum, Jeffrey G Supko, Michael B Maris, Ian W Flinn, Andre Goy, Anas Younes, Suresh Bobba, Adrian M Senderowicz, Sergey Efuni, Ronda Rippley, Gozde Colak, Patrick Trojer, Jeremy S Abramson

Screening for Small-Molecule Inhibitors of Histone Methyltransferases

组蛋白甲基转移酶小分子抑制剂的筛选

Nico Cantone, Richard T Cummings, Patrick Trojer

Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis

默克尔细胞多瘤病毒激活 LSD1 介导的非经典 BAF 阻断来调节转化和肿瘤发生

Donglim Esther Park, Jingwei Cheng, John P McGrath, Matthew Y Lim, Camille Cushman, Selene K Swanson, Michelle L Tillgren, Joao A Paulo, Prafulla C Gokhale, Laurence Florens, Michael P Washburn, Patrick Trojer, James A DeCaprio

A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine

KDM5 抑制剂可增加整体 H3K4 三甲基化占有率并增强 5-氮杂-2'-脱氧胞苷的生物学功效

Benjamin R Leadem, Ioannis Kagiampakis, Catherine Wilson, Tommy K Cheung, David Arnott, Patrick Trojer, Marie Classon, Hariharan Easwaran, Stephen B Baylin

Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes

组蛋白赖氨酸去甲基化酶 KDM1A 的药理抑制可抑制多种急性髓系白血病亚型的生长

John P McGrath, Kaylyn E Williamson, Srividya Balasubramanian, Shobu Odate, Shilpi Arora, Charlie Hatton, Thomas M Edwards, Thomas O'Brien, Steven Magnuson, David Stokoe, Danette L Daniels, Barbara M Bryant, Patrick Trojer

An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition

ChIP-Seq 标准化的替代方法可以检测 EZH2 抑制后组蛋白 H3 赖氨酸 27 三甲基化的全基因组变化

Brian Egan, Chih-Chi Yuan, Madeleine Lisa Craske, Paul Labhart, Gulfem D Guler, David Arnott, Tobias M Maile, Jennifer Busby, Chisato Henry, Theresa K Kelly, Charles A Tindell, Suchit Jhunjhunwala, Feng Zhao, Charlie Hatton, Barbara M Bryant, Marie Classon, Patrick Trojer

A novel motif in fungal class 1 histone deacetylases is essential for growth and development of Aspergillus

真菌 1 类组蛋白去乙酰化酶中的一种新基序对曲霉菌的生长和发育至关重要

Martin Tribus, Ingo Bauer, Johannes Galehr, Gudrun Rieser, Patrick Trojer, Gerald Brosch, Peter Loidl, Hubertus Haas, Stefan Graessle

The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate

NSD 家族组蛋白赖氨酸甲基转移酶的靶标取决于底物的性质

Yan Li, Patrick Trojer, Chong-Feng Xu, Peggie Cheung, Alex Kuo, William J Drury 3rd, Qi Qiao, Thomas A Neubert, Rui-Ming Xu, Or Gozani, Danny Reinberg

HdaA, a major class 2 histone deacetylase of Aspergillus nidulans, affects growth under conditions of oxidative stress

HdaA 是构巢曲霉的主要 2 类组蛋白去乙酰化酶,在氧化应激条件下影响生长

Martin Tribus, Johannes Galehr, Patrick Trojer, Gerald Brosch, Peter Loidl, Florentine Marx, Hubertus Haas, Stefan Graessle