日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Novel Bruton's Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy

发现具有增强选择性和细胞功效的新型布鲁顿酪氨酸激酶 PROTAC

Yi-Qian Li, William G Lannigan, Shabnam Davoodi, Fereidoon Daryaee, Ana Corrionero, Patricia Alfonso, Jose A Rodriguez-Santamaria, Nan Wang, John D Haley, Peter J Tonge

Synthesis and Preclinical Evaluation of a Novel Fluorine-18-Labeled Tracer for Positron Emission Tomography Imaging of Bruton's Tyrosine Kinase

新型氟-18 标记示踪剂的合成及临床前评估,用于布鲁顿酪氨酸激酶的正电子发射断层扫描成像

Kaixuan Li, Mingqian Wang, Melike Akoglu, Alyssa C Pollard, John B Klecker, Patricia Alfonso, Ana Corrionero, Niall Prendiville, Wenchao Qu, Matthew F L Parker, Nashaat Turkman, Jules A Cohen, Peter J Tonge

Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity

乙酰辅酶A羧化酶异二价抑制剂:药物靶点停留时间和时间依赖性抗菌活性

Matthew T Cifone ,YongLe He ,Rajeswari Basu ,Nan Wang ,Shabnam Davoodi ,Lauren A Spagnuolo ,Yuanyuan Si ,Taraneh Daryaee ,Craig E Stivala ,Stephen G Walker ,Peter J Tonge

Impact of Target Turnover on the Translation of Drug-Target Residence Time to Time-Dependent Antibacterial Activity

靶标周转对药物靶标停留时间转化为时间依赖性抗菌活性的影响

Rajeswari Basu, Nan Wang, Sneha Basak, Fereidoon Daryaee, Mustufa Babar, Eleanor K Allen, Stephen G Walker, John D Haley, Peter J Tonge

Structural Basis for the Regulation of Biofilm Formation and Iron Uptake in A. baumannii by the Blue-Light-Using Photoreceptor, BlsA

蓝光光感受器 BlsA 调节鲍曼不动杆菌生物膜形成和铁吸收的结构基础

Iva Chitrakar, James N Iuliano, YongLe He, Helena A Woroniecka, Jinnette Tolentino Collado, Jinelle M Wint, Stephen G Walker, Peter J Tonge, Jarrod B French

Functional dynamics of a single tryptophan residue in a BLUF protein revealed by fluorescence spectroscopy

荧光光谱揭示 BLUF 蛋白中单个色氨酸残基的功能动力学

Kristof Karadi, Sofia M Kapetanaki, Katalin Raics, Ildiko Pecsi, Robert Kapronczai, Zsuzsanna Fekete, James N Iuliano, Jinnette Tolentino Collado, Agnieszka A Gil, Jozsef Orban, Miklos Nyitrai, Greg M Greetham, Marten H Vos, Peter J Tonge, Stephen R Meech, Andras Lukacs

Quantifying the Interactions between Biomolecules: Guidelines for Assay Design and Data Analysis

量化生物分子之间的相互作用:检测设计和数据分析指南

Peter J Tonge

Photoactivation of the BLUF Protein PixD Probed by the Site-Specific Incorporation of Fluorotyrosine Residues

通过位点特异性掺入氟酪氨酸残基探测 BLUF 蛋白 PixD 的光活化作用

Agnieszka A Gil, Sergey P Laptenok, James N Iuliano, Andras Lukacs, Anil Verma, Christopher R Hall, Grace E Yoon, Richard Brust, Gregory M Greetham, Michael Towrie, Jarrod B French, Stephen R Meech, Peter J Tonge

A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy

定量机制 PK/PD 模型直接将 Btk 靶向作用与体内疗效联系起来

Fereidoon Daryaee, Zhuo Zhang, Kayla R Gogarty, Yong Li, Jonathan Merino, Stewart L Fisher, Peter J Tonge

Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase

抑制类鼻疽伯克霍尔德菌 FabI1 烯酰-ACP 还原酶的结合动力学合理化

Carla Neckles, Sandra Eltschkner, Jason E Cummings, Maria Hirschbeck, Fereidoon Daryaee, Gopal R Bommineni, Zhuo Zhang, Lauren Spagnuolo, Weixuan Yu, Shabnam Davoodi, Richard A Slayden, Caroline Kisker, Peter J Tonge