日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment

KRASG12R突变型胰腺癌具有ERK/MAPK转录活性受限和独特的肿瘤微环境。

Burge, Rachel A; Le Roux, Ozgun; Popow, Olesja; Spadafora, Victoria K; Rajesh, Christabelle; Adair, Sara J; Bialousow, Lucas; Murphy, Cailey; Saberi, Samaneh; Vaena, Silvia G; Taquey, Margaret C; Allen, Sarah; Han, Lu; Helke, Kristi L; Sharma, Sudarshana; Ostrowski, Michael C; Guttridge, Denis C; Dincman, Toros A; Bauer, Todd W; Kashatus, David F; McFall, Thomas; Haigis, Kevin M; Hollingsworth, Michael A; Counter, Christopher M; Der, Channing J; Hobbs, G Aaron

Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-Driven Cancers

Zongertinib (BI 1810631) 是一种不可逆的 HER2 TKI,可抑制 EGFR 信号传导并改善临床前模型和 HER2 驱动癌症患者的治疗反应

Birgit Wilding, Lydia Woelflingseder, Anke Baum, Krzysztof Chylinski, Gintautas Vainorius, Neil Gibson, Irene C Waizenegger, Daniel Gerlach, Martin Augsten, Fiona Spreitzer, Yukina Shirai, Masachika Ikegami, Sylvia Tilandyová, Dirk Scharn, Mark A Pearson, Johannes Popow, Anna C Obenauf, Noboru Yamam

Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-Loaded KRAS(On) Alleles

鉴定一种高度协同的PROTAC降解酶,该酶靶向GTP结合的KRAS(On)等位基因

Vetma, Vesna; Puoti, Ilaria; Karolak, Natalia K; Chakraborti, Sohini; Diers, Emelyne; Girardi, Enrico; Khan, Shakil; Kidd, Giorgia; Kropatsch, Katrin G; Mclennan, Ross; O'Connor, Suzanne; Samwer, Matthias; Trainor, Nicole; Whitworth, Claire; Wijaya, Andre J; Wong, Jeff Y F; Zollman, David; Farnaby, William; Popow, Johannes; Ciulli, Alessio; Ettmayer, Peter; McAulay, Kirsten

Combining BET inhibition with SMAC mimetics restricts tumor growth and triggers immune surveillance in preclinical cancer models

在临床前癌症模型中,BET抑制剂与SMAC模拟物联合使用可抑制肿瘤生长并触发免疫监视。

Ksenija Slavic Obradovic ,Florian Ebner ,Artem V Artemov ,Martina Miotto ,Paula-Elena Traexler ,Robin Jacob ,Ha Pham Thi Thanh ,Regina Ruzicka ,Andreas Wernitznig ,Ines Baumann ,Daniel Gerlach ,Maria-Antonietta Impagnatiello ,Salvatore Siena ,Mary Murphy ,Reniqua House ,Ulrich Reiser ,Valeria Santoro ,Johannes Popow ,Sebastian Carotta ,Anke Baum ,Jesse Lipp ,Alberto Bardelli ,Ulrike Tontsch-Grunt ,Mariangela Russo ,Martin Aichinger

Pan-KRAS Inhibitors BI-2493 and BI-2865 Display Potent Antitumor Activity in Tumors with KRAS Wild-type Allele Amplification

泛KRAS抑制剂BI-2493和BI-2865在KRAS野生型等位基因扩增的肿瘤中显示出强大的抗肿瘤活性

Antonio Tedeschi # ,Fiorella Schischlik # ,Francesca Rocchetti # ,Johannes Popow ,Florian Ebner ,Daniel Gerlach ,Antonia Geyer ,Valeria Santoro ,Andrew S Boghossian ,Matthew G Rees ,Melissa M Ronan ,Jennifer A Roth ,Jesse Lipp ,Matthias Samwer ,Michael Gmachl ,Norbert Kraut ,Mark Pearson ,Dorothea Rudolph

A case of high-grade prostate cancer with low PSA levels

一例PSA水平较低的高级别前列腺癌病例

Bociański, Jan; Sklinda, Katarzyna; Walecki, Jerzy; Rogowski, Wojciech; Małek, Michał; Kasprowicz, Marek; Michałowski, Łukasz; Popow, Weronika

Baseline expression of c-Myc defines the tissue specificity of oncogenic K-Ras

c-Myc 的基础表达决定了致癌 K-Ras 的组织特异性

Popow, Olesja; Yu, Qing; Yapp, Clarance; Hull, Shannon; Paulo, João A; Hanna, Benjamin; Xu, Shidong; Kuang, Yanan; Sigel, Carlie; Paweletz, Cloud P; Gygi, Steven P; Haigis, Kevin M

Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers

表观遗传和致癌抑制剂协同驱动分化并杀死 KRAS 突变型结直肠癌

Patrick Loi #, Amy E Schade #, Carrie L Rodriguez, Anjana Krishnan, Naiara Perurena, Van T M Nguyen, Yilin Xu, Marina Watanabe, Rachel A Davis, Alycia Gardner, Natalie F Pilla, Kaia Mattioli, Olesja Popow, Nuray Gunduz, Tamsin R M Lannagan, Samantha Fitzgerald, Ewa T Sicinska, Jia-Ren Lin, William T

Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

泛 KRAS 抑制剂可抑制致癌信号传导和肿瘤生长

Dongsung Kim #, Lorenz Herdeis #, Dorothea Rudolph #, Yulei Zhao, Jark Böttcher, Alberto Vides, Carlos I Ayala-Santos, Yasin Pourfarjam, Antonio Cuevas-Navarro, Jenny Y Xue, Andreas Mantoulidis, Joachim Bröker, Tobias Wunberg, Otmar Schaaf, Johannes Popow, Bernhard Wolkerstorfer, Katrin Gabriele Kro

Regulation of GTPase function by autophosphorylation

通过自身磷酸化调节GTP酶功能

Christian W Johnson ,Hyuk-Soo Seo ,Elizabeth M Terrell ,Moon-Hee Yang ,Fenneke KleinJan ,Teklab Gebregiworgis ,Genevieve M C Gasmi-Seabrook ,Ezekiel A Geffken ,Jimit Lakhani ,Kijun Song ,Puspalata Bashyal ,Olesja Popow ,Joao A Paulo ,Andrea Liu ,Carla Mattos ,Christopher B Marshall ,Mitsuhiko Ikura ,Deborah K Morrison ,Sirano Dhe-Paganon ,Kevin M Haigis