Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation
具有不寻常的 N-三氟甲基吡唑药效团且对代谢 N-脱烷基化具有抗性的新型强效 CHK1 激酶选择性抑制剂的合成与分析
期刊:Molecular Cancer Therapeutics
影响因子:5.3
doi:10.1158/1535-7163.MCT-17-0018
Pounami Samadder, Tereza Suchánková, Ondřej Hylse, Prashant Khirsariya, Fedor Nikulenkov, Stanislav Drápela, Nicol Straková, Petr Vaňhara, Kateřina Vašíčková, Hana Kolářová, Lucia Binó, Miroslava Bittová, Petra Ovesná, Peter Kollár, Radek Fedr, Milan Ešner, Josef Jaroš, Aleš Hampl, Lumír Krejčí, Kam
