日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling.

抑制去泛素化酶活性和炎症信号的分子胶

Chandler Francesca, Reddy Poli Adi Narayana, Bhutda Smita, Ross Rebecca L, Datta Arindam, Walden Miriam, Walker Kieran, Di Donato Stefano, Cassel Joel A, Prakesch Michael A, Aman Ahmed, Datti Alessandro, Campbell Lisa J, Foglizzo Martina, Bell Lillie, Stein Daniel N, Ault James R, Al-Awar Rima S, Calabrese Antonio N, Sicheri Frank, Del Galdo Francesco, Salvino Joseph M, Greenberg Roger A, Zeqiraj Elton

A kinome drug screen identifies multi-TKI synergies and ERBB2 signaling as a therapeutic vulnerability in MYC/TYR subgroup atypical teratoid rhabdoid tumors.

激酶组药物筛选发现多 TKI 协同作用和 ERBB2 信号传导是 MYC/TYR 亚组非典型畸胎瘤样横纹肌瘤的治疗弱点

Golbourn Brian, Ho Ben, Bondoc Andrew, Luck Amanda, Fan Xiaolian, Richardson Elizabeth, Marcellus Richard, Prakesch Michael, Halbert Mathew, Agrawal Nishant, Smith Christian, Huang Annie, Rutka James T

Molecular glues that inhibit specific Zn2+-dependent DUB activity and inflammation

抑制特定 Zn2+ 依赖性 DUB 活性和炎症的分子胶

Francesca Chandler, Poli Adi Narayana Reddy, Smita Bhutda, Rebecca L Ross, Miriam Walden, Kieran Walker, Stefano Di Donato, Joel A Cassel, Michael A Prakesch, Ahmed Aman, Alessandro Datti, Lisa J Campbell, Martina Foglizzo, Lillie Bell, Daniel N Stein, James R Ault, Rima S Al-Awar, Antonio N Calabre

Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor

OICR12694 的发现:一种新型、高效、选择性强且口服生物利用度高的 BCL6 BTB 抑制剂

Mamai, Ahmed; Chau, Anh M; Wilson, Brian J; Watson, Iain D; Joseph, Babu B; Subramanian, Pandiaraju R; Morshed, Monzur M; Morin, Justin A; Prakesch, Michael A; Lu, Tianbao; Connolly, Pete; Kuntz, Douglas A; Pomroy, Neil C; Poda, Gennady; Nguyen, Kong; Marcellus, Richard; Strathdee, Graig; Theriault, Brigitte; Subramaniam, Ratheesh; Mohammed, Mohammed; Abibi, Ayome; Chan, Manuel; Winston, Jeffrey; Kiyota, Taira; Undzys, Elijus; Aman, Ahmed; Austin, Nigel; Du Jardin, Marc; Packman, Kathryn; Phillippar, Ulrike; Attar, Riccardo; Edwards, James; O'Meara, Jeff; Uehling, David E; Al-Awar, Rima; Privé, Gilbert G; Isaac, Methvin B

The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia

PKN1-TRAF1信号轴作为慢性淋巴细胞白血病的潜在新靶点

Maria I Edilova, Jaclyn C Law, Safoura Zangiabadi, Kenneth Ting, Achire N Mbanwi, Andrea Arruda, David Uehling, Methvin Isaac, Michael Prakesch, Rima Al-Awar, Mark D Minden, Ali A Abdul-Sater, Tania H Watts

Functional characterization of a PROTAC directed against BRAF mutant V600E

针对 BRAF 突变体 V600E 的 PROTAC 的功能表征

Ganna Posternak #, Xiaojing Tang #, Pierre Maisonneuve #, Ting Jin #, Hugo Lavoie #, Salima Daou, Stephen Orlicky, Theo Goullet de Rugy, Lauren Caldwell, Kin Chan, Ahmed Aman, Michael Prakesch, Gennady Poda, Pavel Mader, Cassandra Wong, Stefan Maier, Julia Kitaygorodsky, Brett Larsen, Karen Colwill,

Sorafenib as an Inhibitor of RUVBL2

索拉非尼作为RUVBL2抑制剂

Nano, Nardin; Ugwu, Francisca; Seraphim, Thiago V; Li, Tangzhi; Azer, Gina; Isaac, Methvin; Prakesch, Michael; Barbosa, Leandro R S; Ramos, Carlos H I; Datti, Alessandro; Houry, Walid A

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma

PI3K/AKT/mTOR 抑制剂联合阿霉素是治疗平滑肌肉瘤的有效方法

Yael Babichev, Leah Kabaroff, Alessandro Datti, David Uehling, Methvin Isaac, Rima Al-Awar, Michael Prakesch, Ren X Sun, Paul C Boutros, Rosemarie Venier, Brendan C Dickson, Rebecca A Gladdy1

Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors

羟基芳基醛类 IRE1 内切核糖核酸酶抑制剂的结构和作用机制

Mario Sanches, Nicole M Duffy, Manisha Talukdar, Nero Thevakumaran, David Chiovitti, Marella D Canny, Kenneth Lee, Igor Kurinov, David Uehling, Rima Al-awar, Gennadiy Poda, Michael Prakesch, Brian Wilson, Victor Tam, Colleen Schweitzer, Andras Toro, Julie L Lucas, Danka Vuga, Lynn Lehmann, Daniel Du

Use of kinase inhibitors to correct ΔF508-CFTR function

使用激酶抑制剂纠正 ΔF508-CFTR 功能

Agata M Trzcinska-Daneluti, Leo Nguyen, Chong Jiang, Christopher Fladd, David Uehling, Michael Prakesch, Rima Al-awar, Daniela Rotin