日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Multifunctional, Fluorene-Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease

一种多功能、基于芴的胆碱能和GABA能神经传递调节剂，作为阿尔茨海默病姑息治疗的新型候选药物

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202420510
Panek, Dawid; Pasieka, Anna; Jończyk, Jakub; Gawlińska, Milena; Zaręba, Paula; Siwek, Agata; Wolak, Małgorzata; Mordyl, Barbara; Głuch-Lutwin, Monika; Latacz, Gniewomir; Brazzolotto, Xavier; Chantegreil, Fabien; Nachon, Florian; Zdarova Karasova, Jana; Pejchal, Jaroslav; Mzik, Martin; Sestak, Vit; Prchal, Lukas; Odvarkova, Jitka; Soukup, Ondrej; Korabecny, Jan; Sorf, Ales; Hamsikova, Marie; Zemanova, Lucie; Muckova, Lubica; Vánova, Nela; Dryja, Pola; Sałat, Kinga; Höfner, Georg; Wanner, Klaus; Więckowska, Anna; Malawska, Barbara
阿尔茨海默症
发表日期：2025
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Glutamate utilization fuels rapid production of mitochondrial ROS in dendritic cells and drives systemic inflammation during tularemia.

谷氨酸的利用促进树突状细胞中线粒体活性氧的快速产生，并在兔热病期间引发全身炎症

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.adu6271
Fabrik Ivo, Spidlova Petra, Prchal Lukas, Fabrikova Daniela, Viduka Ina, Marecic Valentina, Filimonenko Vlada, Sleha Radek, Vajrychova Marie, Kupcik Rudolf, Soukup Ondrej, Rousar Tomas, Härtlova Anetta, Santic Marina, Stulik Jiri
细胞生物学
炎症
线粒体
发表日期：2025
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Detoxome Capacity of the Adult Rumen Fluke Calicophoron daubneyi Extends into Its Secreted Extracellular Vesicles

成年瘤胃吸虫（Calicophoron daubneyi）的解毒能力延伸至其分泌的细胞外囊泡中。

期刊:Journal of Proteome Research
影响因子:3.6
doi:10.1021/acs.jproteome.4c00615
Allen, Nathan Rhys; Huson, Kathryn M; Prchal, Lukas; Robinson, Mark W; Brophy, Peter M; Morphew, Russell M
囊泡
细胞生物学
发表日期：2025
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Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases

卤代碘解磷定在有机磷酸酯抑制的胆碱酯酶再活化中的合成与评价

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.4c00464
Knittelova, Karolina; Prchalova, Eliska; Fuchsova, Adela; Andrys, Rudolf; Kohoutova, Zuzana; Rademacherova, Sara; Prchal, Lukas; Musilek, Kamil; Malinak, David
发表日期：2024
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Discovery of a 6-Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities.

发现一种 6-氨基苯并[b]噻吩 1,1-二氧化物衍生物 (K2071)，具有信号转导和转录激活因子 3 抑制、抗有丝分裂和衰老治疗活性

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.4c00190
Oleksak Patrik, Rysanek David, Vancurova Marketa, Vasicova Pavla, Urbancokova Alexandra, Novak Josef, Maurencova Dominika, Kashmel Pavel, Houserova Jana, Mikyskova Romana, Novotny Ondrej, Reinis Milan, Juda Pavel, Hons Miroslav, Kroupova Jirina, Sedlak David, Sulimenko Tetyana, Draber Pavel, Chlubnova Marketa, Nepovimova Eugenie, Kuca Kamil, Lisa Miroslav, Andrys Rudolf, Kobrlova Tereza, Soukup Ondrej, Janousek Jiri, Prchal Lukas, Bartek Jiri, Musilek Kamil, Hodny Zdenek
信号转导
细胞衰老
发表日期：2024
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The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs

葡聚糖硫酸钠诱导的胃肠道损伤对实验猪多奈哌齐及其活性代谢物6-O-去甲基多奈哌齐的药代动力学参数和胃肌电活动的影响

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules26082160
Bures, Jan; Tacheci, Ilja; Kvetina, Jaroslav; Radochova, Vera; Prchal, Lukas; Kohoutova, Darina; Valis, Martin; Novak, Martin; Dolezal, Rafael; Kopacova, Marcela; Rejchrt, Stanislav; Sestak, Vit; Knoblochova, Veronika; Peterova, Eva; Zdarova Karasova, Jana
代谢
发表日期：2021
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Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties

发现治疗阿尔茨海默病的可持续药物：具有抗氧化和抗淀粉样蛋白特性的腰果酚衍生的胆碱酯酶抑制剂

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d1md00046b
de Andrade Ramos, Giselle; Souza de Oliveira, Andressa; Bartolini, Manuela; Naldi, Marina; Liparulo, Irene; Bergamini, Christian; Uliassi, Elisa; Wu, Ling; Fraser, Paul E; Abreu, Monica; Kiametis, Alessandra Sofia; Gargano, Ricardo; Silveira, Edilberto Rocha; Brand, Guilherme D; Prchal, Lukas; Soukup, Ondřej; Korábečný, Jan; Bolognesi, Maria Laura; Soares Romeiro, Luiz Antonio
阿尔茨海默症
发表日期：2021
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Substituted Piperazines as Novel Potential Radioprotective Agents

取代哌嗪类化合物作为新型潜在放射防护剂

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules25030532
Filipova, Alzbeta; Marek, Jan; Havelek, Radim; Pejchal, Jaroslav; Jelicova, Marcela; Cizkova, Jana; Majorosova, Martina; Muckova, Lubica; Kucera, Tomas; Prchal, Lukas; Psotka, Miroslav; Zivna, Natalie; Koutova, Darja; Sinkorova, Zuzana; Rezacova, Martina; Tichy, Ales
发表日期：2020
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