Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia
小分子IODVA1对RacGEF VAV3的抑制作用可阻碍RAC信号传导,并克服急性淋巴细胞白血病中对酪氨酸激酶抑制剂的耐药性。
期刊:Leukemia
影响因子:13.4
doi:10.1038/s41375-021-01455-3
Hegde, Shailaja; Gasilina, Anjelika; Wunderlich, Mark; Lin, Yuan; Buchholzer, Marcel; Krumbach, Oliver H F; Akbarzadeh, Mohammad; Ahmadian, Mohammad Reza; Seibel, William; Zheng, Yi; Perentesis, John P; Mizukawa, Benjamin E; Vinnedge, Lisa Privette; Cancelas, José A; Nassar, Nicolas N