日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes

使用嵌合人类 E2 泛素结合酶进行靶向蛋白质降解

Jonathan D Taylor, Nathalie Barrett, Sergio Martinez Cuesta, Katelyn Cassidy, Fiona Pachl, James Dodgson, Radhika Patel, Tuula M Eriksson, Aidan Riley, Matthew Burrell, Christin Bauer, D Gareth Rees, Raffaello Cimbro, Andrew X Zhang, Ralph R Minter, James Hunt, Sandrine Legg

In vitro evolution of antibody affinity via insertional scanning mutagenesis of an entire antibody variable region

通过插入扫描诱变整个抗体可变区来体外进化抗体亲和力

Kalliopi Skamaki, Stephane Emond, Matthieu Chodorge, John Andrews, D Gareth Rees, Daniel Cannon, Bojana Popovic, Andrew Buchanan, Ralph R Minter, Florian Hollfelder

Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13Rα1 and IL-13Rα2

结构表征揭示 IL-13 中和单克隆抗体 Tralokinumab 抑制与 IL-13Rα1 和 IL-13Rα2 结合的机制

B Popovic, J Breed, D G Rees, M J Gardener, L M K Vinall, B Kemp, J Spooner, J Keen, R Minter, F Uddin, G Colice, T Wilkinson, T Vaughan, R D May

Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease

抗生素诱导的出生后发育过程中微生物多样性紊乱会改变老年APPSWE/PS1ΔE9阿尔茨海默病小鼠模型中的淀粉样蛋白病理。

Myles R Minter ,Reinhard Hinterleitner ,Marlies Meisel ,Can Zhang ,Vanessa Leone ,Xiaoqiong Zhang ,Paul Oyler-Castrillo ,Xulun Zhang ,Mark W Musch ,Xunuo Shen ,Bana Jabri ,Eugene B Chang ,Rudolph E Tanzi ,Sangram S Sisodia

Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype

APPSWE/PS1ΔE9 小鼠中 1 型干扰素受体的缺失可保留认知功能并改变神经胶质细胞表型

Myles R Minter, Zachery Moore, Moses Zhang, Kate M Brody, Nigel C Jones, Sandy R Shultz, Juliet M Taylor, Peter J Crack

A Shorter Route to Antibody Binders via Quantitative in vitro Bead-Display Screening and Consensus Analysis

通过定量体外微珠展示筛选和一致性分析实现抗体结合剂的更短途径

Sylwia A Mankowska, Pietro Gatti-Lafranconi, Matthieu Chodorge, Sudharsan Sridharan, Ralph R Minter, Florian Hollfelder

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease

抗生素引起的肠道微生物多样性紊乱影响阿尔茨海默病小鼠模型中的神经炎症和淀粉样变性

Myles R Minter, Can Zhang, Vanessa Leone, Daina L Ringus, Xiaoqiong Zhang, Paul Oyler-Castrillo, Mark W Musch, Fan Liao, Joseph F Ward, David M Holtzman, Eugene B Chang, Rudolph E Tanzi, Sangram S Sisodia

Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease

型干扰素信号介导阿尔茨海默病模型中的神经炎症事件

Juliet M Taylor, Myles R Minter, Andrew G Newman, Moses Zhang, Paul A Adlard, Peter J Crack

Protein engineering and preclinical development of a GM-CSF receptor antibody for the treatment of rheumatoid arthritis

用于治疗类风湿性关节炎的 GM-CSF 受体抗体的蛋白质工程和临床前开发

R R Minter, E S Cohen, B Wang, M Liang, I Vainshtein, G Rees, L Eghobamien, P Harrison, D A Sims, C Matthews, T Wilkinson, P Monk, C Drinkwater, L Fabri, A Nash, M McCourt, L Jermutus, L Roskos, I K Anderson, M A Sleeman

A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency

一系列 Fas 受体激动剂抗体,其亲和力与效力呈负相关

M Chodorge, S Züger, C Stirnimann, C Briand, L Jermutus, M G Grütter, R R Minter