日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers

自分泌干扰素中毒介导 BRCA1/2 突变癌症中 ADAR1 依赖性合成致死

Roman M Chabanon ,Liudmila Shcherbakova ,Magali Lacroix-Triki ,Marine Aglave ,Jean Zeghondy ,Victor Kriaa ,Antoine Gougé ,Marlène Garrido ,Elodie Edmond ,Ludovic Bigot ,Dragomir B Krastev ,Rachel Brough ,Stephen J Pettitt ,Thibault Thomas-Bonafos ,Robert Samstein ,Christophe Massard ,Marc Deloger ,Andrew Nj Tutt ,Fabrice Barlesi ,Yohann Loriot ,Suzette Delaloge ,Marcel Tawk ,Cindy Degerny ,Yea-Lih Lin ,Barbara Pistilli ,Philippe Pasero ,Christopher J Lord ,Sophie Postel-Vinay

PPP2R1A mutations cause ATR inhibitor sensitivity in ovarian clear cell carcinoma

PPP2R1A 突变导致卵巢透明细胞癌对 ATR 抑制剂产生敏感性

James Stewart, Dragomir B Krastev #, Rachel Brough #, Diana Zatreanu, Feifei Song, Joseph S Baxter, Sandhya Sridhar, Jessica Frankum, Asha Konde, William Yang, Syed Haider, John Alexander, Kai Betteridge, Aditi Gulati, Ayoma D Attygalle, Katherine Vroobel, Rachael Natrajan, Saira Khalique, Theodoros

CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13

CDK12 缺失驱动前列腺癌进展、转录-复制冲突以及与旁系同源基因 CDK13 的合成致死性

Jean Ching-Yi Tien ,Jie Luo ,Yu Chang ,Yuping Zhang ,Yunhui Cheng ,Xiaoju Wang ,Jianzhang Yang ,Rahul Mannan ,Somnath Mahapatra ,Palak Shah ,Xiao-Ming Wang ,Abigail J Todd ,Sanjana Eyunni ,Caleb Cheng ,Ryan J Rebernick ,Lanbo Xiao ,Yi Bao ,James Neiswender ,Rachel Brough ,Stephen J Pettitt ,Xuhong Cao ,Stephanie J Miner ,Licheng Zhou ,Yi-Mi Wu ,Estefania Labanca ,Yuzhuo Wang ,Abhijit Parolia ,Marcin Cieslik ,Dan R Robinson ,Zhen Wang ,Felix Y Feng ,Jonathan Chou ,Christopher J Lord ,Ke Ding ,Arul M Chinnaiyan

Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

癌症相关的FBXW7缺失与靶向CDC7的药物治疗具有合成致死性。

Joseph S Baxter ,Rachel Brough ,Dragomir B Krastev ,Feifei Song ,Sandhya Sridhar ,Aditi Gulati ,John Alexander ,Theodoros I Roumeliotis ,Zuza Kozik ,Jyoti S Choudhary ,Syed Haider ,Stephen J Pettitt ,Andrew N J Tutt ,Christopher J Lord

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

CDK12 缺失会促进前列腺癌的发展,同时暴露出基于旁系同源物的合成致死性的弱点

Jean Ching-Yi Tien, Yu Chang, Yuping Zhang, Jonathan Chou, Yunhui Cheng, Xiaoju Wang, Jianzhang Yang, Rahul Mannan, Palak Shah, Xiao-Ming Wang, Abigail J Todd, Sanjana Eyunni, Caleb Cheng, Ryan J Rebernick, Lanbo Xiao, Yi Bao, James Neiswender, Rachel Brough, Stephen J Pettitt, Xuhong Cao, Stephanie

MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

MND1 和 PSMC3IP 控制有丝分裂细胞中的 PARP 抑制剂敏感性

Anabel Zelceski, Paola Francica, Lea Lingg, Merve Mutlu, Colin Stok, Martin Liptay, John Alexander, Joseph S Baxter, Rachel Brough, Aditi Gulati, Syed Haider, Maya Raghunandan, Feifei Song, Sandhya Sridhar, Josep V Forment, Mark J O'Connor, Barry R Davies, Marcel A T M van Vugt, Dragomir B Krastev, 

A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant

HUWE1 缺陷通过调节 BRCA1-∆11q 剪接变体导致 PARP 抑制剂耐药性

Stephen J Pettitt #, Nan Shao #, Diana Zatreanu, Jessica Frankum, Ilirjana Bajrami, Rachel Brough, Dragomir B Krastev, Theodoros I Roumeliotis, Jyoti S Choudhary, Sonja Lorenz, Alistair Rust, Johann S de Bono, Timothy A Yap, Andrew N J Tutt, Christopher J Lord

SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance

SMG8/SMG9 异二聚体丢失调节 SMG1 激酶以驱动 ATR 抑制剂耐药性

Marta J Llorca-Cardenosa, Lauren I Aronson, Dragomir B Krastev, Jadwiga Nieminuszczy, John Alexander, Feifei Song, Malgorzata Dylewska, Ronan Broderick, Rachel Brough, Astrid Zimmermann, Frank T Zenke, Bora Gurel, Ruth Riisnaes, Ana Ferreira, Theodoros Roumeliotis, Jyoti Choudhary, Stephen J Pettitt

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

ALC1 核小体重塑缺陷导致 PARPi 敏感化,并与 HRD 产生合成致死性。

Graeme Hewitt ,Valerie Borel ,Sandra Segura-Bayona ,Tohru Takaki ,Phil Ruis ,Roberto Bellelli ,Laura C Lehmann ,Lucia Sommerova ,Aleksandra Vancevska ,Antonia Tomas-Loba ,Kang Zhu ,Christopher Cooper ,Kasper Fugger ,Harshil Patel ,Robert Goldstone ,Deborah Schneider-Luftman ,Ellie Herbert ,Gordon Stamp ,Rachel Brough ,Stephen Pettitt ,Christopher J Lord ,Stephen C West ,Ivan Ahel ,Dragana Ahel ,J Ross Chapman ,Sebastian Deindl ,Simon J Boulton

Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency

Sirtuin 抑制与 BRCA1 或 BRCA2 缺陷共同致死

Ilirjana Bajrami #, Callum Walker #, Dragomir B Krastev, Daniel Weekes, Feifei Song, Andrew J Wicks, John Alexander, Syed Haider, Rachel Brough, Stephen J Pettitt, Andrew N J Tutt, Christopher J Lord