日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Personalized Medicine in Cystic Fibrosis: Characterization of Eight Rare CFTR Variants in Intestinal Organoids and Cellular Models

囊性纤维化个性化医疗：肠道类器官和细胞模型中八种罕见CFTR变异体的表征

期刊:Molecular Diagnosis & Therapy
影响因子:4.4
doi:10.1007/s40291-025-00806-5
Railean, Violeta; Rodrigues, Cláudia S; Pankonien, Ines; Ramalho, Sofia S; Silva, Iris A L; Doušová, Tereza; Castanhinha, Susana; Azevedo, Pilar; Roda, Juliana; Farinha, Carlos M; Amaral, Margarida D
3D/类器官
CFTR
细胞生物学
发表日期：2026
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CFTR ion transport deficiency primes the epithelium for partial epithelial-mesenchymal transition in cystic fibrosis.

囊性纤维化中 CFTR 离子转运缺陷使上皮细胞更容易发生部分上皮-间质转化

期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2025.1655479
Rodrigues Cláudia S, Canto Matilde, Torres Raquel, Railean Violeta, Ramalho Sofia S, Farinha Carlos M, Pankonien Ines, Amaral Margarida D
细胞生物学
发表日期：2025
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Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators.

全球功能基因组学揭示 GRK5 是囊性纤维化治疗靶点，可与现有调节剂产生协同作用

期刊:iScience
影响因子:4.1
doi:10.1016/j.isci.2025.111942
Botelho Hugo M, Lopes-Pacheco Miquéias, Pinto Madalena C, Railean Violeta, Pankonien Ines, Caleiro Mariana F, Clarke Luka A, Cachatra Vasco, Neumann Beate, Tischer Christian, Moiteiro Cristina, Ousingsawat Jiraporn, Kunzelmann Karl, Pepperkok Rainer, Amaral Margarida D
其它
发表日期：2025
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Synthesis and the In Vitro Evaluation of Antitumor Activity of Novel Thiobenzanilides

新型硫代苯甲酰化合物的合成及其体外抗肿瘤活性评价

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules28041877
Álvaro-Martins, Maria João; Railean, Violeta; Martins, Filomena; Machuqueiro, Miguel; Pacheco, Rita; Santos, Susana
肿瘤
肿瘤免疫
发表日期：2023
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Personalized medicine: Function of CFTR variant p.Arg334Trp is rescued by currently available CFTR modulators

个性化医疗：目前可用的CFTR调节剂可以恢复CFTR变异体p.Arg334Trp的功能

期刊:Frontiers in Molecular Biosciences
影响因子:4
doi:10.3389/fmolb.2023.1155705
Railean, Violeta; Rodrigues, Cláudia S; Ramalho, Sofia S; Silva, Iris A L; Bartosch, Jan; Farinha, Carlos M; Pankonien, Ines; Amaral, Margarida D
CFTR
发表日期：2023
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Personalized Medicine Based on Nasal Epithelial Cells: Comparative Studies with Rectal Biopsies and Intestinal Organoids

基于鼻上皮细胞的个性化医疗：与直肠活检和肠道类器官的比较研究

期刊:Journal of Personalized Medicine
影响因子:3
doi:10.3390/jpm11050421
Silva, Iris A L; Railean, Violeta; Duarte, Aires; Amaral, Margarida D
上皮细胞
细胞生物学
3D/类器官
发表日期：2021
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Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A>G.

类器官作为囊性纤维化中超罕见突变的个性化医疗工具：S955P 和 1717-2A>G 的案例

期刊:Biochimica et Biophysica Acta-Molecular Basis of Disease
影响因子:4.2
doi:10.1016/j.bbadis.2020.165905
Silva Iris A L, Doušová Tereza, Ramalho Sofia, Centeio Raquel, Clarke Luka A, Railean Violeta, Botelho Hugo M, Holubová Andrea, Valášková Iveta, Yeh Jiunn-Tyng, Hwang Tzyh-Chang, Farinha Carlos M, Kunzelmann Karl, Amaral Margarida D
3D/类器官
发表日期：2020
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