日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Increased CFTR expression and function from an optimized lentiviral vector for cystic fibrosis gene therapy

优化慢病毒载体增强 CFTR 表达和功能,用于囊性纤维化基因治疗

Laura I Marquez Loza, Ashley L Cooney, Qian Dong, Christoph O Randak, Stefano Rivella, Patrick L Sinn, Paul B McCray Jr

An elusive adenylate cyclase complicit in cholera is exposed

一种与霍乱有关的难以捉摸的腺苷酸环化酶被揭露

Randak, Christoph O

Monocyte derived macrophages from CF pigs exhibit increased inflammatory responses at birth

CF 猪的单核细胞衍生巨噬细胞在出生时表现出增强的炎症反应

Lily Paemka, Brian N McCullagh, Mahmoud H Abou Alaiwa, David A Stoltz, Qian Dong, Christoph O Randak, Robert D Gray, Paul B McCray Jr

Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia

突变保守的 Q 环谷氨酰胺 1291 选择性地破坏 ATP 结合盒 (ABC) 腺苷酸激酶囊性纤维化跨膜传导调节器 (CFTR) 的腺苷酸激酶依赖性通道门控,并降低原发性人类气道上皮中的通道功能

Qian Dong, Sarah E Ernst, Lynda S Ostedgaard, Viral S Shah, Amanda R Ver Heul, Michael J Welsh, Christoph O Randak

CFTR-deficient pigs display peripheral nervous system defects at birth

CFTR缺陷型猪出生时即表现出周围神经系统缺陷。

Reznikov, Leah R; Dong, Qian; Chen, Jeng-Haur; Moninger, Thomas O; Park, Jung Min; Zhang, Yuzhou; Du, Jianyang; Hildebrand, Michael S; Smith, Richard J H; Randak, Christoph O; Stoltz, David A; Welsh, Michael J

ATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites

ATP 和 AMP 相互影响它们与 ATP 结合盒 (ABC) 腺苷酸激酶囊性纤维化跨膜传导调节器 (CFTR) 在不同的结合位点的相互作用

Christoph O Randak, Qian Dong, Amanda R Ver Heul, Adrian H Elcock, Michael J Welsh

Hepatic proteome sensitivity in rainbow trout after chronically exposed to a human pharmaceutical verapamil

长期暴露于人类药物维拉帕米后虹鳟的肝脏蛋白质组敏感性

Zhi-Hua Li, Ping Li, Miroslav Sulc, Martin Hulak, Tomas Randak

Demonstration of phosphoryl group transfer indicates that the ATP-binding cassette (ABC) transporter cystic fibrosis transmembrane conductance regulator (CFTR) exhibits adenylate kinase activity

磷酸基团转移的证实表明,ATP结合盒(ABC)转运蛋白囊性纤维化跨膜电导调节因子(CFTR)具有腺苷酸激酶活性。

Randak, Christoph O; Ver Heul, Amanda R; Welsh, Michael J

Biomarkers of Contaminant Exposure in Chub (Leuciscus cephalus L.) - Biomonitoring of Major Rivers in the Czech Republic

捷克共和国主要河流生物监测中,欧洲鲴鱼(Leuciscus cephalus L.)污染物暴露的生物标志物

Havelkova, Marcela; Blahova, Jana; Kroupova, Hana; Randak, Tomas; Slatinska, Iveta; Leontovycova, Drahomira; Grabic, Roman; Pospisil, Richard; Svobodova, Zdenka

A mutation in CFTR modifies the effects of the adenylate kinase inhibitor Ap5A on channel gating

CFTR 突变会改变腺苷酸激酶抑制剂 Ap5A 对通道门控的影响

Qian Dong, Christoph O Randak, Michael J Welsh