日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes

基于理论的强效长效 FGF21 类似物设计,用于治疗 2 型糖尿病

Randy Hecht, Yue-Sheng Li, Jeonghoon Sun, Ed Belouski, Michael Hall, Todd Hager, Junming Yie, Wei Wang, Dwight Winters, Stephen Smith, Chris Spahr, Lei-Ting Tam, Zhongnan Shen, Shanaka Stanislaus, Narumol Chinookoswong, Yvonne Lau, Allen Sickmier, Mark Leo Michaels, Thomas Boone, Murielle M Véniant,

The FGFR D3 domain determines receptor selectivity for fibroblast growth factor 21

FGFR D3 结构域决定成纤维细胞生长因子 21 的受体选择性

Jamila Gupte, Li Yang, Xinle Wu, Jennifer Weiszmann, Randy Hecht, Bryan Lemon, Richard Lindberg, Zhulun Wang, Yang Li

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation

FGF19 诱导的肝细胞增殖是通过 FGFR4 激活介导的

Xinle Wu, Hongfei Ge, Bryan Lemon, Steven Vonderfecht, Jennifer Weiszmann, Randy Hecht, Jamila Gupte, Todd Hager, Zhulun Wang, Richard Lindberg, Yang Li

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

成纤维细胞生长因子 21 可逆转肝脂肪变性、增加能量消耗并改善饮食诱导的肥胖小鼠的胰岛素敏感性

Jing Xu, David J Lloyd, Clarence Hale, Shanaka Stanislaus, Michelle Chen, Glenn Sivits, Steven Vonderfecht, Randy Hecht, Yue-Sheng Li, Richard A Lindberg, Jin-Long Chen, Dae Young Jung, Zhiyou Zhang, Hwi-Jin Ko, Jason K Kim, Murielle M Véniant

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects

FGF21 在胰岛素抵抗小鼠模型中的急性降糖和胰岛素增敏作用——与肝脏和脂肪组织效应相关

Jing Xu, Shanaka Stanislaus, Narumol Chinookoswong, Yvonne Y Lau, Todd Hager, Jennifer Patel, Hongfei Ge, Jen Weiszmann, Shu-Chen Lu, Melissa Graham, Jim Busby, Randy Hecht, Yue-Sheng Li, Yang Li, Richard Lindberg, Murielle M Véniant